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Wound healing activity of an aqueous extract of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes).
Gupta A, Kirar V, Keshri GK, Gola S, Yadav A, Negi PS, Misra K.
Int J Med Mushrooms. 2014;16(4):345-54.

Biological activity of Ganoderma lucidum basidiocarps cultivated on alternative and commercial substrate.
Cilerd?i? J, Vukojevi? J, Staji? M, Stanojkovi? T, Glamo?lija J.
J Ethnopharmacol. 2014 Aug 8;155(1):312-9. doi: 10.1016/j.jep.2014.05.036. Epub 2014 May 29.

Screening and isolation for anti-hepatofibrotic components from medicinal mushrooms using TGF-(β1-induced live fibrosis in hepatic stellate cells.
Geng Y, Wang J, Xie M, Lu Z, Xu H, Shi JS, Xu ZH.
Int J Med Mushrooms. 2014;16(6):529-39.

Anti-inflammatory and hepatoprotective effects of Ganoderma lucidum polysaccharides on carbon tetrachloride-induced hepatocyte damage in common carp (Cyprinus carpio L.).
Liu YJ, Du JL, Cao LP, Jia R, Shen YJ, Zhao CY, Xu P, Yin GJ.
Int J Med Mushrooms. 2014;16(6):529-39.

A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle.
Oliveira M, Reis FS, Sousa D, Tavares C, Lima RT, Ferreira IC, dos Santos T, Vasconcelos MH.
Food Funct. 2014 Jul 25;5(7):1389-94. doi: 10.1039/c4fo00258j.

An Immunomodulatory Protein (Ling Zhi-8) from a Ganoderma lucidum Induced Acceleration of Wound Healing in Rat Liver Tissues after Monopolar Electrosurgery.
Lin HJ, Chang YS, Lin LH, Haung CF, Wu CY, Ou KL.
Evid Based Complement Alternat Med. 2014;2014:916531. doi: 10.1155/2014/916531. Epub 2014 May 5.

Antihepatoma and liver protective potentials of ganoderma lucidum ( ling zhi) fermented in a medium containing black soybean ( hēi dòu) and astragalus membranaceus ( shēng huáng qí).
Min-Chang G, Wei-Hong T, Zhen X, Jie S.
Evid Based Complement Alternat Med. 2014;2014:182817. doi: 10.1155/2014/182817. Epub 2014 Feb 10.

Effects of Selenium-Enriched Protein from Ganoderma lucidum on the Levels of IL-1 β and TNF- α , Oxidative Stress, and NF- κ B Activation in Ovalbumin-Induced Asthmatic Mice.
Min-Chang G, Wei-Hong T, Zhen X, Jie S.
Evid Based Complement Alternat Med. 2014;2014:182817. doi: 10.1155/2014/182817. Epub 2014 Feb 10.

Hepatoprotective effects of triterpenoids from Ganoderma cochlear.
Peng XR, Liu JQ, Wang CF, Li XY, Shu Y, Zhou L, Qiu MH.
J Nat Prod. 2014 Apr 25;77(4):737-43. doi: 10.1021/np400323u. Epub 2014 Feb 21.

Post-treatment of Ganoderma lucidum reduced liver fibrosis induced by thioacetamide in mice.
Wu YW, Fang HL, Lin WC.
Phytother Res. 2010 Apr;24(4):494-9.    

Ganoderma lucidum extracts inhibited leukemia WEHI-3 cells in BALB/c mice and promoted an immune response in vivo.
Chang YH, Yang JS, Yang JL, Wu CL, Chang SJ, Lu KW, Lin JJ, Hsia TC, Lin YT, Ho CC, Wood WG, Chung JG.
Biosci Biotechnol Biochem. 2009 Dec;73(12):2589-94.

Preparation, characterization, and antiproliferative activities of the Se-containing polysaccharide SeGLP-2B-1 from Se-enriched Ganoderma lucidum.
Shang D, Zhang J, Wen L, Li Y, Cui Q.
J Agric Food Chem. 2009 Sep 9;57(17):7737-42.   

