Reference Literature
Covid-19
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Inflammation Covid-19    
       
 
The Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Can Combat Cytokine Storm and Other COVID-19 Related Pathologies: A Review.
Rowaiye AB, Ogugua AJ, Bur D, Wood T, Labbo Z, Chukwu C, Afolabi FJ, Nwonu EJ, Agbalalah T.
Int J Med Mushrooms. 2023;25(5):1-15. doi: 10.1615/IntJMedMushrooms.2023048109.
 
GMI, a fungal immunomodulatory protein, ameliorates SARS-CoV-2 envelope protein-induced inflammation in macrophages via inhibition of MAPK pathway.
Lin ZH, Yeh H, Lo HC, Hua WJ, Ni MY, Wang LK, Chang TT, Yang MH, Lin TY.
Int J Biol Macromol. 2023 Jun 30;241:124648. doi: 10.1016/j.ijbiomac.2023.124648. Epub 2023 Apr 28.
 
Ganoderma microsporum immunomodulatory protein acts as a multifunctional broad-spectrum antiviral against SARS-CoV-2 by interfering virus binding to the host cells and spike-mediated cell fusion.
Ho HPT, Vo DNK, Lin TY, Hung JN, Chiu YH, Tsai MH.
Biomed Pharmacother. 2022 Nov;155:113766. doi: 10.1016/j.biopha.2022.113766. Epub 2022 Sep 28.
 
Lucidenic acid A inhibits the binding of hACE2 receptor with spike protein to prevent SARS-CoV-2 invasion.
Xu J, Yang W, Pan Y, Xu H, He L, Zheng B, Xie Y, Wu X.
Food Chem Toxicol. 2022 Nov;169:113438. doi: 10.1016/j.fct.2022.113438. Epub 2022 Sep 28.
 
GMI, a protein from Ganoderma microsporum, induces ACE2 degradation to alleviate infection of SARS-CoV-2 Spike-pseudotyped virus.
Yeh H, Vo DNK, Lin ZH, Ho HPT, Hua WJ, Qiu WL, Tsai MH, Lin TY.
Phytomedicine. 2022 Aug;103:154215. doi: 10.1016/j.phymed.2022.154215. Epub 2022 May 28.

Rationalization of Mushroom-Based Preventive and Therapeutic Approaches to COVID-19: Review.
Rahman MA, Rahman MS, Bashir NMB, Mia R, Hossain A, Saha SK, Kakon AJ, Sarker NC.
Int J Med Mushrooms. 2021;23(5):1-11. doi: 10.1615/IntJMedMushrooms.2021038285.
 
Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection
Jia-Tsrong Jan 1, Ting-Jen Rachel Cheng 1, Yu-Pu Juang 2, Hsiu-Hua Ma 1, Ying-Ta Wu 1, Wen-Bin Yang 1, Cheng-Wei Cheng 1, Xiaorui Chen 1, Ting-Hung Chou 3, Jiun-Jie Shie 3, Wei-Chieh Cheng 1, Rong-Jie Chein 3, Shi-Shan Mao 1, Pi-Hui Liang 4 2, Che Ma 4, Shang-Cheng Hung 4, Chi-Huey Wong 4
Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e2021579118. doi: 10.1073/pnas.2021579118.
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