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Ganoderma lucidum polysaccharide promotes broiler health by regulating lipid metabolism, antioxidants, and intestinal microflora.
Gao YY, Zhou YH, Liu XP, Di B, He JY, Wang YT, Guo PT, Zhang J, Wang CK, Jin L.
Int J Biol Macromol. 2024 Sep 23;280(Pt 3):135918. doi: 10.1016/j.ijbiomac.2024.135918. Online ahead of print.
 
Ganoderma lucidum spore oil attenuates acute liver injury by modulating lipid metabolism and gut microbiota.
Liu J, Chen Y, Cen Z, Hong M, Zhang B, Luo X, Wang L, Li S, Xiao X, Long Q.
J Pharm Biomed Anal. 2025 Apr 15;256:116674. doi: 10.1016/j.jpba.2025.116674. Epub 2025 Jan 16.
 
Acidic polysaccharide from Ganoderma tsugae: Structural characterization and antiatherosclerotic related to macrophage polarization.
Zhang X, Liu S, Kong F, Shu L, Li Y, Wang D, Li L.
Food Res Int. 2025 Feb;203:115913. doi: 10.1016/j.foodres.2025.115913. Epub 2025 Feb 3.
 
Alcoholic Extracts from the Ganoderma Lucidum Fermentation Product Alleviated Ethanol-Induced Liver Injury, Gut Leakiness, and Gut Dysbiosis in Mice.
Zhao Z, Ma X, Li M, Chen G, Qi L, Song S, Li Z, Yan C.
Plant Foods Hum Nutr. 2024 Dec 5;80(1):2. doi: 10.1007/s11130-024-01271-x.
 
High molecular weight polysaccharides from Ganoderma lucidum attenuates inflammatory responses, gut microbiota, and liver metabolomic in lipopolysaccharide-induced liver injury mice.
Guo W, Liu W, Liang P, Ni L, Lv X, Fan J, Shi F.
Int J Biol Macromol. 2025 Jan;287:138400. doi: 10.1016/j.ijbiomac.2024.138400. Epub 2024 Dec 8.
 
Use of Herbal Drugs in Cardiovascular Disease- A Review.
Kaur A, Kumar R.
Curr Cardiol Rev. 2025;21(1):e1573403X323724. doi: 10.2174/011573403X323724240830075719.
 
Clinical Evaluation of Ganoderma lucidum Spore Oil for Triglyceride Reduction: A Randomized, Double-Blind, Crossover Study.
Wang X, Wang X, Zhao L, Zhou F.
Nutrients. 2025 Feb 28;17(5):844. doi: 10.3390/nu17050844.
 
Mushrooms as Nutritional Powerhouses: A Review of Their Bioactive Compounds, Health Benefits, and Value-Added Products.
Singh A, Saini RK, Kumar A, Chawla P, Kaushik R.
Foods. 2025 Feb 22;14(5):741. doi: 10.3390/foods14050741.
 
Structural characteristics of a heteropolysaccharide from Ganoderma lucidum and its protective effect against Alzheimer's disease via modulating the microbiota-gut-metabolomics.
Chen L, Wang X, Sun J, Xue J, Yang X, Zhang Y.
Int J Biol Macromol. 2025 Mar;297:139863. doi: 10.1016/j.ijbiomac.2025.139863. Epub 2025 Jan 13.
 
Changes of Active Substances in Ganoderma lucidum during Different Growth Periods and Analysis of Their Molecular Mechanism.
Gao X, Huo H, Bao H, Wang J, Gao D.
Molecules. 2024 May 31;29(11):2591. doi: 10.3390/molecules29112591.

EFFECT OF DRY EXTRACT FROM REISHI MUSHROOMS ON THE STATE OF ANTIOXIDANT SYSTEM IN RATS WITH DMH-INDUCED COLON CARCINOGENESIS.
Herasymets I, Fira L, Medvid I, Fira D, Yasinovskyi O, Grytsyshyn L.
Wiad Lek. 2023;76(12):2632-2640. doi: 10.36740/WLek202312112.
 
The protective effect of PL 1-3 on D-galactose-induced aging mice.
Li P, Ma Y, Wang X, Li X, Wang X, Yang J, Liu G.
Front Pharmacol. 2024 Jan 3;14:1304801. doi: 10.3389/fphar.2023.1304801. eCollection 2023.
 