Free-radical scavenging and mitochondrial antioxidant activities of Reishi-Ganoderma lucidum (Curt: Fr) P. Karst and Arogyapacha-Trichopus zeylanicus Gaertn extracts.
Cherian E, Sudheesh NP, Janardhanan KK, Patani G.
J Basic Clin Physiol Pharmacol. 2009;20(4):289-307.

Ganoderma lucidum: a potent pharmacological macrofungus.
Sanodiya BS, Thakur GS, Baghel RK, Prasad GB, Bisen PS.
Curr Pharm Biotechnol. 2009 Dec;10(8):717-42.

Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice.
Seto SW, Lam TY, Tam HL, Au AL, Chan SW, Wu JH, Yu PH, Leung GP, Ngai SM, Yeung JH, Leung PS, Lee SM, Kwan YW.
Phytomedicine. 2009 May;16(5):426-36.

Ganoderma lucidum extract attenuates the proliferation of hepatic stellate cells by blocking the PDGF receptor.
Wang GJ, Huang YJ, Chen DH, Lin YL.
Phytother Res. 2009 Jun;23(6):833-9. 

[Effect of Ganoderma lucidum polysaccharides on intestinal mucosal immune system in H22 liver cancer bearing mice]
Zhou GQ, Zhao HY, Lu C.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Apr;29(4):335-9.

Ganoderma lucidum extract attenuates the proliferation of hepatic stellate cells by blocking the PDGF receptor.
Wang GJ, Huang YJ, Chen DH, Lin YL.
Phytother Res. 2009 Jun;23(6):833-9.

Cytotoxic activities of 9,11-dehydroergosterol peroxide and ergosterol peroxide from the fermentation mycelia of ganoderma lucidum cultivated in the medium containing leguminous plants on Hep 3B cells.
Chen YK, Kuo YH, Chiang BH, Lo JM, Sheen LY.
J Agric Food Chem. 2009 Jul 8;57(13):5713-9.  

Inhibitory effects of ganoderma lucidum on tumorigenesis and metastasis of human hepatoma cells in cells and animal models.
Weng CJ, Chau CF, Yen GC, Liao JW, Chen DH, Chen KD.
J Agric Food Chem. 2009 Jun 10;57(11):5049-57.  

Evaluation of antiproliferative activities and action mechanisms of extracts from two species of Ganoderma on tumor cell lines.
Liu YW, Gao JL, Guan J, Qian ZM, Feng K, Li SP.
J Agric Food Chem. 2009 Apr 22;57(8):3087-93.    

[Effects of Ganoderma lucidum spores on HepG2 cells proliferation and growth cycle]
Li L, Li T, Wang XJ, Xu JP, Wang SG.
Zhong Yao Cai. 2008 Oct;31(10):1514-8.

Preventive effect of Ganoderma amboinense on acetaminophen-induced acute liver injury.
Hsu CC, Lin KY, Wang ZH, Lin WL, Yin MC.
Phytomedicine. 2008 Jun 23.

Hepatoprotective effects of Ganoderma lucidum peptides against D-galactosamine-induced liver injury in mice.
Shi Y, Sun J, He H, Guo H, Zhang S.
J Ethnopharmacol. 2008 May 22;117(3):415-9.

Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of NF-kappaB and AP-1.
Weng CJ, Chau CF, Hsieh YS, Yang SF, Yen GC.
Carcinogenesis. 2008 Jan;29(1):147-56.

Effects of Ganoderma lucidum polysaccharide on CYP2E1, CYP1A2 and CYP3A activities in BCG-immune hepatic injury in rats.
Wang X, Zhao X, Li D, Lou YQ, Lin ZB, Zhang GL.
Biol Pharm Bull. 2007 Sep;30(9):1702-6.

Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder.
Wanmuang H, Leopairut J, Kositchaiwat C, Wananukul W, Bunyaratvej S.
J Med Assoc Thai. 2007 Jan;90(1):179-81. 

