Reference Literature
Cancer and Immunity
Cancer and Immunity
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| Using a Natural Triterpenoid to Unlock the Antitumor Effects of Autophagy in B-Cell Lymphoma. |
| Doonan BP, Radwan FFY, Banik NL, Haque A. |
| Biomedicines. 2025 Feb 12;13(2):445. doi: 10.3390/biomedicines13020445. |
| Early Preclinical Studies of Ergosterol Peroxide and Biological Evaluation of Its Derivatives. |
| Ling T, Arroyo-Cruz LV, Smither WR, Seighman EK, Martínez-Montemayor MM, Rivas F. |
| ACS Omega. 2024 Aug 19;9(35):37117-37127. doi: 10.1021/acsomega.4c04350. eCollection 2024 Sep 3. |
| Biosynthesis of gold nanoparticles by fungi and its potential in SERS. |
| Olvera-Aripez J, Camacho-López S, Flores-Castañeda M, Belman-Rodríguez C, Vilchis-Nestor AR, Castro-Longoria E. |
| Bioprocess Biosyst Eng. 2024 Sep;47(9):1585-1593. doi: 10.1007/s00449-024-03053-w. Epub 2024 Jun 26. |
| Spore Oil enhances the effect of cyclophosphamide inhibiting programmed death-1 and prolongs the survival of H22 tumor-bearing mice. |
| Zhaojian J, Hongfei C, Cheng Y, Lin C, Wendong XU, Yaming H, Qin Z, Jing LI, Qin W, Juyan L. |
| J Tradit Chin Med. 2024 Aug;44(4):652-659. doi: 10.19852/j.cnki.jtcm.2024.04.003. |
| Assessment of redox homeostasis via genotoxicity, cytotoxicity, apoptosis and NRF-2 in colorectal cancer cell lines after treatment with Ganoderma lucidum extract. |
| Tülüce Y, Keleş AY, Köstekci S. |
| Drug Chem Toxicol. 2024 Sep;47(5):693-709. doi: 10.1080/01480545.2023.2257403. Epub 2023 Sep 13. |
| Ganoderma lucidum Polysaccharide Supplementation Significantly Activates T-Cell-Mediated Antitumor Immunity and Enhances Anti-PD-1 Immunotherapy Efficacy in Colorectal Cancer. |
| Li W, Zhou Q, Lv B, Li N, Bian X, Chen L, Kong M, Shen Y, Zheng W, Zhang J, Luo F, Luo Z, Liu J, Wu JL. |
| J Agric Food Chem. 2024 May 29;72(21):12072-12082. doi: 10.1021/acs.jafc.3c08385. Epub 2024 May 15. |
| The Efficacy of Ganoderma lucidum Extracts on Treating Endometrial Cancer: A Network Pharmacology Approach. |
| Shi M. |
| Reprod Sci. 2024 Jul;31(7):1881-1894. doi: 10.1007/s43032-024-01500-3. Epub 2024 Mar 6. |
| Ganoderma lucidum spores-derived particulate beta-glucan treatment improves antitumor response by regulating myeloid-derived suppressor cells in triple-negative breast cancer. |
| Bu Y, Liu Q, Shang Y, Zhao Z, Sun H, Chen F, Ma Q, Song J, Cui L, Sun E, Luo Y, Shu L, Jing H, Tan X. |
| Int J Biol Macromol. 2024 Jun;270(Pt 1):131949. doi: 10.1016/j.ijbiomac.2024.131949. Epub 2024 May 15. |
| Ganoderma lucidum extract reverses multidrug resistance in breast cancer cells through inhibiting ATPase activity of the P-glycoprotein via MAPK/ERK signaling pathway. |
| Jiao C, Qiu J, Gong C, Li X, Liang H, He C, Cen S, Xie Y. |
| Exp Cell Res. 2025 Jan 15;444(2):114355. doi: 10.1016/j.yexcr.2024.114355. Epub 2024 Nov 28. |
| Triterpenes from Ganoderma lucidum inhibit hepatocellular carcinoma by regulating enhancer-associated lncRNA in vivo. |
| Zhao R, Zhang C, Tang C, Wu X, Hu S, Luo Q, Jia N, Fan L, Wang Y, Jiang W, Chen Q. |
| J Ethnopharmacol. 2025 Jan 10;336:118706. doi: 10.1016/j.jep.2024.118706. Epub 2024 Aug 24. |
| Correction: Exploring the anti-cancer potential of Ganoderma Lucidum polysaccharides (GLPs) and their versatile role in enhancing drug delivery systems: a multifaceted approach to combat cancer. |
| Gao X, Homayoonfal M. |
| Cancer Cell Int. 2024 May 22;24(1):178. doi: 10.1186/s12935-024-03284-7. |
| Structural clarification of mannoglucan GSBP-2 from Ganoderma sinense and its effects on triple-negative breast cancer migration and invasion. |
| Xie Y, Su Y, Wang Y, Zhang D, Yu Q, Yan C. |
| Int J Biol Macromol. 2024 Jun;269(Pt 1):131903. doi: 10.1016/j.ijbiomac.2024.131903. Epub 2024 Apr 28. |
| Medicinal Mushrooms (PDQ®): Health Professional Version. |
| PDQ Integrative, Alternative, and Complementary Therapies Editorial Board. |
| 2024 Nov 6. In: PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002–. |
| Structural characteization and anti-colorectal cancer activity of a fucogalactan purified from Ganoderma tsugae. |
| Zhang X, Liu S, Wu K, Shu L, Li Y, Li L, Wang D. |
| Carbohydr Polym. 2025 Mar 15;352:123203. doi: 10.1016/j.carbpol.2024.123203. Epub 2024 Dec 30. |
| Selective Antineoplastic Potential of Fractionated Caribbean Native Ganoderma Species Extracts on Triple-Negative Breast Cancer Cells. |
| Arroyo-Cruz LV, Sagardía-González S, Miller K, Ling T, Rivas F, Martínez-Montemayor MM. |
| Pharmaceuticals (Basel). 2024 Jul 1;17(7):864. doi: 10.3390/ph17070864. |
| Network Pharmacology and Bioinformatics Study of Six Medicinal Food Homologous Plants Against Colorectal Cancer. |
| Zhao X, Xiu J, Yang H, Han W, Jin Y. |
| Int J Mol Sci. 2025 Jan 23;26(3):930. doi: 10.3390/ijms26030930. |
| Medicinal Mushrooms in Metastatic Breast Cancer: What Is Their Therapeutic Potential as Adjuvant in Clinical Settings? |
| De Luca F, Roda E, Rossi P, Bottone MG. |
| Curr Issues Mol Biol. 2024 Jul 17;46(7):7577-7591. doi: 10.3390/cimb46070450. |
| Ganoderic acid D attenuates gemcitabine resistance of triple-negative breast cancer cells by inhibiting glycolysis via HIF-1alpha destabilization. |
| Luo B, Song L, Chen L, Cai Y, Zhang M, Wang S. |
| Phytomedicine. 2024 Jul;129:155675. doi: 10.1016/j.phymed.2024.155675. Epub 2024 Apr 23. |
| Medicinal Mushrooms (PDQ®): Patient Version. |
| PDQ Integrative, Alternative, and Complementary Therapies Editorial Board. |
| 2024 Jul 11. In: PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002–. |
| A Review of Ganoderma lucidum Polysaccharide: Preparations, Structures, Physicochemical Properties and Application. |
| Zhong Y, Tan P, Lin H, Zhang D, Chen X, Pang J, Mu R. |
| Foods. 2024 Aug 24;13(17):2665. doi: 10.3390/foods13172665. |
| Targeting CD8+ T cells with natural products for tumor therapy: Revealing insights into the mechanisms. |
| Wang Y, Zeng Y, Yang W, Wang X, Jiang J. |
| Phytomedicine. 2024 Jul;129:155608. doi: 10.1016/j.phymed.2024.155608. Epub 2024 Apr 8. |
| Protective effect of Ganoderma lucidum-fermented crop extracts against hydrogen peroxide- or beta-amyloid-induced damage in human neuronal SH-SY5Y cells. |
| Huang CH, Liao YT, Chen CL, Tsai GJ. |
| BMC Complement Med Ther. 2024 Apr 5;24(1):148. doi: 10.1186/s12906-024-04409-1. |
| Igniting tumour microenvironment in triple-negative breast cancer using a mannose/hyaluronic acid dual-coated Ganoderma polysaccharide-superparamagnetic iron oxide nanocomplex for combinational therapies. |
| Yuan S, Zhu L, Luo Y, Chen X, Jing H, Wang J, Su X, Liang M, Zhuang Z. |
| J Drug Target. 2025 Jan;33(1):111-126. doi: 10.1080/1061186X.2024.2408721. Epub 2024 Oct 30. |
| Integrin alphaV Inhibition by GMI, a Ganoderma Microsporum Immunomodulatory Protein, Abolish Stemness and Migration in EGFR-Mutated Lung Cancer Cells Resistant to Osimertinib. |
| Kang YT, Chang HY, Hsieh YC, Chou CH, Hsin IL, Ko JL. |
| Environ Toxicol. 2024 Dec;39(12):5238-5249. doi: 10.1002/tox.24399. Epub 2024 Aug 17. |
| Potential of natural products and gut microbiome in tumor immunotherapy. |
| Cao L, Wang X, Ma X, Xu M, Li J. |
| Chin Med. 2024 Nov 20;19(1):161. doi: 10.1186/s13020-024-01032-7. |
| Mushrooms and Colorectal Cancer: Unveiling Mechanistic Insights and Therapeutic Innovations. |
| Kurl S, Kaur S, Mittal N, Kaur G. |
| Phytother Res. 2025 Jan;39(1):480-493. doi: 10.1002/ptr.8382. Epub 2024 Nov 11. |
| Targeting TGFbeta receptor-mediated snail and twist: WSG, a polysaccharide from Ganoderma lucidum, and it-based dissolvable microneedle patch suppress melanoma cells. |
| Lo HC, Lin TE, Lin CY, Wang WH, Chen YC, Tsai PH, Su JC, Lu MK, Hsu WH, Lin TY. |
| Carbohydr Polym. 2024 Oct 1;341:122298. doi: 10.1016/j.carbpol.2024.122298. Epub 2024 May 20. |
| Ganoderma lucidum triterpenoids investigating their role in medicinal applications and genomic protection. |
| Raza SHA, Zhong R, Li X, Pant SD, Shen X, BinMowyna MN, Luo L, Lei H. |
| J Pharm Pharmacol. 2024 Dec 2;76(12):1535-1551. doi: 10.1093/jpp/rgae133. |
| Structure Identification of Ganoderma lucidum Spore Polysaccharides and Their Antitumor Activity In Vivo. |
| Liu HM, Cheng J, Wang XY, Jiang Y, Ni J, Zhang Y, Wang W. |
| Molecules. 2024 May 16;29(10):2348. doi: 10.3390/molecules29102348. |
| Research Progress on the Biological Activity of Ganoderic Acids in Ganoderma lucidum over the Last Five Years. |