Effect of Ganoderma lucidum on serum lipid profiles: A systematic review and meta-analysis on animal studies.
Aref M, Khoshhali M, Ghasemi P, Adeli S, Heidari-Beni M, Kelishadi R.
J Res Med Sci. 2023 Sep 29;28:70. doi: 10.4103/jrms.jrms_175_23. eCollection 2023.
 
Proteomics and network pharmacology of Ganshu Nuodan capsules in the prevention of alcoholic liver disease.
Yang X, Wang L, Cui X, Zhang J, Liang Y, Luo Z, Zhou B, Jiang Z, Yang RYH, Wu Y, Wei K, Du M, Qin S, Dai C, Zhao G.
Front Endocrinol (Lausanne). 2023 Sep 18;14:1229777. doi: 10.3389/fendo.2023.1229777. eCollection 2023.
 
Triterpenoids of Ganoderma lucidum inhibited S180 sarcoma and H22 hepatoma in mice by regulating gut microbiota.
Wang J, Pu J, Zhang Z, Feng Z, Han J, Su X, Shi L.
Heliyon. 2023 Jun 7;9(6):e16682. doi: 10.1016/j.heliyon.2023.e16682. eCollection 2023 Jun.
 
Edible and medicinal mushrooms (Pleurotus ostreatus, Ustilago maydis, Ganoderma lucidum) reduce endoplasmic reticulum stress and inflammation in adipose tissue of obese Wistar rats fed with a high fat plus saccharose diet.
González-Ibáñez L, Meneses ME, Sánchez-Tapia M, Pérez-Luna D, Torres N, Torre-Villalvazo I, Bonilla M, Petlacalco B, Castillo I, López-Barradas A, Macías A, Tovar AR, Martínez-Carrera D.
Food Funct. 2023 Jun 6;14(11):5048-5061. doi: 10.1039/d3fo00089c.
 
The Medicinal Mushroom Ganoderma neo-japonicum (Agaricomycetes) Polysaccharide Extract Prevents Obesity-Induced Diabetes in C57BL/6J Mice.
Subramaniam S, Ong KC, Sabaratnam V, Chua KH, Kuppusamy UR.
Int J Med Mushrooms. 2023;25(4):27-42. doi: 10.1615/IntJMedMushrooms.2023047595.
 
A proteoglycan isolated from Ganoderma lucidum attenuates diabetic kidney disease by inhibiting oxidative stress-induced renal fibrosis both in vitro and in vivo.
Pan Y, Zhang Y, Li J, Zhang Z, He Y, Zhao Q, Yang H, Zhou P.
J Ethnopharmacol. 2023 Jun 28;310:116405. doi: 10.1016/j.jep.2023.116405. Epub 2023 Mar 24.
 
Protective Effect of Ganoderma lucidum Spore Powder on Acute Liver Injury in Mice and its Regulation of Gut Microbiota.
Leng Y, Wang F, Chen C, Wan X, Li X, Wang H, Wang S.
Front Biosci (Landmark Ed). 2023 Feb 2;28(2):23. doi: 10.31083/j.fbl2802023.
 
Modulation of gut microbiota and lipid metabolism in rats fed high-fat diets by Ganoderma lucidum triterpenoids.
Tong A, Wu W, Chen Z, Wen J, Jia R, Liu B, Cao H, Zhao C.
Curr Res Food Sci. 2022 Dec 27;6:100427. doi: 10.1016/j.crfs.2022.100427. eCollection 2023.
 
Sporoderm-broken spore powder of Ganoderma lucidum ameliorate obesity and inflammation process in high-fat diet-induced obese mice.
Zhong B, Li FL, Zhao JY, Fu Y, Peng C.
Food Nutr Res. 2022 Oct 12;66. doi: 10.29219/fnr.v66.8745. eCollection 2022.
 
Adenosine-rich extract of Ganoderma lucidum: A safe and effective lipid-lowering substance.
Li H, Du Y, Ji H, Yang Y, Xu C, Li Q, Ran L, Wu C, Zhou Q, Wu S.
iScience. 2022 Sep 26;25(11):105214. doi: 10.1016/j.isci.2022.105214. eCollection 2022 Nov 18.
 
Ganoderic acid A improves osteoarthritis by regulating RANKL/OPG ratio.
Wu W, Song K, Chen G, Liu N, Cao T.
Chem Biol Drug Des. 2022 Sep;100(3):313-319. doi: 10.1111/cbdd.14101. Epub 2022 Jun 28.
 