The anti-invasive effect of lucidenic acids isolated from a new Ganoderma lucidum strain.
Weng CJ, Chau CF, Chen KD, Chen DH, Yen GC.
Mol Nutr Food Res. 2007 Dec;51(12):1472-7.

[Mechanism and protective effect of glossy ganoderma decoction on the activities of RNA polymerase in hepatocyte of rabbits with Amanita mushroom poisoning]
Xiao GL, Yang N, Zhang CH, Hu SY.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007 Aug;32(4):637-40.

[Antitumor activity of extracts of Ganoderma lucidum and their protective effects on damaged HL-7702 cells induced by radiotherapy and chemotherapy]
Wang DH, Weng XC.
Zhongguo Zhong Yao Za Zhi. 2006 Oct;31(19):1618-22.

[The pharmacological study of Ganoderma spores and their active components]
Lin ZB, Wang PY.
Beijing Da Xue Xue Bao. 2006 Oct 18;38(5):541-7.

Structure-activity relationship for inhibition of 5alpha-reductase by triterpenoids isolated from Ganoderma lucidum.
Liu J, Kurashiki K, Shimizu K, Kondo R.
Bioorg Med Chem. 2006 Dec 15;14(24):8654-60.

Anti-hepatitis B activities of ganoderic acid from Ganoderma lucidum.
Li YQ, Wang SF.
Biotechnol Lett. 2006 Jun;28(11):837-41.

Antimutagenic activity of methanolic extract of Ganoderma lucidum and its effect on hepatic damage caused by benzo[a]pyrene.
Lakshmi B, Ajith TA, Jose N, Janardhanan KK.
J Ethnopharmacol. 2006 Sep 19;107(2):297-303.

Ganoderiol F, a ganoderma triterpene, induces senescence in hepatoma HepG2 cells.
Chang UM, Li CH, Lin LI, Huang CP, Kan LS, Lin SB.
Life Sci. 2006 Aug 15;79(12):1129-39.

Anti-hepatitis activities in the broth of Ganoderma lucidum supplemented with a Chinese herbal medicine.
Li Y, Yang Y, Fang L, Zhang Z, Jin J, Zhang K.
Am J Chin Med. 2006;34(2):341-9. 

In vitro and in vivo protective effects of proteoglycan isolated from mycelia of Ganoderma lucidum on carbon tetrachloride-induced liver injury.
Yang XJ, Liu J, Ye LB, Yang F, Ye L, Gao JR, Wu ZH.
World J Gastroenterol. 2006 Mar 7;12(9):1379-85.

Ameliorative effect of Ganoderma lucidum on carbon tetrachloride-induced liver fibrosis in rats.
Lin WC, Lin WL.
World J Gastroenterol. 2006 Jan 14;12(2):265-70.

5alpha-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum.
Liu J, Kurashiki K, Shimizu K, Kondo R.
Biol Pharm Bull. 2006 Feb;29(2):392-5.

Ganoderic acid produced from submerged culture of Ganoderma lucidum induces cell cycle arrest and cytotoxicity in human hepatoma cell line BEL7402.
Yang HL.
Biotechnol Lett. 2005 Jun;27(12):835-8.

Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors.
Hajjaj H, Macé C, Roberts M, Niederberger P, Fay LB.
Appl Environ Microbiol. 2005 Jul;71(7):3653-8.

[In vitro inhibitory efects on HBsAg and HBeAg secretion of 3 new components produced by Ganoderma lucidum in the medium contained Radix sophorae flavescentis extract]
Li YQ, Zhang KC.
Wei Sheng Wu Xue Bao. 2005 Aug;45(4):643-6.

Effect of Ganoderma tsugae on chronically carbon tetrachloride-intoxicated rats.
Wu YW, Chen KD, Lin WC.
Am J Chin Med. 2004;32(6):841-50.

Novel antioxidant peptides from fermented mushroom Ganoderma lucidum.
Sun J, He H, Xie BJ.
J Agric Food Chem. 2004 Oct 20;52(21):6646-52.    

