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Inflammation
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| Triterpenoids from Ganoderma cochlear against inflammation and renal fibrosis. |
| Zhang JB, Li SH, Li ZY, Yan YM, Cheng YX. |
| Fitoterapia. 2025 Apr 13:106543. doi: 10.1016/j.fitote.2025.106543. Online ahead of print. |
| Ganoderma lucidum polysaccharide alleviates cognitive dysfunction by inhibiting neuroinflammation via NLRP3/NF-kappaB signaling pathway. |
| Jiang Y, Wang Z, Wang W, Liu Y, Meng Y, Wang Y, Fan M, Cai C. |
| J Ethnopharmacol. 2025 Feb 10;338(Pt 2):119065. doi: 10.1016/j.jep.2024.119065. Epub 2024 Nov 8. |
| Ganoderma Lucidum polysaccharide peptide (GL-PP2): A potential therapeutic agent against sepsis-induced organ injury by modulating Nrf2/NF-kappaB pathways. |
| Yang T, Fang H, Lin D, Yang S, Luo H, Wang L, Yang B. |
| Int J Biol Macromol. 2025 Jan;285:138378. doi: 10.1016/j.ijbiomac.2024.138378. Epub 2024 Dec 4. |
| Potentials of Natural Antioxidants in Reducing Inflammation and Oxidative Stress in Chronic Kidney Disease. |
| Lee OYA, Wong ANN, Ho CY, Tse KW, Chan AZ, Leung GP, Kwan YW, Yeung MHY. |
| Antioxidants (Basel). 2024 Jun 20;13(6):751. doi: 10.3390/antiox13060751. |
| COP-22 Alleviates D-Galactose-Induced Brain Aging by Attenuating Oxidative Stress, Inflammation, and Apoptosis in Mice. |
| Ma Y, Wang X, Li X, Chen X, Teng Z, Wang X, Yang J, Liu G. |
| Mol Neurobiol. 2024 Sep;61(9):6708-6720. doi: 10.1007/s12035-024-03976-1. Epub 2024 Feb 12. |
| Ganoderma lucidum triterpenoids investigating their role in medicinal applications and genomic protection. |
| Raza SHA, Zhong R, Li X, Pant SD, Shen X, BinMowyna MN, Luo L, Lei H. |
| J Pharm Pharmacol. 2024 Dec 2;76(12):1535-1551. doi: 10.1093/jpp/rgae133. |
| The Efficacy & Molecular Mechanisms of a Terpenoid Compound Ganoderic Acid C1 on Corticosteroid-Resistant Neutrophilic Airway Inflammation: In vivo and in vitro Validation. |
| Wang ZZ, Li H, Maskey AR, Srivastava K, Liu C, Yang N, Xie T, Fu Z, Li J, Liu X, Sampson HA, Li XM. |
| J Inflamm Res. 2024 Apr 25;17:2547-2561. doi: 10.2147/JIR.S433430. eCollection 2024. |
| Identification of sedative-hypnotic compounds shared by five medicinal Polyporales mushrooms using UPLC-Q-TOF-MS/MS-based untargeted metabolomics. |
| Chen W, Yu JW, Deng YY, Wong LY, Wang C, Liang YL, Leung YT, Tian JY, Wu Y, Leung KS, Hu J, Chen WH, Dou X, Fu XQ, Chen YJ, Yu ZL. |
| Phytomedicine. 2024 Jun;128:155355. doi: 10.1016/j.phymed.2024.155355. Epub 2024 Jan 12. |
| Acidic polysaccharide from Ganoderma tsugae: Structural characterization and antiatherosclerotic related to macrophage polarization. |
| Zhang X, Liu S, Kong F, Shu L, Li Y, Wang D, Li L. |
| Food Res Int. 2025 Feb;203:115913. doi: 10.1016/j.foodres.2025.115913. Epub 2025 Feb 3. |
| Ganoderma Microsporum Immunomodulatory Protein Alleviates Inflammaging and Oxidative Stress in Diabetes-Associated Periodontitis via Nrf2 Signaling Activation: An In Vitro Study. |
| Su NY, Ng MY, Liao HY, Liao YW, Wu M, Chao SC, Yu CC, Chang YC. |
| Antioxidants (Basel). 2024 Jul 8;13(7):817. doi: 10.3390/antiox13070817. |
| Ganoderma lucidum Polysaccharide/carboxymethyl Chitosan Hydrogels Modulate Macrophage Polarization for Wound Healing. |
| Zou Y, Yang Y, Pei J, Sun P, Wang Y. |
| Biomacromolecules. 2025 Apr 14;26(4):2675-2689. doi: 10.1021/acs.biomac.5c00112. Epub 2025 Mar 28. |
| Alcoholic Extracts from the Ganoderma Lucidum Fermentation Product Alleviated Ethanol-Induced Liver Injury, Gut Leakiness, and Gut Dysbiosis in Mice. |
| Zhao Z, Ma X, Li M, Chen G, Qi L, Song S, Li Z, Yan C. |
| Plant Foods Hum Nutr. 2024 Dec 5;80(1):2. doi: 10.1007/s11130-024-01271-x. |
| Extraction Optimization and Bioactivity of Polysaccharides from Ganoderma leucocontextum Spores. |
| Peng S, Ou Y, Zhang Y, Yao H, Chen WH. |
| Pharmaceuticals (Basel). 2025 Feb 11;18(2):241. doi: 10.3390/ph18020241. |
| A glucan from Ganoderma lucidum: Structural characterization and the anti-inflammatory effect on Parkinson's disease via regulating dysfunctions of intestinal microecology and inhibiting TLR4/MyD88/NF-kappaB signaling pathway. |
| Chen L, Ling Y, Sun J, Zhou S, Xiao Y, Zou X, Yang X, Zhang Y. |
| J Ethnopharmacol. 2025 Mar 13;343:119446. doi: 10.1016/j.jep.2025.119446. Epub 2025 Feb 4. |
| High molecular weight polysaccharides from Ganoderma lucidum attenuates inflammatory responses, gut microbiota, and liver metabolomic in lipopolysaccharide-induced liver injury mice. |