| Wang S, Wang L, Shangguan J, Jiang A, Ren A. |
| Life (Basel). 2024 Oct 21;14(10):1339. doi: 10.3390/life14101339. |
| Ganoderma lucidum (Curtis) P. Karst. Immunomodulatory Protein Has the Potential to Improve the Prognosis of Breast Cancer Through the Regulation of Key Prognosis-Related Genes. |
| Zuo Z, Wen R, Jing S, Chen X, Liu R, Xue J, Zhang L, Li Q. |
| Pharmaceuticals (Basel). 2024 Dec 16;17(12):1695. doi: 10.3390/ph17121695. |
| Identification of sedative-hypnotic compounds shared by five medicinal Polyporales mushrooms using UPLC-Q-TOF-MS/MS-based untargeted metabolomics. |
| Chen W, Yu JW, Deng YY, Wong LY, Wang C, Liang YL, Leung YT, Tian JY, Wu Y, Leung KS, Hu J, Chen WH, Dou X, Fu XQ, Chen YJ, Yu ZL. |
| Phytomedicine. 2024 Jun;128:155355. doi: 10.1016/j.phymed.2024.155355. Epub 2024 Jan 12. |
| Ganoderic acid T, a Ganoderma triterpenoid, modulates the tumor microenvironment and enhances the chemotherapy and immunotherapy efficacy through downregulating galectin-1 levels. |
| Chen S, Chen K, Lin Y, Wang S, Yu H, Chang C, Cheng T, Hsieh C, Li J, Lai H, Chen D, Huang C. |
| Toxicol Appl Pharmacol. 2024 Oct;491:117069. doi: 10.1016/j.taap.2024.117069. Epub 2024 Aug 13. |
| Chemical characterization and encapsulation of Ganoderma pfeifferi extract with cytotoxic properties. |
| Šťastný J, Morellá-Aucejo Á, Skala T, Bernardos A, Maršík P, Lérida-Viso A, Matějka J, Mascellani Bergo A, Marcos MD, Martínez-Máñez R, Jablonský I, Klouček P. |
| Front Pharmacol. 2025 Jan 23;16:1526502. doi: 10.3389/fphar.2025.1526502. eCollection 2025. |
| Ganoderma spore lipid ameliorates docetaxel, cisplatin, and 5-fluorouracil chemotherapy-induced damage to bone marrow mesenchymal stem cells and hematopoiesis. |
| Lin H, Chung M, Sun J, Yang Y, Zhang L, Pan X, Wei M, Cai S, Pan Y. |
| BMC Complement Med Ther. 2024 Apr 12;24(1):158. doi: 10.1186/s12906-024-04445-x. |
| The Artist's Conk Medicinal Mushroom Ganoderma applanatum (Agaricomycetes): Mycological, Mycochemical, and Pharmacological Properties: A Review. |
| Cheng M, Zhang L, Wang J, Sun X, Qi Y, Chen L, Han C. |
| Int J Med Mushrooms. 2024;26(7):13-66. doi: 10.1615/IntJMedMushrooms.2024053900. |
| Antrodia cinnamomea Formula Suppresses Prostate Cancer Progression via Immune Modulation and PD-1/PD-L1 Pathway Inhibition. |
| Tsai MY, Lu CK, Shu LH, Liu HT, Wu YH, Lin YS, Yang YH, Shih WT, Lee IY, Wu YH, Wu CY. |
| Int J Mol Sci. 2025 Mar 17;26(6):2684. doi: 10.3390/ijms26062684. |
| Effect of Ganoderma lucidum on Cisplatin-induced Nephrotoxicity and Gastrointestinal Toxicity. |
| Ota N, Endo S, Tatsunami R, Yamaguchi A, Wakame K, Nakata A, Sato K. |
| Anticancer Res. 2024 Aug;44(8):3605-3613. doi: 10.21873/anticanres.17183. |
| Senolytic effect of triterpenoid complex from Ganoderma lucidum on adriamycin-induced senescent human hepatocellular carcinoma cells model in vitro and in vivo. |
| Abdelmoaty AAA, Chen J, Zhang K, Wu C, Li Y, Li P, Xu J. |
| Front Pharmacol. 2024 Sep 19;15:1422363. doi: 10.3389/fphar.2024.1422363. eCollection 2024. |
| Rhizopogon luteolus and Ganoderma adspersum Extracts Inhibit Invasion through the Crosstalk between Anti-oxidant Activity and Apoptosis Induced by pAKT/Rb. |
| Demiray A, Karagür ER, Tel-Cayan G, Tokgün O, Akça H, Duru ME. |
| Anticancer Agents Med Chem. 2025 Jan 13. doi: 10.2174/0118715206349668241118104255. Online ahead of print. |
| The Anti-Melanogenic Effects of Ganodermanontriol from the Medicinal Mushroom Ganoderma lucidum through the Regulation of the CREB and MAPK Signaling Pathways in B16F10 Cells. |
| Park CH, Oh YL, Shin JH, Park YJ. |
| Molecules. 2024 Aug 22;29(16):3976. doi: 10.3390/molecules29163976. |
| Lanostane triterpenoids from Ganoderma calidophilum exhibit potent anti-tumor activity by inhibiting PTP1B. |
| Chen C, Xu R, Guo C, Li X, Zhao Y, Luo D. |
| Chem Biol Interact. 2024 Nov 1;403:111253. doi: 10.1016/j.cbi.2024.111253. Epub 2024 Sep 26. |
| Ganoderma tuberculosum Liquid Culture With Vineyard Pruning Extracts for Bioactive Composite Production With Antiproliferative Activity. |
| Angulo-Sanchez LT, Cruz-Félix MC, Vidal-Gutiérrez M, Torres-Moreno H, Muñoz-Bernal ÓA, Álvarez-Parrilla E, Robles-Zepeda RE, Álvarez-Bajo O, Gutiérrez A, Esqueda M. |
| Adv Pharmacol Pharm Sci. 2024 Oct 24;2024:5245451. doi: 10.1155/2024/5245451. eCollection 2024. |
| Triterpenes from antler-shaped fruiting body of Ganoderma lucidum and their hepatoprotective activities. |
| Shao H, Li Y, Wu C, Chen R, Kang J. |
| Phytochemistry. 2024 Aug;224:114148. doi: 10.1016/j.phytochem.2024.114148. Epub 2024 May 18. |
| Dual inhibitory potential of ganoderic acid A on GLUT1/3: computational and in vitro insights into targeting glucose metabolism in human lung cancer. |
| Bashir MA, Abdalla M, Shao CS, Wang H, Bondzie-Quaye P, Almahi WA, Swallah MS, Huang Q. |
| RSC Adv. 2024 Sep 6;14(39):28569-28584. doi: 10.1039/d4ra04454a. eCollection 2024 Sep 4. |
| Aromatic compounds and organic acids identified from Ganoderma formosanum exhibit synergistic anti-melanogenic effects. |
| Hsieh CC, Hou CY, Lei HY, Khumsupan D, Chai HJ, Lim PK, Hsu CC, Wu SJ, Cheng KW, Chen YC, Cheng KC. |
| J Food Drug Anal. 2024 Dec 15;32(4):532-543. doi: 10.38212/2224-6614.3509. |
| Semisynthesis and antitumor activity of endertiin B and related triterpenoids from Ganoderma lucidum. |
| Liu Y, Wen HK, Xu RX, Liu C, Li XH, Qin XD, Zhao YX, Jia YX, Luo DQ. |
| Org Biomol Chem. 2024 Jun 19;22(24):4978-4986. doi: 10.1039/d4ob00641k. |
| Design, synthesis and biological evaluation of novel curcumin-fluorouracil hybrids as potential anti-cancer agents. |
| Wang X, Li X, Zhang X, Wang X, Yang J, Liu G. |
| Biochem Pharmacol. 2024 Dec;230(Pt 1):116559. doi: 10.1016/j.bcp.2024.116559. Epub 2024 Sep 24. |
| Unveiling the anticancer potential and toxicity of Ganoderma applanatum wild mushroom derived bioactive compounds: An in vitro, in vivo and in silico evaluation. |
| Rijia A, Krishnamoorthi R, Mahalingam PU, Kaviyadharshini M, Rajeswari M, Kumar KKS, Rasmi M, Chung YK, Fang JY. |
| Bioorg Chem. 2025 Mar;156:108233. doi: 10.1016/j.bioorg.2025.108233. Epub 2025 Jan 31. |
| Investigating the therapeutic potential of Ganoderma lucidum in treating optic nerve atrophy through network pharmacology and experimental validation. |
| Zhilin L, Haobo F, Juan W, AiRui X, XiaoDong L, Yuan Y, Junguo D. |
| Biochem Biophys Res Commun. 2025 May 26;760:151702. doi: 10.1016/j.bbrc.2025.151702. Epub 2025 Mar 26. |
| Inhibition of Hepatoblastoma by Ganoderma Lucidum Polysaccharide via the Induction of HDAC4-p16-RB Axis-Mediated Cellular Senescence. |
| Ye T, Ge Y, Zhang J, Gao H, Zhang PC, Shen R, Peng C, Liu B, Song H. |
| Phytother Res. 2025 Apr 6. doi: 10.1002/ptr.8493. Online ahead of print. |
| Ganoderma pfeifferi Bres. and Ganoderma resinaceum Boud. as Potential Therapeutic Agents: A Comparative Study on Antiproliferative and Lipid-Lowering Properties. |
| Rašeta M, Kebert M, Mišković J, Kostić S, Kaišarević S, Stilinović N, Vukmirović S, Karaman M. |
| J Fungi (Basel). 2024 Jul 19;10(7):501. doi: 10.3390/jof10070501. |
| In vitro antitumor effects of methanolic extracts of three Ganoderema mushrooms. |
| Toson EA, El-Fallal AA, Oransa MA, El-Gharabawy HM. |
| Sci Rep. 2025 Jan 17;15(1):2274. doi: 10.1038/s41598-025-86162-0. |
| ATP deficiency triggers ganoderic acids accumulation via fatty acid beta-oxidation pathway in Ganoderma lucidum. |
| Liu W, Sun Y, Yue S, Kong Y, Cong Q, Lan Y, Zhao M, Shi L. |
| Microb Cell Fact. 2025 Mar 11;24(1):62. doi: 10.1186/s12934-025-02668-2. |
| Elucidating the protective mechanism of ganoderic acid DM on breast cancer based on network pharmacology and in vitro experimental validation. |
| Swallah MS, Bondzie-Quaye P, Yu X, Fetisoa MR, Shao CS, Huang Q. |
| Biotechnol Appl Biochem. 2025 Apr;72(2):415-436. doi: 10.1002/bab.2673. Epub 2024 Sep 25. |
| Baoslingzhines Q-X: Structurally previously undescribed trace phenolic meroterpenoids from Ganoderma lucidum and their biological activities toward renal fibrosis and cytotoxicity. |
| Liu YY, Cai D, Tang XP, Cheng YX. |
| Phytochemistry. 2025 Jul;235:114448. doi: 10.1016/j.phytochem.2025.114448. Epub 2025 Feb 19. |
| The active ingredient beta-sitosterol in Ganoderma regulates CHRM2-mediated aerobic glycolysis to induce apoptosis of lung adenocarcinoma cells. |
| Zhao Q, Pan Y, Zhang D, Zhou X, Sun L, Xu Z, Zhang Y. |