Hepatotoxicity due to a formulation of Ganoderma lucidum (lingzhi).
Yuen MF, Ip P, Ng WK, Lai CL.
J Hepatol. 2004 Oct;41(4):686-7.

Effect of medicinal plant extracts on forced swimming capacity in mice.
Jung K, Kim IH, Han D.
J Ethnopharmacol. 2004 Jul;93(1):75-81.

Ganoderma lucidum ("Lingzhi"), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study.
Wachtel-Galor S, Tomlinson B, Benzie IF.
Br J Nutr. 2004 Feb;91(2):263-9.

Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs.
Berger A, Rein D, Kratky E, Monnard I, Hajjaj H, Meirim I, Piguet-Welsch C, Hauser J, Mace K, Niederberger P.
Lipids Health Dis. 2004 Feb 18;3:2.

Chromatographic and electrophoretic methods for Lingzhi pharmacologically active components.
Huie CW, Di X.
J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Dec 5;812(1-2):241-57.

[Clinical observation on treatment of Russula subnigricans poisoning patients by Ganoderma lucidum decoction]
Xiao GL, Liu FY, Chen ZH.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003 Apr;23(4):278-80.

Triterpene-enriched extracts from Ganoderma lucidum inhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogen-activated protein kinases and G2-phase cell cycle arrest.
Lin SB, Li CH, Lee SS, Kan LS.
Life Sci. 2003 Apr 11;72(21):2381-90.

Antiperoxidative, anti-inflammatory, and antimutagenic activities of ethanol extract of the mycelium of Ganoderma lucidum occurring in South India.
Lakshmi B, Ajith TA, Sheena N, Gunapalan N, Janardhanan KK.
Teratog Carcinog Mutagen. 2003;Suppl 1:85-97.

Antitumor and antimetastatic effects on liver of triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of an active substance.
Kimura Y, Taniguchi M, Baba K.
Anticancer Res. 2002 Nov-Dec;22(6A):3309-18. 

Hepatoprotective role of Ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice.
Zhang GL, Wang YH, Ni W, Teng HL, Lin ZB.
World J Gastroenterol. 2002 Aug;8(4):728-33.

Antitumor activity of the sporoderm-broken germinating spores of Ganoderma lucidum.
Liu X, Yuan JP, Chung CK, Chen XJ.
Cancer Lett. 2002 Aug 28;182(2):155-61. 

Evaluation of the hepatic and renal-protective effects of Ganoderma lucidum in mice.
Shieh YH, Liu CF, Huang YK, Yang JY, Wu IL, Lin CH, Li SC.
Am J Chin Med. 2001;29(3-4):501-7. 

Prevention of autoantibody formation and prolonged survival in New Zealand Black/New Zealand White F1 mice with an ancient Chinese herb, Ganoderma tsugae.
Lai NS, Lin RH, Lai RS, Kun UC, Leu SC.
Lupus. 2001;10(7):461-5.  

New lanostanoids from Ganoderma lucidum that induce NAD(P)H:quinone oxidoreductase in cultured hepalcic7 murine hepatoma cells.
Ha TB, Gerhäuser C, Zhang WD, Ho-Chong-Line N, Fourasté I.
Planta Med. 2000 Oct;66(7):681-4.

In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor).
Kim HS, Kacew S, Lee BM.
Carcinogenesis. 1999 Aug;20(8):1637-40. 

Beta-glucuronidase-inhibitory activity and hepatoprotective effect of Ganoderma lucidum.
Kim DH, Shim SB, Kim NJ, Jang IS.
Biol Pharm Bull. 1999 Feb;22(2):162-4.

Antifibrotic effects of a polysaccharide extracted from Ganoderma lucidum, glycyrrhizin, and pentoxifylline in rats with cirrhosis induced by biliary obstruction.
Park EJ, Ko G, Kim J, Sohn DH.
Biol Pharm Bull. 1997 Apr;20(4):417-20. Erratum in: Biol Pharm Bull 1998 Jun;21(6):649.