| Guo W, Liu W, Liang P, Ni L, Lv X, Fan J, Shi F. |
| Int J Biol Macromol. 2025 Jan;287:138400. doi: 10.1016/j.ijbiomac.2024.138400. Epub 2024 Dec 8. |
| Integrating transcriptomics, metabolomics, and network pharmacology to investigate multi-target effects of sporoderm-broken spores of Ganoderma lucidum on improving HFD-induced diabetic nephropathy rats. |
| Hu L, Yu L, Cao Z, Wang Y, Zhu C, Li Y, Yin J, Ma Z, He X, Zhang Y, Huang W, Guan Y, Chen Y, Li X, Chen X. |
| J Pharm Anal. 2024 Dec;14(12):101105. doi: 10.1016/j.jpha.2024.101105. Epub 2024 Sep 19. |
| Ganoderma lucidum spore oil attenuates acute liver injury by modulating lipid metabolism and gut microbiota. |
| Liu J, Chen Y, Cen Z, Hong M, Zhang B, Luo X, Wang L, Li S, Xiao X, Long Q. |
| J Pharm Biomed Anal. 2025 Apr 15;256:116674. doi: 10.1016/j.jpba.2025.116674. Epub 2025 Jan 16. |
| Mushrooms in modern cosmetics: unlocking anti-aging, antioxidant, and therapeutic potential. |
| Rukhsar S, Usman M, Yousaf N, Murtaza G, Manzoor MA, Azam M. |
| Arch Dermatol Res. 2025 Mar 9;317(1):542. doi: 10.1007/s00403-025-04048-7. |
| Ganoderma lucidum Extract Modulates Gene Expression Profiles Associated with Antioxidant Defense, Cytoprotection, and Senescence in Human Dermal Fibroblasts: Investigation of Quantitative Gene Expression by qPCR. |
| Kühnel H, Seiler M, Feldhofer B, Ebrahimian A, Maurer M. |
| Curr Issues Mol Biol. 2025 Feb 18;47(2):130. doi: 10.3390/cimb47020130. |
| Use of Herbal Drugs in Cardiovascular Disease- A Review. |
| Kaur A, Kumar R. |
| Curr Cardiol Rev. 2025;21(1):e1573403X323724. doi: 10.2174/011573403X323724240830075719. |
| Ganoderma lucidum polysaccharides reduce the severity of acute liver injury by improving the diversity and function of the gut microbiota. |
| Zhang XT, Yang Y, Ji C, Fu Y, Pu X, Xu G. |
| Heliyon. 2024 Aug 2;10(15):e35559. doi: 10.1016/j.heliyon.2024.e35559. eCollection 2024 Aug 15. |
| Structural characteristics of a heteropolysaccharide from Ganoderma lucidum and its protective effect against Alzheimer's disease via modulating the microbiota-gut-metabolomics. |
| Chen L, Wang X, Sun J, Xue J, Yang X, Zhang Y. |
| Int J Biol Macromol. 2025 Mar;297:139863. doi: 10.1016/j.ijbiomac.2025.139863. Epub 2025 Jan 13. |
| Investigating the therapeutic potential of Ganoderma lucidum in treating optic nerve atrophy through network pharmacology and experimental validation. |
| Zhilin L, Haobo F, Juan W, AiRui X, XiaoDong L, Yuan Y, Junguo D. |
| Biochem Biophys Res Commun. 2025 May 26;760:151702. doi: 10.1016/j.bbrc.2025.151702. Epub 2025 Mar 26. |
| Modification of Ganoderma lucidum spore shells into probiotic carriers: selective loading and colonic delivery of Lacticaseibacillus rhamnosus and effective therapy of inflammatory bowel disease. |
| Liao N, Wang J, Liu G, Li Y, Xu F, Xu K, Shi D, Shao D, Jiang C, Shi J. |
| Food Funct. 2025 Feb 3;16(3):908-927. doi: 10.1039/d4fo04523h. |
| Systems Pharmacology-based Drug Discovery and Active Mechanism of Ganoderma lucidum Triterpenoids for Type 2 Diabetes Mellitus by Integrating Network Pharmacology and Molecular Docking. |
| Shi J, Chen J, Cheng C, Li W, Li M, Ye S, Liu Z, Ding Y. |
| Curr Pharm Des. 2025 Feb 13. doi: 10.2174/0113816128365423250126035306. Online ahead of print. |
| Unveiling the anticancer potential and toxicity of Ganoderma applanatum wild mushroom derived bioactive compounds: An in vitro, in vivo and in silico evaluation. |
| Rijia A, Krishnamoorthi R, Mahalingam PU, Kaviyadharshini M, Rajeswari M, Kumar KKS, Rasmi M, Chung YK, Fang JY. |
| Bioorg Chem. 2025 Mar;156:108233. doi: 10.1016/j.bioorg.2025.108233. Epub 2025 Jan 31. |
| Anti-inflammatory effects of para-quinone methide derivatives on ulcerative colitis. |
| Qiu Y, Li X, Zhang X, Wang X, Wang X, Yang J, Liu G. |
| Front Pharmacol. 2024 Oct 29;15:1474678. doi: 10.3389/fphar.2024.1474678. eCollection 2024. |
| Evaluation of in vitro pharmacological activities of medicinal mushrooms in the context of dry eye disease. |
| Areesanan A, Wasilewicz A, Nicolay S, Grienke U, Zimmermann-Klemd AM, Rollinger JM, Gründemann C. |
| Front Pharmacol. 2025 Mar 5;16:1557359. doi: 10.3389/fphar.2025.1557359. eCollection 2025. |
| Ganoderma atrum polysaccharide inhibits ROS/NLRP3/pyroptosis axis by fixing mitochondrial dynamics disorder in PD-1 inhibitors-induced carditis of Lewis lung carcinoma mice. |
| Mu XY, Chen SB, Yang SY, Wang WS, Zhou HM, Wang YX, Chen XY, Peng XP, Li WJ. |