| Genes Genet Syst. 2025 Apr 5;100. doi: 10.1266/ggs.24-00108. Epub 2024 Nov 14. |
| Thiazolidinedione-based structure modification of ergosterol peroxide provides thiazolidinedione-conjugated derivatives as potent agents against breast cancer cells through a PI3K/AKT/mTOR pathway. |
| Deng S, Wang L, Tian S, Wu J, Lin Y, Wang H, Guo X, Han C, Ren W, Han YL, Zhou J, Bu M. |
| Bioorg Med Chem. 2025 Jan 1;117:118007. doi: 10.1016/j.bmc.2024.118007. Epub 2024 Nov 19. |
| A nanozyme multifunctional platform based on iron doped carbon dots derived from Tibetan Ganoderma lucidum waste for glucose sensing, anti-counterfeiting applications, and anticancer cell effect. |
| Wang L, Zheng S, Liu Y, Ji Y, Liu X, Wang F, Li C. |
| Talanta. 2024 Aug 15;276:126262. doi: 10.1016/j.talanta.2024.126262. Epub 2024 May 15. |
| Effects of Reishimmune-S, a Fungal Immunomodulatory Peptide Supplement, on the Quality of Life and Circulating Natural Killer Cell Profiles of Patients With Early Breast Cancer Receiving Adjuvant Endocrine Therapy. |
| Su YW, Huang WY, Lin SH, Yang PS. |
| Integr Cancer Ther. 2024 Jan-Dec;23:15347354241242120. doi: 10.1177/15347354241242120. |
| Early Preclinical Studies of Ergosterol Peroxide and Biological Evaluation of Its Derivatives. |
| Ling T, Arroyo-Cruz LV, Smither WR, Seighman EK, Martínez-Montemayor MM, Rivas F. |
| ACS Omega. 2024 Aug 19;9(35):37117-37127. doi: 10.1021/acsomega.4c04350. eCollection 2024 Sep 3. |
| Bioactive components, pharmacological properties and underlying mechanism of Ganoderma lucidum spore oil: A review. |
| Liu J, Zhang B, Wang L, Li S, Long Q, Xiao X. |
| Chin Herb Med. 2024 Jan 17;16(3):375-391. doi: 10.1016/j.chmed.2023.09.007. eCollection 2024 Jul. |
| A review of polysaccharides from Ganoderma lucidum: Preparation methods, structural characteristics, bioactivities, structure-activity relationships and potential applications. |
| Yang M, Qin X, Liu X. |
| Int J Biol Macromol. 2025 Apr;303:140645. doi: 10.1016/j.ijbiomac.2025.140645. Epub 2025 Feb 3. |
| Structure-function insights of natural Ganoderma polysaccharides: advances in biosynthesis and functional food applications. |
| Wu ZW, Zhao XF, Quan CX, Liu XC, Tao XY, Li YJ, Peng XR, Qiu MH. |
| Nat Prod Bioprospect. 2025 Mar 4;15(1):15. doi: 10.1007/s13659-025-00496-w. |
| Extraction, purification, structural characterization, biological activity, mechanism of action and application of polysaccharides from Ganoderma lucidum: A review. |
| Ding L, Shangguan H, Wang X, Liu J, Shi Y, Xu X, Xie Y. |
| Int J Biol Macromol. 2025 Feb;288:138575. doi: 10.1016/j.ijbiomac.2024.138575. Epub 2024 Dec 9. |
| Network pharmacology combined with transcriptomics reveals that Ganoderma lucidum spore and Sanghuangporus vaninii compound extract exerts anti-colorectal cancer effects via CYP24A1-mediated VDR pathway and TERT-mediated Wnt signaling pathway. |
| Huo J, Nie K, Yang T, Zhang S, Zhu Z, Peng X, Zhang Y. |
| J Ethnopharmacol. 2025 Apr 15:119820. doi: 10.1016/j.jep.2025.119820. Online ahead of print. |
| Ganoderma lucidum and Hypericum perforatum Exhibit Anti-Inflammatory, Antioxidant, and Anti-Androgen Effect in Rat Model of Experimental Polycystic Ovarian Syndrome. |
| Okay G, Kırıcı P, Mavral N, Utkan Korun ZE, Annac E, Kaplan S. |
| Med Princ Pract. 2024 Apr 10;33(4):1-7. doi: 10.1159/000538595. Online ahead of print. |
| Screening of active components of Ganoderma lucidum and decipher its molecular mechanism to improve learning and memory disorders. |
| Zhang XT, Ji CL, Fu YJ, Yang Y, Xu GY. |
| Biosci Rep. 2024 Jul 31;44(7):BSR20232068. doi: 10.1042/BSR20232068. |
| Use of Herbal Drugs in Cardiovascular Disease- A Review. |
| Kaur A, Kumar R. |
| Curr Cardiol Rev. 2025;21(1):e1573403X323724. doi: 10.2174/011573403X323724240830075719. |
| Ganoderma atrum polysaccharide inhibits ROS/NLRP3/pyroptosis axis by fixing mitochondrial dynamics disorder in PD-1 inhibitors-induced carditis of Lewis lung carcinoma mice. |
| Mu XY, Chen SB, Yang SY, Wang WS, Zhou HM, Wang YX, Chen XY, Peng XP, Li WJ. |
| Int J Biol Macromol. 2025 Apr 15:143163. doi: 10.1016/j.ijbiomac.2025.143163. Online ahead of print. |
| Neuroprotective and antidiabetic lanostane-type triterpenoids from the fruiting bodies of Ganoderma theaecolum. |
| Guo J, Yang L, Dai L, Ma Q, Yan J, Xie Q, Wu Y, Dai H, Zhao Y. |
| Chin J Nat Med. 2025 Feb;23(2):245-256. doi: 10.1016/S1875-5364(25)60828-4. |
| Ganoderma lucidum spore oil synergistically enhances the function of cyclophosphamide in the prevention of breast cancer metastasis. |
| Lian S, Li W, Zhong C, Li Y, Wu C, Zhang K, Lin J, Wang W, Katanaev V, Xie X, Jia L. |
| J Chin Med Assoc. 2024 Mar 1;87(3):305-313. doi: 10.1097/JCMA.0000000000001038. Epub 2023 Dec 18. |
| [UPLC-Q-TOF-MS/MS qualitative analysis and HPLC determination of triterpenoids in Ganoderma lucidum spores]. |
| Qiao LZ, Lu CN, Liu XQ, Chen LM, Feng WH, Liang YH, Li C, Wang ZM. |
| Zhongguo Zhong Yao Za Zhi. 2024 Oct;49(20):5487-5496. doi: 10.19540/j.cnki.cjcmm.20240714.201. |
| A glucomannan from defatted Ganoderma lucidum spores: structural characterization and immunomodulatory activity via activating TLR4/MyD88/NF-kappaB signaling pathway. |
| Huang J, Su Y, Wang Q, Feng M, Zhang D, Yu Q, Yan C. |
| Int J Biol Macromol. 2025 Mar;294:139195. doi: 10.1016/j.ijbiomac.2024.139195. Epub 2024 Dec 27. |
| [Oscillation-static cycle cultivation enhances the synthesis of triterpenes and mycelium activity in Ganoderma lucidum]. |
| Jiang X, Han W, Guo J, Liu Y, Xu A, Tang C, Feng J, Zhang J. |
| Sheng Wu Gong Cheng Xue Bao. 2024 Sep 25;40(9):3189-3200. doi: 10.13345/j.cjb.230883. |
| Effects of Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Triterpene on Motor and Spatial Learning Disorders in 5xFAD Mice. |
| Zhang C, Ye Y, Wang W, Wang C, Gao P, Wan P. |
| Int J Med Mushrooms. 2025;27(4):21-37. doi: 10.1615/IntJMedMushrooms.2024057835. |
| In vitro evaluation of the antitumor and antioxidant effects of purified and characterized polysaccharides from Ganoderma applanatum. |
| Ni DR, Li HY, Li ZP, Liu JW. |
| Ann Med. 2024 Dec;56(1):2411010. doi: 10.1080/07853890.2024.2411010. Epub 2024 Nov 16. |
| Integrated Transcriptomic and Targeted Metabolomic Analysis Reveals the Key Genes Involved in Triterpenoid Biosynthesis of Ganoderma lucidum. |
| Xu X, Li C, Wu F, Zhao S, Chen T, You H, Lin Y, Zou X. |
| J Fungi (Basel). 2025 Jan 13;11(1):57. doi: 10.3390/jof11010057. |
| Mechanistic and Functional Studies on the Microbial Induction of Wolfiporia cocos Liquid Fermentation Products. |
| Yang Z, Su C, Xu Z, Liu Y, Chen J, Wu X. |
| Foods. 2024 May 18;13(10):1578. doi: 10.3390/foods13101578. |
| Broad-spectrum antiviral activity of Ganoderma microsporum immunomodulatory protein: Targeting glycoprotein gB to inhibit EBV and HSV-1 infections via viral fusion blockage. |
| Vo DNK, Ho HPT, Wu LS, Chen YY, Trinh HTV, Lin TY, Lim YY, Tsai KC, Tsai MH. |
| Int J Biol Macromol. 2025 Mar 16;307(Pt 3):142179. doi: 10.1016/j.ijbiomac.2025.142179. Online ahead of print. |
| Oral Administration of Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Extract Protects Gingival Tissues against Proinflammatory TNF-alpha and Oxidative Stress in Periodontitis Model Rats. |
| Hossain S, Rahman MA, Uddin B, Nahar T, Sarkar M, Joy SI, Baraik A. |
| Int J Med Mushrooms. 2024;26(8):1-11. doi: 10.1615/IntJMedMushrooms.2024053946. |
| Antiproliferative and Antibacterial Activity of Polyporoid Fungi from Veracruz, Mexico. |
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| Int J Med Mushrooms. 2024;26(5):73-86. doi: 10.1615/IntJMedMushrooms.2024052840. |
| Ganoderma lucidum dry extract supplementation modulates T lymphocyte function in older women. |
| Iser-Bem PN, Lobato TB, Alecrim-Zeza AL, Dos Santos de Oliveira LC, Passos MEP, Manuel R, Diniz VLS, Correa IS, de Oliveira SP, Silva EBD, Almeida MM, Dias BB, Gritte RB, Levada-Pires AC, Masi LN, Hatanaka E, Pithon-Curi TC, Hirabara SM, Fabi JP, Curi R, Gorjao R. |
| Br J Nutr. 2024 Jul 28;132(2):130-140. doi: 10.1017/S0007114524001144. Epub 2024 May 27. |
| Ganoderma Lucidum polysaccharide peptide (GL-PP2): A potential therapeutic agent against sepsis-induced organ injury by modulating Nrf2/NF-kappaB pathways. |
| Yang T, Fang H, Lin D, Yang S, Luo H, Wang L, Yang B. |
| Int J Biol Macromol. 2025 Jan;285:138378. doi: 10.1016/j.ijbiomac.2024.138378. Epub 2024 Dec 4. |