Radical scavenger and antihepatotoxic activity of Ganoderma formosanum, Ganoderma lucidum and Ganoderma neo-japonicum.
Lin JM, Lin CC, Chen MF, Ujiie T, Takada A.
J Ethnopharmacol. 1995 Jun 23;47(1):33-41. 

[Testing of plant extracts preparations for prevention and non-toxic therapy of oncologic diseases in experimental models]
Bocharova OA, Serebriakova RV.
Vestn Ross Akad Med Nauk. 1994;(2):52-5.

Evaluation of the anti-inflammatory and liver-protective effects of anoectochilus formosanus, ganoderma lucidum and gynostemma pentaphyllum in rats.
Lin JM, Lin CC, Chiu HF, Yang JJ, Lee SG.
Am J Chin Med. 1993;21(1):59-69.

Medicinal benefits of the mushroom Ganoderma.
Jong SC, Birmingham JM.
Adv Appl Microbiol. 1992;37:101-34. Review.

Immunomodulator, LZ-8, prevents antibody production in mice.
Kino K, Sone T, Watanabe J, Yamashita A, Tsuboi H, Miyajima H, Tsunoo H.
Int J Immunopharmacol. 1991;13(8):1109-15.    : 1814848 [PubMed - indexed for MEDLINE]Related citations

Mechanisms of hypoglycemic activity of ganoderan B: a glycan of Ganoderma lucidum fruit bodies.
Hikino H, Ishiyama M, Suzuki Y, Konno C.
Planta Med. 1989 Oct;55(5):423-8.

Ganoderic acid and its derivatives as cholesterol synthesis inhibitors.
Komoda Y, Shimizu M, Sonoda Y, Sato Y.
Chem Pharm Bull (Tokyo). 1989 Feb;37(2):531-3. 

[Therapeutic effect of Ganoderma applonatum (GA) on chronic hepatitis B]
Lin XY, Huang KL, Zhu RP.
Zhonghua Nei Ke Za Zhi. 1988 Oct;27(10):618-20, 652-3.

[Effect of six edible plants on the development of AFB1-induced gamma-glutamyltranspeptidase-positive hepatocyte foci in rats]
Chen ZY, Yan RQ, Qin GZ, Qin LL.
Zhonghua Zhong Liu Za Zhi. 1987 Mar;9(2):109-11.

Some pharmacological actions of the spores of Ganoderma lucidum and the mycelium of Guanoderma capense (Lloyd) Teng cultivated by submerged fermentation.
Gengtao L, Tiantong B, Xinyi N, Shuzhen L, Zhenyu S.
Chin Med J (Engl). 1979 Jul;92(7):496-500.

[A comparison of the protective actions of biphenyl dimethyl-dicarboxylate, trans-stilbene, alcoholic extracts of Fructus schizandrae and Ganoderma against experimental liver injury in mice (author's transl)]
Liu GT, Wang GF, Wei HL, Bao TT, Song ZY.
Yao Xue Xue Bao. 1979;14(10):598-604.

[Some pharmacological actions of Ganoderma lucidum and G. japonicum (FR) Llyod on mouse liver (author's transl)]
Liu GT, Bao TT, Wei HL, Song ZY.
Yao Xue Xue Bao. 1979;14(5):284-7.

Effects of Ganoderma lucidum on obstructive jaundice-induced oxidative stress.
Aydin S, Aytac E, Uzun H, Altug T, Mansur B, Saygili S, Buyukpinarbasili N, Sariyar M.
Asian J Surg. 2010 Oct;33(4):173-80.

[Preparation of Ganoderma lucidum polysaccharides and triterpenes microemulsion and its anticancer effect in mice with transplant Heps tumors].
Chen Y, Lu H, Song S, Jia X.
Zhongguo Zhong Yao Za Zhi. 2010 Oct;35(20):2679-83. Chinese.

Anti-invasive effect of a rare mushroom, Ganoderma colossum , on human hepatoma cells.
Weng CJ, Fang PS, Chen DH, Chen KD, Yen GC.
J Agric Food Chem. 2010 Jul 14;58(13):7657-63.