| Int J Biol Macromol. 2025 Apr 15:143163. doi: 10.1016/j.ijbiomac.2025.143163. Online ahead of print. |
| Ganoderic Acid A Prevented Osteoporosis by Modulating the PIK3CA/p-Akt/TWIST1 Signaling Pathway. |
| Zhao J, Fan Y, Li H, Wang C, Fan S, Sun H, Liu M. |
| Food Sci Nutr. 2025 Apr 14;13(4):e70177. doi: 10.1002/fsn3.70177. eCollection 2025 Apr. |
| Identification of sedative-hypnotic compounds shared by five medicinal Polyporales mushrooms using UPLC-Q-TOF-MS/MS-based untargeted metabolomics. |
| Chen W, Yu JW, Deng YY, Wong LY, Wang C, Liang YL, Leung YT, Tian JY, Wu Y, Leung KS, Hu J, Chen WH, Dou X, Fu XQ, Chen YJ, Yu ZL. |
| Phytomedicine. 2024 Jan 12;128:155355. doi: 10.1016/j.phymed.2024.155355. Online ahead of print. |
| Anti-Inflammatory Effects of Chamaecyparis obtusa (Siebold & Zucc.) Endl. Leaf Extract Fermented by Ganoderma applanatum Mycelia. |
| Kim CH, Kwon YJ, Jang YA. |
| Pharmaceutics. 2024 Mar 5;16(3):365. doi: 10.3390/pharmaceutics16030365. |
| Ganoderic acids alleviate atherosclerosis by inhibiting macrophage M1 polarization via TLR4/MyD88/NF-κB signaling pathway. |
| Quan YZ, Ma A, Ren CQ, An YP, Qiao PS, Gao C, Zhang YK, Li XW, Lin SM, Li NN, Chen DL, Pan Y, Zhou H, Lin DM, Lin SQ, Li M, Yang BX. |
| Atherosclerosis. 2024 Feb 8;391:117478. doi: 10.1016/j.atherosclerosis.2024.117478. Online ahead of print. |
| COP-22 Alleviates D-Galactose-Induced Brain Aging by Attenuating Oxidative Stress, Inflammation, and Apoptosis in Mice. |
| Ma Y, Wang X, Li X, Chen X, Teng Z, Wang X, Yang J, Liu G. |
| Mol Neurobiol. 2024 Feb 12. doi: 10.1007/s12035-024-03976-1. Online ahead of print. |
| Evaluation of the amelioration effect of Ganoderma formosanum extract on delaying PM2.5 damage to lung macrophages. |
| Hou CY, Hsieh CC, Hung YC, Hsu CC, Hsieh CW, Yu SH, Cheng KC. |
| Mol Nutr Food Res. 2024 Mar;68(5):e2300667. doi: 10.1002/mnfr.202300667. Epub 2024 Jan 28. |
| The protective effect of PL 1-3 on D-galactose-induced aging mice. |
| Li P, Ma Y, Wang X, Li X, Wang X, Yang J, Liu G. |
| Front Pharmacol. 2024 Jan 3;14:1304801. doi: 10.3389/fphar.2023.1304801. eCollection 2023. |
| Discovery of a 4-Hydroxy-3'-Trifluoromethoxy-Substituted Resveratrol Derivative as an Anti-Aging Agent. |
| Liang Y, Chen X, Teng Z, Wang X, Yang J, Liu G. |
| Molecules. 2023 Dec 22;29(1):86. doi: 10.3390/molecules29010086. |
| Ganoderic acid A slows osteoarthritis progression by attenuating endoplasmic reticulum stress and blocking NF-Κb pathway. |
| Liu Y, Zhou C, Tan J, Wu T, Pan C, Liu J, Cheng X. |
| Chem Biol Drug Des. 2024 Jan;103(1):e14382. doi: 10.1111/cbdd.14382. Epub 2023 Nov 20. |
| Traditional Chinese Medicine in Osteoporosis Intervention and the Related Regulatory Mechanism of Gut Microbiome. |
| Li K, Jiang Y, Wang N, Lai L, Xu S, Xia T, Yue X, Xin H. |
| Am J Chin Med. 2023;51(8):1957-1981. doi: 10.1142/S0192415X23500866. Epub 2023 Oct 27. |
| Therapeutic potential of Ganoderma lucidum polysaccharide peptide in Doxorubicin-induced nephropathy: modulation of renin-angiotensin system and proteinuria. |
| Fang H, Lin D, Li X, Wang L, Yang T. |
| Front Pharmacol. 2023 Sep 29;14:1287908. doi: 10.3389/fphar.2023.1287908. eCollection 2023. |
| Expression of concern: The protective effects of the Ganoderma atrum polysaccharide against acrylamide-induced inflammation and oxidative damage in rats. |
| Jiang G, Lei A, Chen Y, Yu Q, Xie J, Yang Y, Yuan T, Su D. |
| Food Funct. 2023 Sep 19;14(18):8663. doi: 10.1039/d3fo90079g. |
| Natural Products in Renal-Associated Drug Discovery. |
| Wruck W, Genfi AKA, Adjaye J. |
| Antioxidants (Basel). 2023 Aug 11;12(8):1599. doi: 10.3390/antiox12081599. |
| Preclinical pharmacokinetics-related pharmacological effects of orally administered polysaccharides from traditional Chinese medicines: A review. |
| Ye D, Zhao Q, Ding D, Ma BL. |
| Int J Biol Macromol. 2023 Dec 1;252:126484. doi: 10.1016/j.ijbiomac.2023.126484. Epub 2023 Aug 23. |
| Ganoderma lucidum polysaccharide peptide (GLPP) attenuates rheumatic arthritis in rats through inactivating NF-kappaB and MAPK signaling pathways. |
| Meng M, Wang L, Yao Y, Lin D, Wang C, Yao J, Sun H, Liu M. |
| Phytomedicine. 2023 Oct;119:155010. doi: 10.1016/j.phymed.2023.155010. Epub 2023 Aug 2. |
| Lanostane triterpenoids with anti-proliferative and anti-inflammatory activities from medicinal mushroom Ganoderma lingzhi. |
| Zhao ZZ, Ji BY, Wang ZZ, Si YY, Sun YJ, Chen H, Feng WS, Zheng XK, Liu JK. |