| Ganoderma lucidum polysaccharide alleviates cognitive dysfunction by inhibiting neuroinflammation via NLRP3/NF-kappaB signaling pathway. |
| Jiang Y, Wang Z, Wang W, Liu Y, Meng Y, Wang Y, Fan M, Cai C. |
| J Ethnopharmacol. 2025 Feb 10;338(Pt 2):119065. doi: 10.1016/j.jep.2024.119065. Epub 2024 Nov 8. |
| Effects of Ganoderma lucidum Powder on the Growth Performance, Immune Organ Weights, Cecal Microbiology, Serum Immunoglobulins, and Tibia Minerals of Broiler Chickens. |
| Avain A, Azad MAK, García Y, García Y, Martínez Y. |
| Vet Sci. 2024 Dec 22;11(12):675. doi: 10.3390/vetsci11120675. |
| The Addition of Hot Water Extract of Juncao-Substrate Ganoderma lucidum Residue to Diets Enhances Growth Performance, Immune Function, and Intestinal Health in Broilers. |
| Gao YY, Liu XP, Zhou YH, He JY, Di B, Zheng XY, Guo PT, Zhang J, Wang CK, Jin L. |
| Animals (Basel). 2024 Oct 11;14(20):2926. doi: 10.3390/ani14202926. |
| Bioactivities and industrial standardization status of Ganoderma lucidum: A comprehensive review. |
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| Heliyon. 2024 Aug 29;10(19):e36987. doi: 10.1016/j.heliyon.2024.e36987. eCollection 2024 Oct 15. |
| Extraction Optimization and Bioactivity of Polysaccharides from Ganoderma leucocontextum Spores. |
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| Pharmaceuticals (Basel). 2025 Feb 11;18(2):241. doi: 10.3390/ph18020241. |
| Integrating transcriptomics, metabolomics, and network pharmacology to investigate multi-target effects of sporoderm-broken spores of Ganoderma lucidum on improving HFD-induced diabetic nephropathy rats. |
| Hu L, Yu L, Cao Z, Wang Y, Zhu C, Li Y, Yin J, Ma Z, He X, Zhang Y, Huang W, Guan Y, Chen Y, Li X, Chen X. |
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| Mushrooms as Nutritional Powerhouses: A Review of Their Bioactive Compounds, Health Benefits, and Value-Added Products. |
| Singh A, Saini RK, Kumar A, Chawla P, Kaushik R. |
| Foods. 2025 Feb 22;14(5):741. doi: 10.3390/foods14050741. |
| Protective effects of Ganoderma lucidum spores on estradiol benzoate-induced TEC apoptosis and compromised double-positive thymocyte development. |
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| Front Pharmacol. 2024 Aug 16;15:1419881. doi: 10.3389/fphar.2024.1419881. eCollection 2024. |
| Improvement of Echinacea purpurea and Ganoderma lucidum Extracts with Cell Model on Influenza A/B Infection. |
| Chen BK, Chan CH, Tsao A, Wang CK. |
| Molecules. 2024 Jul 30;29(15):3609. doi: 10.3390/molecules29153609. |
| Biphasic Fermentation of Trapa bispinosa Shells by Ganoderma sinense and Characterization of Its Polysaccharides and Alcoholic Extract and Analysis of Their Bioactivity. |
| Sun X, Lei Q, Chen Q, Song D, Zhou M, Wang H, Wang L. |
| Molecules. 2024 Mar 11;29(6):1238. doi: 10.3390/molecules29061238. |
| Functional characterization of Ganoderma lucidum polysaccharide and the mechanism of inducing tomato resistance to Tomato yellow leaf curl virus. |
| Fu H, Yang X, Han S, Wang K, Wang H. |
| Int J Biol Macromol. 2025 Apr;303:140617. doi: 10.1016/j.ijbiomac.2025.140617. Epub 2025 Feb 2. |
| (1)H NMR analysis of metabolites from leaf tissue of resistant and susceptible oil palm breeding materials against Ganoderma boninense. |
| Rahmadi HY, Syukur M, Widodo, Suwarno WB, Wening S, Simamora AN, Nugroho S. |
| Metabolomics. 2024 Aug 2;20(5):89. doi: 10.1007/s11306-024-02160-9. |
| Deciphering root-associated microbial communities in asymptomatic oil palm seedlings exposed to Ganoderma boninense: new insight into disease tolerance of oil palms. |
| Ho L, Lai C, Daim LDJ, Noh NM, Yap Y, Ibrahim J, Teh C. |
| FEMS Microbiol Ecol. 2024 Sep 14;100(10):fiae122. doi: 10.1093/femsec/fiae122. |
| Effects of Plant Polysaccharides Combined with Boric Acid on Digestive Function, Immune Function, Harmful Gas and Heavy Metal Contents in Faeces of Fatteners. |
| Deng J, Zhang F, Fan H, Zheng Y, Zhao C, Ren M, Jin E, Gu Y. |
| Animals (Basel). 2024 May 21;14(11):1515. doi: 10.3390/ani14111515. |
| The fungal protein Lingzhi-8 ameliorates psoriasis-like dermatitis in mice through gut CD103+ tolerogenic dendritic cells, retinaldehyde dehydrogenase 2, and Dectin-1. |
| Wang CY, Wang JY, Chou YY, Lin CC, Lin YT, Wu CS, Lin JS, Chu CL. |
| Biomed Pharmacother. 2025 Mar;184:117910. doi: 10.1016/j.biopha.2025.117910. Epub 2025 Feb 16. |
| Ganoderic Acid A Prevented Osteoporosis by Modulating the PIK3CA/p-Akt/TWIST1 Signaling Pathway. |
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| Food Sci Nutr. 2025 Apr 14;13(4):e70177. doi: 10.1002/fsn3.70177. eCollection 2025 Apr. |
| UPLC-ESI-MS/MS-based widely targeted metabolomics reveals differences in metabolite composition among four Ganoderma species. |
| Wei-Ye L, Hong-Bo G, Rui-Heng Y, Ai-Guo X, Jia-Chen Z, Zhao-Qian Y, Wen-Jun H, Xiao-Dan Y. |
| Front Nutr. 2024 Mar 18;11:1335538. doi: 10.3389/fnut.2024.1335538. eCollection 2024. |
| Identification of sedative-hypnotic compounds shared by five medicinal Polyporales mushrooms using UPLC-Q-TOF-MS/MS-based untargeted metabolomics. |
| Chen W, Yu JW, Deng YY, Wong LY, Wang C, Liang YL, Leung YT, Tian JY, Wu Y, Leung KS, Hu J, Chen WH, Dou X, Fu XQ, Chen YJ, Yu ZL. |
| Phytomedicine. 2024 Jan 12;128:155355. doi: 10.1016/j.phymed.2024.155355. Online ahead of print. |
| Synergy of de-walled Ganoderma Lucidum spore powder (GLSP) on targeted therapy in advanced non-squamous non-small cell lung cancer with epidermal growth factor receptor (EGFR) mutant: protocol for a randomized, double-blind, placebo-controlled study. |
| Wu TT, Chen YY, Yuan ZC, Yang GW, Zhang GL. |
| BMC Complement Med Ther. 2024 Mar 18;24(1):125. doi: 10.1186/s12906-024-04416-2. |
| Sporoderm-broken spores of Ganoderma lucidum modulate hepatoblastoma malignancy by regulating RACK1-mediated autophagy and tumour immunity. |
| Shen R, Ge Y, Qin Y, Gao H, Yu H, Wu H, Song H. |
| J Cell Mol Med. 2024 Mar;28(6):e18223. doi: 10.1111/jcmm.18223. |
| The Efficacy of Ganoderma lucidum Extracts on Treating Endometrial Cancer: A Network Pharmacology Approach. |
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| Reprod Sci. 2024 Mar 6. doi: 10.1007/s43032-024-01500-3. Online ahead of print. |
| Exploring the Therapeutic Potential of Ganoderma lucidum in Cancer. |
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| J Clin Med. 2024 Feb 18;13(4):1153. doi: 10.3390/jcm13041153. |
| Survival Benefits of Ganoderma Lucidum in Early-stage Triple-negative Breast Cancer: A Real World Study. |
| Jiang B, Li N, Du W, Zeng L, Tang Y, Luo L, Zhu H, Ye F. |
| Recent Pat Anticancer Drug Discov. 2024 Feb 20. doi: 10.2174/0115748928282946240111114448. Online ahead of print. |
| EFFECT OF DRY EXTRACT FROM REISHI MUSHROOMS ON THE STATE OF ANTIOXIDANT SYSTEM IN RATS WITH DMH-INDUCED COLON CARCINOGENESIS. |
| Herasymets I, Fira L, Medvid I, Fira D, Yasinovskyi O, Grytsyshyn L. |
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| Medicinal Mushrooms (PDQ®): Health Professional Version. |
| PDQ Integrative, Alternative, and Complementary Therapies Editorial Board. |
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| Identification a novel Ganoderma FIP gene from Ganoderma capense and its functional expression in Pichia pastoris. |
| Lin J, Liao Y, Yang S, Jin T, Yu B, Zhao K, Sai Y, Lin C, Song Y, Ma H, Wang Z. |
| World J Microbiol Biotechnol. 2024 Jan 16;40(2):69. doi: 10.1007/s11274-023-03869-w. |
| Ganoderma microsporum immunomodulatory protein combined with KRAS(G12C) inhibitor impedes intracellular AKT/ERK network to suppress lung cancer cells with KRAS mutation. |
| Hua WJ, Hwang WL, Yeh H, Lin ZH, Hsu WH, Lin TY. |
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| Antiproliferative Activity of Gibbosic Acid H through Induction of G(0)/G(1) Cell Cycle Arrest and Apoptosis in Human Lung Cancer Cells. |
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| J Cancer Prev. 2023 Dec 30;28(4):201-211. doi: 10.15430/JCP.2023.28.4.201. |
| Ganoderma lucidum spore oil synergistically enhances the function of cyclophosphamide in the prevention of breast cancer metastasis. |
| Lian S, Li W, Zhong C, Li Y, Wu C, Zhang K, Lin J, Wang W, Katanaev V, Xie X, Jia L. |
| J Chin Med Assoc. 2024 Mar 1;87(3):305-313. doi: 10.1097/JCMA.0000000000001038. Epub 2023 Dec 18. |