Association of gut microbiota characteristics and metabolites reveals the regulation mechanisms under cadmium consumption circumstance.
Dai Z, Liu J, Yao X, Wang A, Liu Y, Strappe P, Huang W, Zhou Z.
J Sci Food Agric. 2022 Nov;102(14):6737-6748. doi: 10.1002/jsfa.12041. Epub 2022 Jun 21.
 
Ganoderic acid A from Ganoderma lucidum protects against alcoholic liver injury through ameliorating the lipid metabolism and modulating the intestinal microbial composition.
Lv XC, Wu Q, Cao YJ, Lin YC, Guo WL, Rao PF, Zhang YY, Chen YT, Ai LZ, Ni L.
Food Funct. 2022 May 23;13(10):5820-5837. doi: 10.1039/d1fo03219d.
 
Ganoderic acids alleviate atherosclerosis by inhibiting macrophage M1 polarization via TLR4/MyD88/NF-κB signaling pathway.
Quan YZ, Ma A, Ren CQ, An YP, Qiao PS, Gao C, Zhang YK, Li XW, Lin SM, Li NN, Chen DL, Pan Y, Zhou H, Lin DM, Lin SQ, Li M, Yang BX.
Atherosclerosis. 2024 Feb 8;391:117478. doi: 10.1016/j.atherosclerosis.2024.117478. Online ahead of print.
 
Ganoderma lucidum polysaccharide ameliorates cholesterol gallstone formation by modulating cholesterol and bile acid metabolism in an FXR-dependent manner.
Huang D, Shen S, Zhuang Q, Ye X, Qian Y, Dong Z, Wan X.
Chin Med. 2024 Jan 24;19(1):16. doi: 10.1186/s13020-024-00889-y.
 
In vitro cholesterol lowering activity of Ganoderma australe mycelia based on mass spectrometry, synchrotron Fourier-transform infrared analysis and liver-spheroid bioactivity.
Wongkhieo S, Tangmesupphaisan W, Siriwaseree J, Aramsirirujiwet Y, Wiriyajitsomboon P, Kaewgrajang T, Pumloifa S, Paemanee A, Kuaprasert B, Choowongkomon K, Chester AH, Swainson NM.
Sci Rep. 2023 Aug 21;13(1):13619. doi: 10.1038/s41598-023-40861-8.
 
Effect of the Lingzi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) on Hyperglycemia and Dyslipidemia with Experimental Metabolic Syndrome.
Petryn TS, Nagalievska MR, Wasser SP, Sybirna NO.
Int J Med Mushrooms. 2023;25(5):17-30. doi: 10.1615/IntJMedMushrooms.2023047834.
 
Effects of Mexican Ganoderma lucidum extracts on liver, kidney, and the gut microbiota of Wistar rats: A repeated dose oral toxicity study.
Meneses ME, Martínez-Carrera D, González-Ibáñez L, Torres N, Sánchez-Tapia M, Márquez-Mota CC, Rendón G, Mitzi V, Morales A, Tello-Salgado I, Tovar AR.
PLoS One. 2023 Apr 6;18(4):e0283605. doi: 10.1371/journal.pone.0283605. eCollection 2023.
 
Exploring Edible Mushrooms for Diabetes: Unveiling Their Role in Prevention and Treatment.
Shamim MZ, Mishra AK, Kausar T, Mahanta S, Sarma B, Kumar V, Mishra PK, Panda J, Baek KH, Mohanta YK.
Molecules. 2023 Mar 21;28(6):2837. doi: 10.3390/molecules28062837.
 
GLSP and GLSP-derived triterpenes attenuate atherosclerosis and aortic calcification by stimulating ABCA1/G1-mediated macrophage cholesterol efflux and inactivating RUNX2-mediated VSMC osteogenesis.
Zheng G, Zhao Y, Li Z, Hua Y, Zhang J, Miao Y, Guo Y, Li L, Shi J, Dong Z, Yang S, Fan G, Ma C.
Theranostics. 2023 Feb 21;13(4):1325-1341. doi: 10.7150/thno.80250. eCollection 2023.
 
Ganoderma lucidum polysaccharides improve lipid metabolism against high-fat diet-induced dyslipidemia.
Wang W, Zhang Y, Wang Z, Zhang J, Jia L.
J Ethnopharmacol. 2023 Jun 12;309:116321. doi: 10.1016/j.jep.2023.116321. Epub 2023 Mar 1.
 