| Phytochemistry. 2023 Sep;213:113791. doi: 10.1016/j.phytochem.2023.113791. Epub 2023 Jul 14. |
| Combined Ganoderma lucidum polysaccharide and ciprofloxacin therapy alleviates Salmonella enterica infection, protects the intestinal barrier, and regulates gut microbiota. |
| Li M, Yu L, Zhai Q, Chu C, Wang S, Zhao J, Zhang H, Tian F, Chen W. |
| Food Funct. 2023 Jul 31;14(15):6896-6913. doi: 10.1039/d3fo00625e. |
| Amelioration of CCl(4)-induced oxidative stress and hepatotoxicity by Ganoderma lucidum in long evans rats. |
| Johra FT, Hossain S, Jain P, Bristy AT, Emran T, Ahmed R, Sharker SM, Bepari AK, Reza HM. |
| Sci Rep. 2023 Jun 19;13(1):9909. doi: 10.1038/s41598-023-35228-y. |
| Ganoderma lucidum polysaccharide peptides GL-PPSQ(2) alleviate intestinal ischemia-reperfusion injury via inhibiting cytotoxic neutrophil extracellular traps. |
| Lin D, Zhang Y, Wang S, Zhang H, Gao C, Lu F, Li M, Chen D, Lin Z, Yang B. |
| Int J Biol Macromol. 2023 Jul 31;244:125370. doi: 10.1016/j.ijbiomac.2023.125370. Epub 2023 Jun 16. |
| Polysaccharide of Ganoderma lucidum Ameliorates Cachectic Myopathy Induced by the Combination Cisplatin plus Docetaxel in Mice. |
| Wu SY, Ou CC, Lee ML, Hsin IL, Kang YT, Jan MS, Ko JL. |
| Microbiol Spectr. 2023 Jun 15;11(3):e0313022. doi: 10.1128/spectrum.03130-22. Epub 2023 May 22. |
| The Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Can Combat Cytokine Storm and Other COVID-19 Related Pathologies: A Review. |
| Rowaiye AB, Ogugua AJ, Bur D, Wood T, Labbo Z, Chukwu C, Afolabi FJ, Nwonu EJ, Agbalalah T. |
| Int J Med Mushrooms. 2023;25(5):1-15. doi: 10.1615/IntJMedMushrooms.2023048109. |
| Edible and medicinal mushrooms (Pleurotus ostreatus, Ustilago maydis, Ganoderma lucidum) reduce endoplasmic reticulum stress and inflammation in adipose tissue of obese Wistar rats fed with a high fat plus saccharose diet. |
| González-Ibáñez L, Meneses ME, Sánchez-Tapia M, Pérez-Luna D, Torres N, Torre-Villalvazo I, Bonilla M, Petlacalco B, Castillo I, López-Barradas A, Macías A, Tovar AR, Martínez-Carrera D. |
| Food Funct. 2023 Jun 6;14(11):5048-5061. doi: 10.1039/d3fo00089c. |
| GMI, a fungal immunomodulatory protein, ameliorates SARS-CoV-2 envelope protein-induced inflammation in macrophages via inhibition of MAPK pathway. |
| Lin ZH, Yeh H, Lo HC, Hua WJ, Ni MY, Wang LK, Chang TT, Yang MH, Lin TY. |
| Int J Biol Macromol. 2023 Jun 30;241:124648. doi: 10.1016/j.ijbiomac.2023.124648. Epub 2023 Apr 28. |
| Neuroprotective, neurogenic, and anticholinergic evidence of Ganoderma lucidum cognitive effects: Crucial knowledge is still lacking. |
| Luz DA, Pinheiro AM, Fontes-Júnior EA, Maia CSF. |
| Med Res Rev. 2023 Sep;43(5):1504-1536. doi: 10.1002/med.21957. Epub 2023 Apr 13. |
| Effects of Mexican Ganoderma lucidum extracts on liver, kidney, and the gut microbiota of Wistar rats: A repeated dose oral toxicity study. |
| Meneses ME, Martínez-Carrera D, González-Ibáñez L, Torres N, Sánchez-Tapia M, Márquez-Mota CC, Rendón G, Mitzi V, Morales A, Tello-Salgado I, Tovar AR. |
| PLoS One. 2023 Apr 6;18(4):e0283605. doi: 10.1371/journal.pone.0283605. eCollection 2023. |
| Effect of Supplemental Antioxidant-Based Therapy on the Oxidative Stress Level in COVID-19 Patients. |
| Zendelovska D, Atanasovska E, Spasovska K, Kirijas M, Kapsarov K, Jakimovski D, Petrushevska M. |
| Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2023 Mar 29;44(1):7-16. doi: 10.2478/prilozi-2023-0002. Print 2023 Mar 1. |
| Potential Anti-Rheumatoid Arthritis Activities and Mechanisms of Ganoderma lucidum Polysaccharides. |
| Meng M, Yao J, Zhang Y, Sun H, Liu M. |
| Molecules. 2023 Mar 8;28(6):2483. doi: 10.3390/molecules28062483. |
| Ganoderma lucidum polysaccharides ameliorates D-galactose-induced aging salivary secretion disorders by upregulating the rhythm and aquaporins. |
| Wu M, Huang B, Hu L, Zhang T, Zhang B, Zhao X, Lu R, Xiong W, Zhang S, Li J, Chen D, Yang B, Li G, Ran J. |
| Exp Gerontol. 2023 May;175:112147. doi: 10.1016/j.exger.2023.112147. Epub 2023 Mar 28. |
| GLSP and GLSP-derived triterpenes attenuate atherosclerosis and aortic calcification by stimulating ABCA1/G1-mediated macrophage cholesterol efflux and inactivating RUNX2-mediated VSMC osteogenesis. |
| Zheng G, Zhao Y, Li Z, Hua Y, Zhang J, Miao Y, Guo Y, Li L, Shi J, Dong Z, Yang S, Fan G, Ma C. |
| Theranostics. 2023 Feb 21;13(4):1325-1341. doi: 10.7150/thno.80250. eCollection 2023. |
| The anti-hepatocellular carcinoma effects of polysaccharides from Ganoderma lucidum by regulating macrophage polarization via the MAPK/NF-kappaB signaling pathway. |