| Exploring the anti-cancer potential of Ganoderma lucidum polysaccharides (GLPs) and their versatile role in enhancing drug delivery systems: a multifaceted approach to combat cancer. |
| Gao X, Homayoonfal M. |
| Cancer Cell Int. 2023 Dec 16;23(1):324. doi: 10.1186/s12935-023-03146-8. |
| Natural Bio-Compounds from Ganoderma lucidum and Their Beneficial Biological Actions for Anticancer Application: A Review. |
| Cadar E, Negreanu-Pirjol T, Pascale C, Sirbu R, Prasacu I, Negreanu-Pirjol BS, Tomescu CL, Ionescu AM. |
| Antioxidants (Basel). 2023 Oct 25;12(11):1907. doi: 10.3390/antiox12111907. |
| Improving nanochemoimmunotherapy efficacy by boosting "eat-me" signaling and downregulating "don't-eat-me" signaling with Ganoderma lucidum polysaccharide-based drug delivery. |
| Pang G, Wei S, Zhao J, Wang FJ. |
| J Mater Chem B. 2023 Dec 13;11(48):11562-11577. doi: 10.1039/d3tb02118a. |
| GMI, a Ganoderma microsporum protein, abolishes focal adhesion network to reduce cell migration and metastasis of lung cancer. |
| Lo HC, Hua WJ, Yeh H, Lin ZH, Huang LC, Ciou YR, Ruan R, Lin KF, Tseng AJ, Wu ATH, Hsu WH, Chao CH, Lin TY. |
| Life Sci. 2023 Dec 15;335:122255. doi: 10.1016/j.lfs.2023.122255. Epub 2023 Nov 14. |
| Characterization and Biological Studies of the Terpenoids from Ganoderma resinaceum and Serpula similis (Agaricomycetes). |
| Rikame TN, Ranawade PS, Mittal SPK, Barvkar VT, Borde MY, Tak RD. |
| Int J Med Mushrooms. 2023;25(12):15-31. doi: 10.1615/IntJMedMushrooms.2023050771. |
| The effect of Ganoderma lucidum polysaccharide extract on sensitizing prostate cancer cells to flutamide and docetaxel: an in vitro study. |
| Rahimnia R, Akbari MR, Yasseri AF, Taheri D, Mirzaei A, Ghajar HA, Farashah PD, Baghdadabad LZ, Aghamir SMK. |
| Sci Rep. 2023 Nov 2;13(1):18940. doi: 10.1038/s41598-023-46118-8. |
| A Comprehensive Review on the Chemical Composition, Pharmacology and Clinical Applications of Ganoderma. |
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| Am J Chin Med. 2023;51(8):1983-2040. doi: 10.1142/S0192415X23500878. Epub 2023 Oct 31. |
| Ganoderma microsporum immunomodulatory protein as an extracellular epidermal growth factor receptor (EGFR) degrader for suppressing EGFR-positive lung cancer cells. |
| Hua WJ, Yeh H, Lin ZH, Tseng AJ, Huang LC, Qiu WL, Tu TH, Wang DH, Hsu WH, Hwang WL, Lin TY. |
| Cancer Lett. 2023 Dec 1;578:216458. doi: 10.1016/j.canlet.2023.216458. Epub 2023 Oct 20. |
| Ganoderma lucidum methanolic extract as a potent phytoconstituent: characterization, in-vitro antimicrobial and cytotoxic activity. |
| Mousavi SM, Hashemi SA, Gholami A, Omidifar N, Chiang WH, Neralla VR, Yousefi K, Shokripour M. |
| Sci Rep. 2023 Oct 13;13(1):17326. doi: 10.1038/s41598-023-44135-1. |
| Studies of Antioxidant and Cytotoxic Activity in Ready-to-Drink Wild Ganoderma Teas: An In Vitro Approach. |
| Ghosh S, Das S, Saha R, Acharya K. |
| Int J Med Mushrooms. 2023;25(11):53-63. doi: 10.1615/IntJMedMushrooms.2023050232. |
| Biological Activity of Ganoderma Species (Agaricomycetes) from Sonoran Desert, Mexico. |
| Bacallao-Escudero A, Guerrero-Germán P, Torres-Moreno H, Vidal-Gutiérrez M, López-Romero JC, Tejeda-Mansir A, Esqueda M, Robles-Zepeda RE. |
| Int J Med Mushrooms. 2023;25(10):65-76. doi: 10.1615/IntJMedMushrooms.2023049938. |
| Apoptosis-Mediated Anticancer Activity of Ganoderma colossus (Agaricomycetes) Extracts in Breast Cancer Cells. |
| E R, Naik P, N KM, Laha S. |
| Int J Med Mushrooms. 2023;25(10):23-37. doi: 10.1615/IntJMedMushrooms.2023049907. |
| G. lucidum triterpenes restores intestinal flora balance in non-hepatitis B virus-related hepatocellular carcinoma: evidence of 16S rRNA sequencing and network pharmacology analysis. |
| Xiong W, Yang C, Xia J, Wang W, Li N. |
| Front Pharmacol. 2023 Sep 18;14:1197418. doi: 10.3389/fphar.2023.1197418. eCollection 2023. |
| Pharmacological Activities and Safety of Ganoderma lucidum Spores: A Systematic Review. |
| Thuy NHL, Tu VL, Thu LNA, Giang TT, Huyen DTK, Loc DH, Tam DNH, Phat NT, Huynh HH, Truyen TTTT, Nguyen QH, Do U, Nguyen D, Dat TV, Minh LHN. |
| Cureus. 2023 Sep 2;15(9):e44574. doi: 10.7759/cureus.44574. eCollection 2023 Sep. |
| The medicinal mushroom Ganoderma lucidum prevents lung tumorigenesis induced by tobacco smoke carcinogens. |
| Shahid A, Chen M, Yeung S, Parsa C, Orlando R, Huang Y. |
| Front Pharmacol. 2023 Sep 6;14:1244150. doi: 10.3389/fphar.2023.1244150. eCollection 2023. |
| Thermal/ultrasound-triggered release of liposomes loaded with Ganoderma applanatum polysaccharide from microbubbles for enhanced tumour ablation. |
| Yuan J, Ding L, Han L, Pang L, Zhang P, Yang X, Liu H, Zheng M, Zhang Y, Luo W. |
| J Control Release. 2023 Nov;363:84-100. doi: 10.1016/j.jconrel.2023.09.030. Epub 2023 Sep 25. |
| Lanostane triterpenoids with anti-proliferative and PTP1B/alpha-glucosidase inhibitory activities from the fruiting bodies of Ganoderma calidophilum. |
| Yang L, Zhang TT, Ma QY, Xie QY, Guo JC, Lu JJ, Yu ZF, Dai HF, Zhao YX. |
| Phytochemistry. 2023 Nov;215:113856. doi: 10.1016/j.phytochem.2023.113856. Epub 2023 Sep 15. |
| Assessment of redox homeostasis via genotoxicity, cytotoxicity, apoptosis and NRF-2 in colorectal cancer cell lines after treatment with Ganoderma lucidum extract. |
| Tülüce Y, Keleş AY, Köstekci S. |
| Drug Chem Toxicol. 2023 Sep 13:1-17. doi: 10.1080/01480545.2023.2257403. Online ahead of print. |
| Potentialities of Ganoderma lucidum extracts as functional ingredients in food formulation. |
| Sharif Swallah M, Bondzie-Quaye P, Wang H, Shao CS, Hua P, Alrasheed Bashir M, Benjamin Holman J, Sossah FL, Huang Q. |
| Food Res Int. 2023 Oct;172:113161. doi: 10.1016/j.foodres.2023.113161. Epub 2023 Jun 18. |
| A natural biomaterial promotes hybridization chain reaction for ultra-sensitive detection of miRNA-155. |
| Bian Y, Li M, Wu Z, Weng J, Zeng R, Sun L. |
| Talanta. 2024 Jan 1;266(Pt 2):125117. doi: 10.1016/j.talanta.2023.125117. Epub 2023 Aug 23. |
| A review of anti-tumour effects of Ganoderma lucidum in gastrointestinal cancer. |
| Ye T, Ge Y, Jiang X, Song H, Peng C, Liu B. |
| Chin Med. 2023 Aug 28;18(1):107. doi: 10.1186/s13020-023-00811-y. |
| Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer. |
| Gariboldi MB, Marras E, Ferrario N, Vivona V, Prini P, Vignati F, Perletti G. |
| Int J Mol Sci. 2023 Jun 14;24(12):10120. doi: 10.3390/ijms241210120. |
| Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma. |
| Folgado-Dorado C, Caracena-De La Corte J, Aguilera-Velázquez JR, Santana-Villalona R, Rivera-Ramos A, Carbonero-Aguilar MP, Talaverón R, Bautista J, Sarmiento Soto M. |
| J Vis Exp. 2023 Jun 2;(196). doi: 10.3791/64924. |
| Lucialdehyde B suppresses proliferation and induces mitochondria-dependent apoptosis in nasopharyngeal carcinoma CNE2 cells. |
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| Pharm Biol. 2023 Dec;61(1):918-926. doi: 10.1080/13880209.2023.2220754. |
| Medicinal Mushrooms (PDQ®): Patient Version. |
| PDQ Integrative, Alternative, and Complementary Therapies Editorial Board. |
| 2023 Jun 8. In: PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002–. |
| Significance of culture period on the physiochemistry and anti-cancer potentials of polysaccharides from mycelia of Ganoderma lucidum. |
| Qiu WL, Lo HC, Lu MK, Lin TY. |
| Int J Biol Macromol. 2023 Jul 1;242(Pt 4):125181. doi: 10.1016/j.ijbiomac.2023.125181. Epub 2023 Jun 1. |
| Polysaccharide of Ganoderma lucidum Ameliorates Cachectic Myopathy Induced by the Combination Cisplatin plus Docetaxel in Mice. |
| Wu SY, Ou CC, Lee ML, Hsin IL, Kang YT, Jan MS, Ko JL. |
| Microbiol Spectr. 2023 Jun 15;11(3):e0313022. doi: 10.1128/spectrum.03130-22. Epub 2023 May 22. |
| In vitro anti-Toxoplasma gondii activity of Ganoderma lucidum extracts. |
| Ahmadi M, Salimi M, Saraei M, Nezhad NS, Javadi A, Mohammadi F, Heydarian P, Ali E, Hajialilo E. |
| BMC Res Notes. 2023 May 18;16(1):82. doi: 10.1186/s13104-023-06355-6. |
| Aqueous-soluble components of sporoderm-removed Ganoderma lucidum spore powder promote ferroptosis in oral squamous cell carcinoma. |
| Wu X, Wu Q, Wang Y, Liu Y, Li Z, Liu Q, Huang Z, Li M, Zhang B, Zhan Q. |
| Chin J Cancer Res. 2023 Apr 30;35(2):176-190. doi: 10.21147/j.issn.1000-9604.2023.02.07. |
| CD8(+) T Cell-Mediated Therapeutic Antitumor Effect of an Herbal Mixture Containing Ganoderma lucidum. |
| Takaku S, Shimizu M, Morita R. |
| Evid Based Complement Alternat Med. 2023 Apr 28;2023:9630816. doi: 10.1155/2023/9630816. eCollection 2023. |