Organic chromium derived from the chelation of Ganoderma lucidum polysaccharide and chromium (III) alleviates metabolic syndromes and intestinal microbiota dysbiosis induced by high-fat and high-fructose diet.
Lv XC, Wu Q, Yuan YJ, Li L, Guo WL, Lin XB, Huang ZR, Rao PF, Ai LZ, Ni L.
Int J Biol Macromol. 2022 Oct 31;219:964-979. doi: 10.1016/j.ijbiomac.2022.07.211. Epub 2022 Aug 6.

The Protective Effects of Ganoderic Acids from Ganoderma lucidum Fruiting Body on Alcoholic Liver Injury and Intestinal Microflora Disturbance in Mice with Excessive Alcohol Intake.
Cao YJ, Huang ZR, You SZ, Guo WL, Zhang F, Liu B, Lv XC, Lin ZX, Liu PH.
Foods. 2022 Mar 25;11(7):949. doi: 10.3390/foods11070949.
 
Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with excessive alcohol intake.
Guo WL, Cao YJ, You SZ, Wu Q, Zhang F, Han JZ, Lv XC, Rao PF, Ai LZ, Ni L.
Curr Res Food Sci. 2022 Feb 24;5:515-530. doi: 10.1016/j.crfs.2022.02.013. eCollection 2022.
 
Antidyslipidemic Potential of Water-Soluble Polysaccharides of Ganoderma applanatum in MACAPOS-2-Induced Obese Rats.
Mfopa A, Mediesse FK, Mvongo C, Nkoubatchoundjwen S, Lum AA, Sobngwi E, Kamgang R, Boudjeko T.
Evid Based Complement Alternat Med. 2021 Aug 18;2021:2452057. doi: 10.1155/2021/2452057. eCollection 2021.
 
Significant effects of Ganoderma lucidum polysaccharide on lipid metabolism in diabetes may be associated with the activation of the FAM3C-HSF1-CAM signaling pathway.
Pan R, Lou J, Wei L.
Exp Ther Med. 2021 Aug;22(2):820. doi: 10.3892/etm.2021.10252. Epub 2021 Jun 2.
 
Anti-oxidant, anti-inflammatory and anti-fibrosis effects of ganoderic acid A on carbon tetrachloride induced nephrotoxicity by regulating the Trx/TrxR and JAK/ROCK pathway.
Ma JQ, Zhang YJ, Tian ZK.
Chem Biol Interact. 2021 Aug 1;344:109529. doi: 10.1016/j.cbi.2021.109529. Epub 2021 May 23.
 
Ganoderma lucidum triterpenoids and polysaccharides attenuate atherosclerotic plaque in high-fat diet rabbits.
Li Y, Tang J, Gao H, Xu Y, Han Y, Shang H, Lu Y, Qin C.
Nutr Metab Cardiovasc Dis. 2021 Jun 7;31(6):1929-1938. doi: 10.1016/j.numecd.2021.03.023. Epub 2021 Apr 6.
 
Ganoderma lucidum spore ethanol extract attenuates atherosclerosis by regulating lipid metabolism via upregulation of liver X receptor alpha.
Lai P, Cao X, Xu Q, Liu Y, Li R, Zhang J, Zhang M.
Pharm Biol. 2020 Dec;58(1):760-770. doi: 10.1080/13880209.2020.1798471.
 
Ganoderma lucidum Extract Reduces Insulin Resistance by Enhancing AMPK Activation in High-Fat Diet-Induced Obese Mice.
Lee HA, Cho JH, Afinanisa Q, An GH, Han JG, Kang HJ, Choi SH, Seong HA.
Nutrients. 2020 Oct 30;12(11):3338. doi: 10.3390/nu12113338.
 
Recombinant ling zhi-8 enhances Tregs function to restore glycemic control in streptozocin-induced diabetic rats.
Xiao H, Fang Z, He X, Ding P, Cao Y, Chan S, Hou S, Liang J.
J Pharm Pharmacol. 2020 Dec;72(12):1946-1955. doi: 10.1111/jphp.13360. Epub 2020 Aug 17.
 
The effect of Ganoderma lucidum spore oil in early skin wound healing: interactions of skin microbiota and inflammation.
Jiao C, Xie Y, Yun H, Liang H, He C, Jiang A, Wu Q, Yang BB.
Aging (Albany NY). 2020 Jul 21;12(14):14125-14140. doi: 10.18632/aging.103412. Epub 2020 Jul 21.
 