| Li GL, Tang JF, Tan WL, Zhang T, Zeng D, Zhao S, Ran JH, Li J, Wang YP, Chen DL. |
| Food Funct. 2023 Apr 3;14(7):3155-3168. doi: 10.1039/d2fo02191a. |
| Ganoderma lucidum polysaccharides improve lipid metabolism against high-fat diet-induced dyslipidemia. |
| Wang W, Zhang Y, Wang Z, Zhang J, Jia L. |
| J Ethnopharmacol. 2023 Jun 12;309:116321. doi: 10.1016/j.jep.2023.116321. Epub 2023 Mar 1. |
| Inhibitory effect of polysaccharides extracted from Changbai Mountain Ganoderma lucidum on periodontal inflammation. |
| Chen Z, Qin W, Lin H, Liu Y, Tian Y, Zhao X, Ding T, Wang Y, Mao T, Li J, Shen Y. |
| Heliyon. 2023 Jan 28;9(2):e13205. doi: 10.1016/j.heliyon.2023.e13205. eCollection 2023 Feb. |
| Ganoderma lucidum polysaccharide inhibits HSC activation and liver fibrosis via targeting inflammation, apoptosis, cell cycle, and ECM-receptor interaction mediated by TGF-beta/Smad signaling. |
| Chen C, Chen J, Wang Y, Fang L, Guo C, Sang T, Peng H, Zhao Q, Chen S, Lin X, Wang X. |
| Phytomedicine. 2023 Feb;110:154626. doi: 10.1016/j.phymed.2022.154626. Epub 2022 Dec 24. |
| Ganoderma lucidum Ethanol Extraction Promotes Dextran Sulphate Sodium Induced Colitis Recovery and Modulation in Microbiota. |
| Li M, Yu L, Zhai Q, Liu B, Zhao J, Chen W, Tian F. |
| Foods. 2022 Dec 13;11(24):4023. doi: 10.3390/foods11244023. |
| Combination of Spirulina platensis, Ganoderma lucidum and Moringa oleifera Improves Cardiac Functions and Reduces Pro-Inflammatory Biomarkers in Preclinical Models of Short-Term Doxorubicin-Mediated Cardiotoxicity: New Frontiers in Cardioncology? |
| Quagliariello V, Basilicata MG, Pepe G, De Anseris R, Di Mauro A, Scognamiglio G, Palma G, Vestuto V, Buccolo S, Luciano A, Barbieri M, Bruzzese F, Maurea C, Pumpo R, Ostacolo C, Campiglia P, Berretta M, Maurea N. |
| J Cardiovasc Dev Dis. 2022 Nov 28;9(12):423. doi: 10.3390/jcdd9120423. |
| The protective effect of Ganoderma atrum polysaccharide on intestinal barrier function damage induced by acrylamide in mice through TLR4/MyD88/NF-kappaB based on the iTRAQ analysis. |
| Su D, Lei A, Nie C, Chen Y. |
| Food Chem Toxicol. 2023 Jan;171:113548. doi: 10.1016/j.fct.2022.113548. Epub 2022 Dec 9. |
| Inhibitory effects of Ganoderma lucidum spore oil on rheumatoid arthritis in a collagen-induced arthritis mouse model. |
| Heo Y, Kim M, Suminda GGD, Min Y, Zhao Y, Ghosh M, Son YO. |
| Biomed Pharmacother. 2023 Jan;157:114067. doi: 10.1016/j.biopha.2022.114067. Epub 2022 Dec 5. |
| Lucidumol A, Purified Directly from Ganoderma lucidum, Exhibits Anticancer Effect and Cellular Inflammatory Response in Colorectal Cancer. |
| Shin MJ, Chae HJ, Lee JW, Koo MH, Kim HJ, Seo JB, yanIllia S, Park SH, Lo HE, Kim SH, Youn UJ, Jeon YJ, Suh SS. |
| Evid Based Complement Alternat Med. 2022 Nov 8;2022:7404493. doi: 10.1155/2022/7404493. eCollection 2022. |
| Ganoderma lucidum polysaccharides ameliorate lipopolysaccharide-induced acute pneumonia via inhibiting NRP1-mediated inflammation. |
| Zhang X, Wu D, Tian Y, Chen X, Lan J, Wei F, Li Y, Luo Y, Sun X. |
| Pharm Biol. 2022 Dec;60(1):2201-2209. doi: 10.1080/13880209.2022.2142615. |
| Sporoderm-broken spore powder of Ganoderma lucidum ameliorate obesity and inflammation process in high-fat diet-induced obese mice. |
| Zhong B, Li FL, Zhao JY, Fu Y, Peng C. |
| Food Nutr Res. 2022 Oct 12;66. doi: 10.29219/fnr.v66.8745. eCollection 2022. |
| Christensenella regulated by Huang-Qi-Ling-Hua-San is a key factor by which to improve type 2 diabetes. |
| Pan T, Zheng S, Zheng W, Shi C, Ning K, Zhang Q, Xie Y, Xiang H, Xie Q. |
| Front Microbiol. 2022 Oct 12;13:1022403. doi: 10.3389/fmicb.2022.1022403. eCollection 2022. |
| Two Laminaria japonica Fermentation Broths Alleviate Oxidative Stress and Inflammatory Response Caused by UVB Damage: Photoprotective and Reparative Effects. |
| Sun Q, Fang J, Wang Z, Song Z, Geng J, Wang D, Wang C, Li M. |
| Mar Drugs. 2022 Oct 20;20(10):650. doi: 10.3390/md20100650. |
| Removing the sporoderm from the sporoderm-broken spores of Ganoderma lucidum improves the anticancer and immune-regulatory activity of the water-soluble polysaccharide. |
| Fang L, Zhao Q, Guo C, Guo D, Li Z, Xu J, Guo C, Sang T, Wang Y, Chen J, Chen C, Chen R, Wu J, Wang X. |
| Front Nutr. 2022 Sep 16;9:1006127. doi: 10.3389/fnut.2022.1006127. eCollection 2022. |
| Fungi composition in settled dust associated with fractional exhaled nitric oxide in school children with asthma. |