| Ganoderma lucidum: Novel Insight into Hepatoprotective Potential with Mechanisms of Action. |
| Ahmad MF, Ahmad FA, Zeyaullah M, Alsayegh AA, Mahmood SE, AlShahrani AM, Khan MS, Shama E, Hamouda A, Elbendary EY, Attia KAHA. |
| Nutrients. 2023 Apr 13;15(8):1874. doi: 10.3390/nu15081874. |
| Biosynthesis and Bioapplications of Nanomaterials from Mushroom Products. |
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| Curr Pharm Des. 2023;29(13):1002-1008. doi: 10.2174/1381612829666230417083133. |
| Evaluating the Application Potential of a Recombinant Ganoderma Protein as Bioactive Ingredients in Cosmetics. |
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| Molecules. 2023 Apr 6;28(7):3272. doi: 10.3390/molecules28073272. |
| Meroterpenoids from Ganoderma petchii inhibiting migration of triple negative breast cancer cells. |
| Zhang JJ, Guo PX, Yang ZH, Cai D, Dai WF, Lu Q, Cheng YX. |
| Fitoterapia. 2023 Jun;167:105505. doi: 10.1016/j.fitote.2023.105505. Epub 2023 Apr 7. |
| Exploring Edible Mushrooms for Diabetes: Unveiling Their Role in Prevention and Treatment. |
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| Molecules. 2023 Mar 21;28(6):2837. doi: 10.3390/molecules28062837. |
| Isolation and Characterization of trans-p-Hydroxycinnamoyl Meroterpenoids from Ganoderma sinensis. |
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| Chem Biodivers. 2023 Apr;20(4):e202300022. doi: 10.1002/cbdv.202300022. Epub 2023 Mar 27. |
| Synergistic apoptotic effects of ethanolic extracts of ginger and Ganoderma lucidum in a colorectal cancer cell line. |
| Saeedifar AM, Ghazavi A, Mosayebi G, Ganji A. |
| Biotech Histochem. 2023 Nov;98(5):353-359. doi: 10.1080/10520295.2023.2190620. Epub 2023 Mar 27. |
| Colorectal cancer inhibitory properties of polysaccharides and their molecular mechanisms: A review. |
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| Structural diversity, fermentation production, bioactivities and applications of triterpenoids from several common medicinal fungi: Recent advances and future perspectives. |
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| Antitumor Activity of Extracts from Medicinal Basidiomycetes Mushrooms. |
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| Mannose Receptor Mediates the Immune Response to Ganoderma atrum Polysaccharides in Macrophages. |
| Li WJ, Tang XF, Shuai XX, Jiang CJ, Liu X, Wang LF, Yao YF, Nie SP, Xie MY. |
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| Enhanced Release of Immunostimulating β-1,3- Glucan by Autodigestion of the Lingzhi Medicinal Mushroom, Ganoderma lingzhi (Agaricomycetes). |
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| Anticancer and Anti-Inflammatory Properties of Ganoderma lucidum Extract Effects on Melanoma and Triple-Negative Breast Cancer Treatment. |
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| Nutrients. 2017 Feb 28;9(3). pii: E210. doi: 10.3390/nu9030210. |
| Sesquiterpenoids from the cultured mycelia of Ganoderma capense. |
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| Fitoterapia. 2017 Feb 21;118:73-79. doi: 10.1016/j.fitote.2017.02.007. |
| Induction of Cbl-dependent epidermal growth factor receptor degradation in Ling Zhi-8 suppressed lung cancer. |
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| Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum: a randomized, double-blind placebo-controlled crossover study of its antioxidation and hepatoprotective efficacy in healthy volunteers. |
| Chiu HF, Fu HY, Lu YY, Han YC, Shen YC, Venkatakrishnan K, Golovinskaia O, Wang CK. |
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| Three new triterpenoids from Ganoderma theaecolum. |
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| Elimination of quiescent slow-cycling cells via reducing quiescence depth by natural compounds purified from Ganoderma lucidum. |
| Dai J, Miller MA, Everetts NJ, Wang X, Li P, Li Y, Xu JH, Yao G. |
| Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14634 |
| A Summary of a Cochrane Review: Ganoderma lucidum (Reishi mushroom) for the treatment of cancer. |
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| Eur J Integr Med. 2016 Oct;8(5):619-620. doi: 10.1016/j.eujim.2016.07.025. Epub 2016 Jul 20. No abstract available. |
| Tubulin polymerization-stimulating activity of Ganoderma triterpenoids. |
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| Partial contribution of Rho-kinase inhibition to the bioactivity of Ganoderma lingzhi and its isolated compounds: insights on discovery of natural Rho-kinase inhibitors. |
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| Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure-activity relationships. |
| Chen S, Li X, Yong T, Wang Z, Su J, Jiao C, Xie Y, Yang BB. |
| Oncotarget. 2017 Feb 7;8(6):10071-10084. doi: 10.18632/oncotarget.14336. |
| Ganoderma lucidum total triterpenes induce apoptosis in MCF-7 cells and attenuate DMBA induced mammary and skin carcinomas in experimental animals. |
| Smina TP, Nitha B, Devasagayam TP, Janardhanan KK. |
| Mutat Res. 2017 Jan;813:45-51. doi: 10.1016/j.mrgentox.2016.11.010. Epub 2016 Dec 2. |
| In Silico Analysis of Lanostanoids Characterized in Ganoderma Mushrooms (Agaricomycetes) as Potential Ligands of the Vitamin D Receptor. |
| Suarez-Medellin J, Meza-Menchaca T, Carranza JA, Trigos A, Vidal-Limon AM. |
| Int J Med Mushrooms. 2016;18(11):1037-1047. doi: 10.1615/IntJMedMushrooms.v18.i11.80. |
| Antitumor Activity of Extracts from Medicinal Basidiomycetes Mushrooms. |
| Vetchinkina E, Shirokov A, Bucharskaya A, Navolokin N, Prilepskii A, Burov A, Maslyakova G, Nikitina VE. |
| Int J Med Mushrooms. 2016;18(11):955-964. doi: 10.1615/IntJMedMushrooms.v18.i11.10. |
| Restoration of the tumor-suppressor function to mutant p53 by Ganoderma lucidum polysaccharides in colorectal cancer cells. |
| Jiang D, Wang L, Zhao T, Zhang Z, Zhang R, Jin J, Cai Y, Wang F. |
| Oncol Rep. 2017 Jan;37(1):594-600. doi: 10.3892/or.2016.5246. Epub 2016 Nov 15. |
| Fucose-containing fraction of Ling-Zhi enhances lipid rafts-dependent ubiquitination of TGFβ receptor degradation and attenuates breast cancer tumorigenesis. |
| Tsao SM, Hsu HY. |
| Sci Rep. 2016 Nov 10;6:36563. doi: 10.1038/srep36563. |
| Immunomodulatory proteins FIP-gts and chloroquine induce caspase-independent cell death via autophagy for resensitizing cisplatin-resistant urothelial cancer cells. |
| Hsin IL, Wang SC, Li JR, Ciou TC, Wu CH, Wu HM, Ko JL. |
| Phytomedicine. 2016 Dec 1;23(13):1566-1573. doi: 10.1016/j.phymed.2016.09.003. Epub 2016 Sep 10. |
| Effects of Ganodermanondiol, a New Melanogenesis Inhibitor from the Medicinal Mushroom Ganoderma lucidum. |
| Kim JW, Kim HI, Kim JH, Kwon OC, Son ES, Lee CS, Park YJ. |
| Int J Mol Sci. 2016 Oct 27;17(11). pii: E1798. |
| New lanostane-type triterpenoids from the fruiting body of Ganoderma hainanense. |
| Li W, Lou LL, Zhu JY, Zhang JS, Liang AA, Bao JM, Tang GH, Yin S. |
| Fitoterapia. 2016 Dec;115:24-30. doi: 10.1016/j.fitote.2016.09.010. Epub 2016 Sep 28. |
| The anti-cancer components of <i>Ganoderma lucidum</i> possesses cardiovascular protective effect by regulating circular RNA expression. |
| Xie YZ, Yang F, Tan W, Li X, Jiao C, Huang R, Yang BB. |
| Oncoscience. 2016 Aug 28;3(7-8):203-207. eCollection 2016 Aug 28. |
| Ganoderma Lucidum (Reishi Mushroom) and cancer. |
| Unlu A, Nayir E, Kirca O, Ozdogan M. |
| J BUON. 2016 Jul-Aug;21(4):792-798. Review. |
| Sporoderm-Broken Spores of Ganoderma lucidum Inhibit the Growth of Lung Cancer: Involvement of the Akt/mTOR Signaling Pathway. |
| Chen Y, Lv J, Li K, Xu J, Li M, Zhang W, Pang X. |
| Nutr Cancer. 2016 Oct;68(7):1151-60. doi: 10.1080/01635581.2016.1208832. Epub 2016 Aug 11. |
| Ganoderic acid targeting multiple receptors in cancer: in silico and in vitro study. |
| Gill BS, Navgeet, Kumar S. |
| Tumour Biol. 2016 Oct;37(10):14271-14290. Epub 2016 Sep 3. |
| Colossolactone H, a new Ganoderma triterpenoid exhibits cytotoxicity and potentiates drug efficacy of gefitinib in lung cancer. |
| Chen SY, Chang CL, Chen TH, Chang YW, Lin SB. |
| Fitoterapia. 2016 Oct;114:81-91. doi: 10.1016/j.fitote.2016.08.015. Epub 2016 Aug 27. |
| Ganoderic Acid A Targeting β-Catenin in Wnt Signaling Pathway: In Silico and In Vitro Study. |
| Gill BS, Kumar S, Navgeet. |
| Interdiscip Sci. 2016 Aug 22. |