| Isa KNM, Jalaludin J, Hashim Z, Than LTL, Hashim JH, Norbäck D. |
| Sci Total Environ. 2022 Dec 20;853:158639. doi: 10.1016/j.scitotenv.2022.158639. Epub 2022 Sep 9. |
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| Ganoderma Lucidum Triterpenoids Improve Maternal Separation-Induced Anxiety- and Depression-like Behaviors in Mice by Mitigating Inflammation in the Periphery and Brain. |
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| Inhibition on α-Glucosidase Activity and Non-Enzymatic Glycation by an Anti-Oxidative Proteoglycan from Ganoderma lucidum. |
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| Triterpenoids and meroterpenoids from the edible Ganoderma resinaceum and their potential anti-inflammatory, antioxidant and anti-apoptosis activities. |
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| Sexual Crossing, Chromosome-Level Genome Sequences, and Comparative Genomic Analyses for the Medicinal Mushroom Taiwanofungus Camphoratus (Syn. Antrodia Cinnamomea, Antrodia Camphorata). |
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| Polysaccharide from Ganoderma lucidum alleviates cognitive impairment in a mouse model of chronic cerebral hypoperfusion by regulating CD4+CD25+Foxp3+ regulatory T cells. |
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| Comparison of the healing effects of mesazaline and Ganoderma lucidum in acetic acid-induced colitis in rats. |
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| Ganoderma modulates allergic asthma pathologic features via anti-inflammatory effects. |
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| Ganoderma applanatum polysaccharides and ethanol extracts promote the recovery of colitis through intestinal barrier protection and gut microbiota modulations. |
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| A polysaccharide isolated from Ganoderma lucidum ameliorates hyperglycemia through modulating gut microbiota in type 2 diabetic mice. |
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| Novelkaraya gum micro-particles loaded Ganoderma lucidum polysaccharide regulate sex hormones, oxidative stress and inflammatory cytokine levels in cadmium induced testicular toxicity in experimental animals. |
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| Ganoderic Acid A Attenuates IL-1β-Induced Inflammation in Human Nucleus Pulposus Cells Through Inhibiting the NF-κB Pathway. |
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| Effects of natural extracts in the treatment of oral ulcers: A systematic review of evidence from experimental studies in animals. |
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| Ganoderterpene A, a New Triterpenoid from Ganoderma lucidum, Attenuates LPS-Induced Inflammation and Apoptosis via Suppressing MAPK and TLR-4/NF-κB Pathways in BV-2 Cells. |
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| Ganoderic Acids Prevent Renal Ischemia Reperfusion Injury by Inhibiting Inflammation and Apoptosis. |
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| A blend of 3 mushrooms dose-dependently increases butyrate production by the gut microbiota. |
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| Benef Microbes. 2021 Nov 16;12(6):601-612. doi: 10.3920/BM2021.0015. Epub 2021 Sep 30. |
| Ganoderma lucidum polysaccharides protect against sepsis-induced cardiac dysfunction by activating SIRT1. |
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| J Pharm Pharmacol. 2022 Jan 5;74(1):124-130. doi: 10.1093/jpp/rgab142. |
| FPR2-based anti-inflammatory and anti-lipogenesis activities of novel meroterpenoid dimers from Ganoderma. |
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| Ganoderic Acid A-Mediated Modulation of Microglial Polarization is Involved in Depressive-Like Behaviors and Neuroinflammation in a Rat Model of Post-Stroke Depression. |
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| Ganoderma lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties. |
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| Postharvest Drying Techniques Regulate Secondary Metabolites and Anti-Neuroinflammatory Activities of Ganoderma lucidum. |
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| Molecules. 2021 Jul 25;26(15):4484. doi: 10.3390/molecules26154484. |
| Rationalization of Mushroom-Based Preventive and Therapeutic Approaches to COVID-19: Review. |
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| Int J Med Mushrooms. 2021;23(5):1-11. doi: 10.1615/IntJMedMushrooms.2021038285. |
| Polysaccharide from Ganoderma lucidum ameliorates cognitive impairment by regulating the inflammation of the brain-liver axis in rats. |
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| Metagenomic characterization of indoor dust fungal associated with allergy and lung inflammation among school children. |
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| Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon. |
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| Anti-oxidant, anti-inflammatory and anti-fibrosis effects of ganoderic acid A on carbon tetrachloride induced nephrotoxicity by regulating the Trx/TrxR and JAK/ROCK pathway. |
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| Ganoderma lucidum triterpenoids and polysaccharides attenuate atherosclerotic plaque in high-fat diet rabbits. |
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| Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor. |
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| Ganoderma lucidum ameliorates the diabetic nephropathy via down-regulatory effect on TGFβ-1 and TLR-4/NFκB signalling pathways. |
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| Ganoderic Acid A Attenuates LPS-Induced Neuroinflammation in BV2 Microglia by Activating Farnesoid X Receptor. |
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| Structural characterization and amelioration of sulfated polysaccharides from Ganoderma applanatum residue against CCl4-induced hepatotoxicity. |
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| Effects of Ganoderma lucidum Polysaccharides on Different Pathways Involved in the Development of Spinal Cord Ischemia Reperfusion Injury: Biochemical, Histopathologic, and Ultrastructural Analysis in a Rat Model. |
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| Characterization and Hepatoprotections of Ganoderma lucidum Polysaccharides against Multiple Organ Dysfunction Syndrome in Mice. |
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| Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor. |
| Abulizi A, Hu L, Ma A, Shao FY, Zhu HZ, Lin SM, Shao GY, Xu Y, Ran JH, Li J, Zhou H, Lin DM, Wang LF, Li M, Yang BX. |
| Acta Pharmacol Sin. 2021 Apr 29. doi: 10.1038/s41401-021-00669-6. Online ahead of print. |
| Ganoderma lucidum ameliorates the diabetic nephropathy via down-regulatory effect on TGFbeta-1 and TLR-4/NFkappaB signalling pathways. |
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| Structural characterization and amelioration of sulfated polysaccharides from Ganoderma applanatum residue against CCl(4)-induced hepatotoxicity. |
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| PLGA nanoparticles containing Lingzhi extracts rescue corneal epithelial cells from oxidative damage. |
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| Exp Eye Res. 2021 May;206:108539. doi: 10.1016/j.exer.2021.108539. Epub 2021 Mar 17. |
| Ganoderma lucidum polysaccharides ameliorated depression-like behaviors in the chronic social defeat stress depression model via modulation of Dectin-1 and the innate immune system. |
| Li H, Xiao Y, Han L, Jia Y, Luo S, Zhang D, Zhang L, Wu P, Xiao C, Kan W, Du J, Bao H. |
| Brain Res Bull. 2021 Jun;171:16-24. doi: 10.1016/j.brainresbull.2021.03.002. Epub 2021 Mar 8. |
| Effects of Ganoderma lucidum Polysaccharides on Different Pathways Involved in the Development of Spinal Cord Ischemia Reperfusion Injury: Biochemical, Histopathologic, and Ultrastructural Analysis in a Rat Model. |
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| Prevention of dextran sulfate sodium-induced mouse colitis by the fungal protein Ling Zhi-8 via promoting the barrier function of intestinal epithelial cells. |
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| Food Funct. 2021 Mar 1;12(4):1639-1650. doi: 10.1039/d0fo02604b. |
| Anti-inflammatory effects of Ganoderma lucidum sterols via attenuation of the p38 MAPK and NF-kappaB pathways in LPS-induced RAW 264.7 macrophages. |
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| Food Chem Toxicol. 2021 Apr;150:112073. doi: 10.1016/j.fct.2021.112073. Epub 2021 Feb 22. |
| Genome sequencing and annotation and phylogenomic analysis of the medicinal mushroom Amauroderma rugosum, a traditional medicinal species in the family Ganodermataceae. |