| A Ribonuclease Isolated from Wild Ganoderma Lucidum Suppressed Autophagy and Triggered Apoptosis in Colorectal Cancer Cells. |
| Dan X, Liu W, Wong JH, Ng TB. |
| Front Pharmacol. 2016 Jul 25;7:217. doi: 10.3389/fphar.2016.00217. eCollection 2016 Jul 25. |
| Immunomodulatory properties of medicinal mushrooms: differential effects of water and ethanol extracts on NK cell-mediated cytotoxicity. |
| Lu CC, Hsu YJ, Chang CJ, Lin CS, Martel J, Ojcius DM, Ko YF, Lai HC, Young JD. |
| Innate Immun. 2016 Oct;22(7):522-33. doi: 10.1177/1753425916661402. Epub 2016 Jul 28. |
| Characterisation of a New Fungal Immunomodulatory Protein from Tiger Milk mushroom, Lignosus rhinocerotis. |
| Pushparajah V, Fatima A, Chong CH, Gambule TZ, Chan CJ, Ng ST, Tan CS, Fung SY, Lee SS, Tan NH, Lim RL. |
| Sci Rep. 2016 Jul 27;6:30010. doi: 10.1038/srep30010. |
| Triterpenes in cancer: significance and their influence. |
| Gill BS, Kumar S, Navgeet. |
| Mol Biol Rep. 2016 Sep;43(9):881-96. doi: 10.1007/s11033-016-4032-9. Epub 2016 Jun 25. Review. |
| Effect of exopolysaccharide from Ganoderma applanatum on the electrical properties of mouse fibroblast cells line L929 culture using an electric cell-substrate impedance sensing (ECIS) - Preliminary study. |
| Prendecka M, Mlak R, Jaszek M, Osińska-Jaroszuk M, Jakubiak-Hulicz M, Leibold C, Bieser A, Wójcik W, Małecka-Massalska T. |
| Ann Agric Environ Med. 2016 Jun 2;23(2):280-4. doi: 10.5604/12321966.1203891. |
| [Antitumor Effect of Ganoderma lipsiense Extract on Triple-negative Breast Cancer Model Mice and Mechanism Study]. |
| Qi ZH, Meng J, Wang ZL, Sun HZ, Gong Y. |
| Zhongguo Zhong Xi Yi Jie He Za Zhi. 2016 Mar;36(3):366-9. Chinese. |
| Structure Identification and Anti-Cancer Pharmacological Prediction of Triterpenes from Ganoderma lucidum. |
| Shao Y, Qiao L, Wu L, Sun X, Zhu D, Yang G, Zhang X, Mao X, Chen W, Liang W, Zhang Y, Zhang L. |
| Molecules. 2016 May 21;21(5). pii: E678. doi: 10.3390/molecules21050678. |
| Ganoderma lucidum total triterpenes attenuate DLA induced ascites and EAC induced solid tumours in Swiss albino mice. |
| Smina TP, Mathew J, Janardhanan KK. |
| Cell Mol Biol (Noisy-le-grand). 2016 Apr 30;62(5):55-9. |
| A supercritical-CO2 extract of Ganoderma lucidum spores inhibits cholangiocarcinoma cell migration by reversing the epithelial-mesenchymal transition. |
| Li L, Guo HJ, Zhu LY, Zheng L, Liu X. |
| Phytomedicine. 2016 May 15;23(5):491-7. doi: 10.1016/j.phymed.2016.02.019. Epub 2016 Mar 3. |
| Ergosterol peroxide activates Foxo3-mediated cell death signaling by inhibiting AKT and c-Myc in human hepatocellular carcinoma cells. |
| Li X, Wu Q, Bu M, Hu L, Du WW, Jiao C, Pan H, Sdiri M, Wu N, Xie Y, Yang BB. |
| Oncotarget. 2016 Jun 7;7(23):33948-59. doi: 10.18632/oncotarget.8608. |
| Ganoderma lucidum (Reishi mushroom) for cancer treatment. |
| Jin X, Ruiz Beguerie J, Sze DM, Chan GC. |
| Cochrane Database Syst Rev. 2016 Apr 5;4:CD007731. doi: 10.1002/14651858.CD007731.pub3. Review. |
| A proteomic analysis of mushroom polysaccharide-treated HepG2 cells. |
| Chai Y, Wang G, Fan L, Zhao M. |
| Sci Rep. 2016 Mar 29;6:23565. doi: 10.1038/srep23565. |
| Identification of Potential Anticancer Activities of Novel Ganoderma lucidum Extracts Using Gene Expression and Pathway Network Analysis. |
| Kao CH, Bishop KS, Xu Y, Han DY, Murray PM, Marlow GJ, Ferguson LR. |
| Genomics Insights. 2016 Feb 16;9:1-16. doi: 10.4137/GEI.S32477. eCollection 2016 Feb 16. |
| Inhibitor or promoter? The performance of polysaccharides from Ganoderma lucidum on human tumor cells with different p53 statuses. |
| Zhang J, Chen JM, Wang XX, Xia YM, Cui SW, Li J, Ding ZY. |
| Food Funct. 2016 Apr;7(4):1872-5. doi: 10.1039/c5fo01628b. |
| Recombinant FIP-gat, a Fungal Immunomodulatory Protein from Ganoderma atrum, Induces Growth Inhibition and Cell Death in Breast Cancer Cells. |
| Xu H, Kong YY, Chen X, Guo MY, Bai XH, Lu YJ, Li W, Zhou XW. |
| J Agric Food Chem. 2016 Apr 6;64(13):2690-8. doi: 10.1021/acs.jafc.6b00539. Epub 2016 Mar 24. |
| Ling Zhi-8 reduces lung cancer mobility and metastasis through disruption of focal adhesion and induction of MDM2-mediated Slug degradation. |
| Lin TY, Hsu HY. |
| Cancer Lett. 2016 Jun 1;375(2):340-8. doi: 10.1016/j.canlet.2016.03.018. Epub 2016 Mar 15. |
| Ganoderma lucidum Combined with the EGFR Tyrosine Kinase Inhibitor, Erlotinib Synergize to Reduce Inflammatory Breast Cancer Progression. |
| Suárez-Arroyo IJ, Rios-Fuller TJ, Feliz-Mosquea YR, Lacourt-Ventura M, Leal-Alviarez DJ, Maldonado-Martinez G, Cubano LA, Martínez-Montemayor MM. |
| J Cancer. 2016 Feb 5;7(5):500-11. doi: 10.7150/jca.13599. eCollection 2016 Feb 5. |
| Ganoderma lucidum total triterpenes prevent γ-radiation induced oxidative stress in Swiss albino mice in vivo. |
| Smina TP, Joseph J, Janardhanan KK. |
| Redox Rep. 2016 Nov;21(6):254-61. doi: 10.1080/13510002.2015.1126098. Epub 2016 Feb 5. |
| Neuroprotective and antioxidant lanostanoid triterpenes from the fruiting bodies of Ganoderma atrum. |
| Qiu J, Wang X, Song C. |
| Fitoterapia. 2016 Mar;109:75-9. doi: 10.1016/j.fitote.2015.12.008. Epub 2015 Dec 17. |
| Polysaccharides from Ganoderma lucidum attenuate microglia-mediated neuroinflammation and modulate microglial phagocytosis and behavioural response. |
| Cai Q, Li Y, Pei G. |
| J Neuroinflammation. 2017 Mar 24;14(1):63. doi: 10.1186/s12974-017-0839-0. |
| Screening and analysis of potential anti-tumor components from the stipe of Ganoderma sinense using high-performance liquid chromatography/time-of-flight mass spectrometry with multivariate statistical tool. |
| Chan KM, Yue GG, Li P, Wong EC, Lee JK, Kennelly EJ, Lau CB. |
| J Chromatogr A. 2017 Mar 3;1487:162-167. doi: 10.1016/j.chroma.2017.01.044. Epub 2017 Jan 22. |
| Structure and bioactivities of a polysaccharide isolated from Ganoderma lucidum in submerged fermentation. |
| Ai-Lati A, Liu S, Ji Z, Zhang H, Mao J. |
| Bioengineered. 2017 Jan 31:1-7. doi: 10.1080/21655979.2017.1283459. |
| Ganoderma lucidum total triterpenes induce apoptosis in MCF-7 cells and attenuate DMBA induced mammary and skin carcinomas in experimental animals. |
| Smina TP, Nitha B, Devasagayam TP, Janardhanan KK. |
| Mutat Res. 2017 Jan;813:45-51. doi: 10.1016/j.mrgentox.2016.11.010. Epub 2016 Dec 2. |
| Identification and Characterisation of a Novel Protein FIP-sch3 from Stachybotrys chartarum. |
| Li S, Zhao L, Xu W, Jiang Z, Kang J, Wang F, Xin F. |
| 10.1371/journal.pone.0168436. eCollection 2016 Dec 20. |
| Identification and Characterisation of a Novel Protein FIP-sch3 from Stachybotrys chartarum. |
| Li WJ, Tang XF, Shuai XX, Jiang CJ, Liu X, Wang LF, Yao YF, Nie SP, Xie MY. |
| J Agric Food Chem. 2017 Jan 18;65(2):348-357. doi: 10.1021/acs.jafc.6b04888. Epub 2017 Jan 3. |
| Antitumor effects and mechanisms of <i>Ganoderma</i> extracts and spores oil. |
| Chen C, Li P, Li Y, Yao G, Xu JH. |
| Oncol Lett. 2016 Nov;12(5):3571-3578. Epub 2016 Aug 29. |
| Improved Production and Antitumor Properties of Triterpene Acids from Submerged Culture of Ganoderma lingzhi. |
| Wang XL, Ding ZY, Liu GQ, Yang H, Zhou GY. |
| Molecules. 2016 Oct 20;21(10). pii: E1395. |
| Effects of the polysaccharides extracted from Ganoderma lucidum on chemotherapy-related fatigue in mice. |
| Ouyang MZ, Lin LZ, Lv WJ, Zuo Q, Lv Z, Guan JS, Wang ST, Sun LL, Chen HR, Xiao ZW. |
| Int J Biol Macromol. 2016 Oct;91:905-10. doi: 10.1016/j.ijbiomac.2016.04.084. Epub 2016 May 18. |
| Antimicrobial Properties and Cytotoxicity of Sulfated (1,3)-β-D-Glucan from the Mycelium of the Mushroom Ganoderma lucidum. |
| Wan-Mohtar WA, Young L, Abbott GM, Clements C, Harvey LM, McNeil B. |
| J Microbiol Biotechnol. 2016 Jun 28;26(6):999-1010. doi: 10.4014/jmb.1510.10018. |
| Resolution of Cutaneous Sarcoidosis Following Topical Application of Ganoderma lucidum (Reishi Mushroom). |
| Saylam Kurtipek G, Ataseven A, Kurtipek E, Kucukosmanoglu İ, Toksoz MR. |
| Dermatol Ther (Heidelb). 2016 Mar;6(1):105-9. doi: 10.1007/s13555-016-0099-4. Epub 2016 Feb 11. |
| Structural data and immunomodulatory properties of a water-soluble heteroglycan extracted from the mycelium of an Italian isolate of Ganoderma lucidum. |
| Carrieri R, Manco R, Sapio D, Iannaccone M, Fulgione A, Papaianni M, de Falco B, Grauso L, Tarantino P, Ianniello F, Lanzotti V, Lahoz E, Capparelli R. |
| Nat Prod Res. 2017 Jan 20:1-7. doi: 10.1080/14786419.2017.1278593. |