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| Mycologia. 2021 Mar-Apr;113(2):268-277. doi: 10.1080/00275514.2020.1851135. Epub 2021 Feb 8. |
| Suppression of obesity and inflammation by polysaccharide from sporoderm-broken spore of Ganoderma lucidum via gut microbiota regulation. |
| Sang T, Guo C, Guo D, Wu J, Wang Y, Wang Y, Chen J, Chen C, Wu K, Na K, Li K, Fang L, Guo C, Wang X. |
| Carbohydr Polym. 2021 Mar 15;256:117594. doi: 10.1016/j.carbpol.2020.117594. Epub 2021 Jan 4. |
| The protective effects of the Ganoderma atrum polysaccharide against acrylamide-induced inflammation and oxidative damage in rats. |
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| Food Funct. 2021 Jan 7;12(1):397-407. doi: 10.1039/d0fo01873b. Epub 2020 Dec 18. |
| Effect and Mechanism of Ganoderma lucidum Spores on Alleviation of Diabetic Cardiomyopathy in a Pilot in vivo Study. |
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| Lanostane Triterpenoids from the Fruiting Bodies of Fomes officinalis and Their Anti-Inflammatory Activities. |
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| Molecules. 2020 Oct 19;25(20):4807. doi: 10.3390/molecules25204807. |
| Natural compounds against doxorubicin-induced cardiotoxicity: A review on the involvement of Nrf2/ARE signaling pathway. |
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| Ganoderma Lucidum from Red Mushroom Attenuates Formaldehyde-Induced Liver Damage in Experimental Male Rat Model. |
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| Biology (Basel). 2020 Sep 27;9(10):313. doi: 10.3390/biology9100313. |
| New advances and potentials of fungal immunomodulatory proteins for therapeutic purposes. |
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| Recombinant ling zhi-8 enhances Tregs function to restore glycemic control in streptozocin-induced diabetic rats. |
| Xiao H, Fang Z, He X, Ding P, Cao Y, Chan S, Hou S, Liang J. |
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| Optimization of antioxidant, anti-diabetic, and anti-inflammatory activities and ganoderic acid content of differentially dried Ganoderma lucidum using response surface methodology. |
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| Food Chem. 2021 Jan 15;335:127645. doi: 10.1016/j.foodchem.2020.127645. Epub 2020 Jul 25. |
| The effect of Ganoderma lucidum spore oil in early skin wound healing: interactions of skin microbiota and inflammation. |
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| A recombinant protein rLZ-8, originally extracted from Ganoderma lucidum, ameliorates OVA-induced lung inflammation by regulating Th17/Treg balance. |
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| Involvement of NFkB and MAPK signaling pathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS. |
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| Novel Medicinal Mushroom Blend as a Promising Supplement in Integrative Oncology: A Multi-Tiered Study using 4T1 Triple-Negative Mouse Breast Cancer Model. |
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| Regulatory effects of Ganoderma atrum polysaccharides on LPS-induced inflammatory macrophages model and intestinal-like Caco-2/macrophages co-culture inflammation model. |
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| Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety. |
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| Recombinant Lactococcus lactis Expressing Ling Zhi 8 Protein Ameliorates Nonalcoholic Fatty Liver and Early Atherogenesis in Cholesterol-Fed Rabbits. |
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| A Ganoderma-Derived Compound Exerts Inhibitory Effect Through Formyl Peptide Receptor 2. |
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| Ganoderma Lucidum Polysaccharides Ameliorates Hepatic Steatosis and Oxidative Stress in db/db Mice via Targeting Nuclear Factor E2 (Erythroid-Derived 2)-Related Factor-2/Heme Oxygenase-1 (HO-1) Pathway. |
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| Decreasing angiogenesis vasa vasorum through Lp-PLA2 and H2O2 inhibition by PSP from Ganoderma lucidum in atherosclerosis: in vivo diabetes mellitus type 2. |
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| Deacetyl Ganoderic Acid F Inhibits LPS-Induced Neural Inflammation via NF-κB Pathway Both In Vitro and In Vivo. |
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| Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Renal Diseases and Clinical Applications. |
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