| Ganoderma lucidum polysaccharides protect fibroblasts against UVB-induced photoaging. |
| Zeng Q, Zhou F, Lei L, Chen J, Lu J, Zhou J, Cao K, Gao L, Xia F, Ding S, Huang L, Xiang H, Wang J, Xiao Y, Xiao R, Huang J. |
| Mol Med Rep. 2017 Jan;15(1):111-116. doi: 10.3892/mmr.2016.6026. Epub 2016 Dec 12. |
| Ganoderma atrum polysaccharide ameliorates ROS generation and apoptosis in spleen and thymus of immunosuppressed mice. |
| Li WJ, Li L, Zhen WY, Wang LF, Pan M, Lv JQ, Wang F, Yao YF, Nie SP, Xie MY. |
| Food Chem Toxicol. 2017 Jan;99:199-208. doi: 10.1016/j.fct.2016.11.033. Epub 2016 Nov 30. |
| Comparison of immunoregulatory effects of polysaccharides from three natural herbs and cellular uptake in dendritic cells. |
| Zhu N, Lv X, Wang Y, Li J, Liu Y, Lu W, Yang L, Zhao J, Wang F, Zhang LW. |
| Int J Biol Macromol. 2016 Dec;93(Pt A):940-951. doi: 10.1016/j.ijbiomac.2016.09.064. |
| Protective Effects of Sporoderm-Broken Spores of Ganderma lucidum on Growth Performance, Antioxidant Capacity and Immune Function of Broiler Chickens Exposed to Low Level of Aflatoxin B₁. |
| Liu T, Ma Q, Zhao L, Jia R, Zhang J, Ji C, Wang X. |
| Toxins (Basel). 2016 Sep 24;8(10). pii: E278. doi: 10.3390/toxins8100278. |
| Ganoderma lucidum polysaccharides encapsulated in liposome as an adjuvant to promote Th1-bias immune response. |
| Liu Z, Xing J, Zheng S, Bo R, Luo L, Huang Y, Niu Y, Li Z, Wang D, Hu Y, Liu J, Wu Y. |
| Carbohydr Polym. 2016 May 20;142:141-8. doi: 10.1016/j.carbpol.2016.01.021. Epub 2016 Jan 12. |
| Antioxidant Effects of Medicinal Mushrooms Agaricus brasiliensis and Ganoderma lucidum (Higher Basidiomycetes): Evidence from Animal Studies. |
| Yurkiv B, Wasser SP, Nevo E, Sybirna NO. |
| Int J Med Mushrooms. 2015;17(10):943-55. |
| Determination of nucleosides in Cordyceps sinensis and Ganoderma lucidum by high performance liquid chromatography method. |
| Khan MS, Parveen R, Mishra K, Tulsawani R, Ahmad S. |
| J Pharm Bioallied Sci. 2015 Oct-Dec;7(4):264-6. doi: 10.4103/0975-7406.168022. |
| Ganoderma: insights into anticancer effects. |
| Kladar NV, Gavarić NS, Božin BN. |
| Eur J Cancer Prev. 2016 Sep;25(5):462-71. doi: 10.1097/CEJ.0000000000000204. |
| The Effect of Agaricus brasiliensis and Ganoderma lucidum Medicinal Mushroom Administration on the L-arginine/Nitric Oxide System and Rat Leukocyte Apoptosis in Experimental Type 1 Diabetes Mellitus. |
| Yurkiv B, Wasser SP, Nevo E, Sybirna NO. |
| Int J Med Mushrooms. 2015;17(4):339-50. |
| Two new triterpenoids from fruiting bodies of fungus Ganoderma lucidum. |
| Zhao ZZ, Yin RH, Chen HP, Feng T, Li ZH, Dong ZJ, Cui BK, Liu JK |
| J Asian Nat Prod Res. 2015 Jan 29:1-6.[Epub ahead of print] |
| Ganoderma lucidum for Cancer Treatment: We Are Close but Still Not There. |
| Cheng S, Sliva D. |
| Integr Cancer Ther. 2015 Jan 27. pii: 1534735414568721. [Epub ahead of print] Review. |
| Cytokine production suppression by culture supernatant of B16F10 cells and amelioration by Ganoderma lucidum polysaccharides in activated lymphocytes. |
| Cheng S, Sliva D. |
| Integr Cancer Ther. 2015 Jan 27. pii: 1534735414568721. [Epub ahead of print] Review. |
| Khz (Fusion Product of Ganoderma lucidum and Polyporus umbellatus Mycelia) Induces Apoptosis in Human Colon Carcinoma HCT116 Cells, Accompanied by an Increase in Reactive Oxygen Species, Activation of Caspase 3, and Increased Intracellular Ca(2+). |
| Kim TH, Kim JS, Kim ZH, Huang RB, Chae YL, Wang RS. |
| J Med Food. 2015 Mar;18(3):332-6. doi: 10.1089/jmf.2013.3135. Epub 2014 Dec 9. |
| Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities. |
| Ferreira IC, Heleno SA, Reis FS, Stojkovic D, Queiroz MJ, Vasconcelos MH, Sokovic M. |
| Phytochemistry. 2014 Nov 5. pii: S0031-9422(14)00415-4. doi: 10.1016/j.phytochem.2014.10.011. [Epub ahead of print] Review. |
| Ganoderma lucidum inhibits proliferation of human ovarian cancer cells by suppressing VEGF expression and up-regulating the expression of connexin 43. |
| Dai S, Liu J, Sun X, Wang N. |
| BMC Complement Altern Med. 2014 Nov 5;14:434. doi: 10.1186/1472-6882-14-434. |
| A comprehensive review of the structure elucidation and biological activity of triterpenoids from Ganoderma spp. |
| Xia Q, Zhang H, Sun X, Zhao H, Wu L, Zhu D, Yang G, Shao Y, Zhang X, Mao X, Zhang L, She G. |
| Molecules. 2014 Oct 30;19(11):17478-535. doi: 10.3390/molecules191117478. |
| Fungal beta glucan protects radiation induced DNA damage in human lymphocytes. |
| Pillai TG, Maurya DK, Salvi VP, Janardhanan KK, Nair CK. |
| Ann Transl Med. 2014 Feb;2(2):13. doi: 10.3978/j.issn.2305-5839.2014.02.02. |
| Wound healing activity of an aqueous extract of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes). |
| Gupta A, Kirar V, Keshri GK, Gola S, Yadav A, Negi PS, Misra K. |
| Int J Med Mushrooms. 2014;16(4):345-54. |
| CARI III inhibits tumor growth in a melanoma-bearing mouse model through induction of G0/G1 cell cycle arrest. |
| Park HJ. |
| Molecules. 2014 Sep 12;19(9):14383-95. doi: 10.3390/molecules190914383. |
| A comparative study on immunomodulatory activity of polysaccharides from two official species of Ganoderma (Lingzhi). |
| Meng LZ, Xie J, Lv GP, Hu DJ, Zhao J, Duan JA, Li SP. |
| Nutr Cancer. 2014;66(7):1124-31. doi: 10.1080/01635581.2014.948215. Epub 2014 Sep 10. |
| Activation of antitumor immune responses by Ganoderma formosanum polysaccharides in tumor-bearing mice. |
| Wang CL, Lu CY, Hsueh YC, Liu WH, Chen CJ. |
| Appl Microbiol Biotechnol. 2014 Nov;98(22):9389-98. doi: 10.1007/s00253-014-6027-6. Epub 2014 Sep 2. |
| Bioactive proteins and peptides isolated from Chinese medicines with pharmaceutical potential. |
| Wong KL, Wong RN, Zhang L, Liu WK, Ng TB, Shaw PC, Kwok PC, Lai YM, Zhang ZJ, Zhang Y, Tong Y, Cheung HP, Lu J, Sze SC. |
| Chin Med. 2014 Jul 19;9:19. doi: 10.1186/1749-8546-9-19. eCollection 2014. Review. |
| Khz-cp (crude polysaccharide extract obtained from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating P38 and NADPH oxidase-dependent generation of reactive oxygen species in SNU-1 cells. |
| Wong KL, Wong RN, Zhang L, Liu WK, Ng TB, Shaw PC, Kwok PC, Lai YM, Zhang ZJ, Zhang Y, Tong Y, Cheung HP, Lu J, Sze SC. |
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| A chemically sulfated polysaccharide derived from Ganoderma lucidum induces mitochondrial-mediated apoptosis in human osteosarcoma MG63 cells. |
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| A novel polysaccharide from Ganoderma atrum exerts antitumor activity by activating mitochondria-mediated apoptotic pathway and boosting the immune system. |
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| Cytokine production suppression by culture supernatant of B16F10 cells and amelioration by Ganoderma lucidum polysaccharides in activated lymphocytes. |
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| Exopolysaccharide from Ganoderma applanatum as a promising bioactive compound with cytostatic and antibacterial properties. |
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| The Effect of Mushroom Beta-Glucans from Solid Culture of Ganoderma lucidum on Inhibition of the Primary Tumor Metastasis. |
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| Effects of Selenium-Enriched Protein from Ganoderma lucidum on the Levels of IL-1 β and TNF- α , Oxidative Stress, and NF- κ B Activation in Ovalbumin-Induced Asthmatic Mice. |
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| Acetylation and carboxymethylation of the polysaccharide from Ganoderma atrum and their antioxidant and immunomodulating activities. |
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| Immunomodulatory of selenium nano-particles decorated by sulfated Ganoderma lucidum polysaccharides. |
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| Anti-inflammatory and hepatoprotective effects of Ganoderma lucidum polysaccharides on carbon tetrachloride-induced hepatocyte damage in common carp (Cyprinus carpio L.). |
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| Ganoderma formosanum polysaccharides attenuate Th2 inflammation and airway hyperresponsiveness in a murine model of allergic asthma. |
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| Suppression of inflammatory and allergic responses by pharmacologically potent fungus Ganoderma lucidum. |
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