Ganoderic acid A from Ganoderma lucidum ameliorates lipid metabolism and alters gut microbiota composition in hyperlipidemic mice fed a high-fat diet.
Guo WL , Guo JB , Liu BY , Lu JQ , Chen M , Liu B , Bai WD , Rao PF , Ni L , Lv XC .
Food Funct. 2020 Aug 1;11(8):6818-6833. doi: 10.1039/d0fo00436g. Epub 2020 Jul 20.
 
Effect of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Capsules on Colistin-Induced Nephrotoxicity.
Talih G, Kantekin ÇÜ, Göçmen Y, Çelik S, Talih T, Esmaoğlu A.
Int J Med Mushrooms. 2020;22(5):445-453. doi: 10.1615/IntJMedMushrooms.2020034229.
 
Deacetyl Ganoderic Acid F Inhibits LPS-Induced Neural Inflammation via NF-κB Pathway Both In Vitro and In Vivo.
Sheng F, Zhang L, Wang S, Yang L, Li P.
Nutrients. 2019 Dec 27;12(1):85. doi: 10.3390/nu12010085.
 
Protective effect of Ganoderma atrum polysaccharides in acute lung injury rats and its metabolomics.
Li L, Fu WW, Wu RT, Song YH, Wu WY, Yin SH, Li WJ, Xie MY.
Int J Biol Macromol. 2020 Jan 1;142:693-704. doi: 10.1016/j.ijbiomac.2019.10.010. Epub 2019 Nov 15.
 
Antiangiogenic and Proapoptotic Activities of Atorvastatin and Ganoderma lucidum in Tumor Mouse Model via VEGF and Caspase-3 Pathways.
El-Khashab IH.
Asian Pac J Cancer Prev. 2021 Apr 1;22(4):1095-1104. doi: 10.31557/APJCP.2021.22.4.1095.
 
Effects of Ganoderma lucidum and Ceratonia siliqua on blood glucose, lipid profile, and body composition in women with fibromyalgia.
Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MÁ, Gusi N, Collado-Mateo D.
Nutr Hosp. 2021 Feb 23;38(1):139-145. doi: 10.20960/nh.03190.
 
Protective effect of Ganoderma lucidum spore extract in trimethylamine-N-oxide-induced cardiac dysfunction in rats.
Liu Y, Lai G, Guo Y, Tang X, Shuai O, Xie Y, Wu Q, Chen D, Yuan X.
J Food Sci. 2021 Feb;86(2):546-562. doi: 10.1111/1750-3841.15575. Epub 2021 Jan 12.
 
Mexican Ganoderma Lucidum Extracts Decrease Lipogenesis Modulating Transcriptional Metabolic Networks and Gut Microbiota in C57BL/6 Mice Fed with a High-Cholesterol Diet.
Romero-Córdoba SL, Salido-Guadarrama I, Meneses ME, Cosentino G, Iorio MV, Tagliabue E, Torres N, Sánchez-Tapia M, Bonilla M, Castillo I, Petlacalco B, Tovar AR, Martínez-Carrera D.
Nutrients. 2020 Dec 24;13(1):38. doi: 10.3390/nu13010038.
 
Pathophysiology of cardiovascular diseases and role of vitamins, herbal extracts in the reduction of cardiovascular risks.
Kumar R, Malik S, Tiwari R, Zhautivova SB, Rakhimovna AH, Raj T, Kumar P.
Cardiovasc Hematol Agents Med Chem. 2020 Dec 16. doi: 10.2174/1871525718666201217102638.
 
Dingxin Recipe IV attenuates atherosclerosis by regulating lipid metabolism through LXR-α/SREBP1 pathway and modulating the gut microbiota in ApoE-/- mice fed with HFD.
Zhang Y, Gu Y, Chen Y, Huang Z, Li M, Jiang W, Chen J, Rao W, Luo S, Chen Y, Chen J, Li L, Jia Y, Liu M, Zhou F.
J Ethnopharmacol. 2021 Feb 10;266:113436. doi: 10.1016/j.jep.2020.113436. Epub 2020 Oct 1.
 
Inhibitory kinetics and bioactivities of Nuciferine and Methyl Ganoderate on Mucor miehei lipase and 3T3-L1 preadipocytes.
Liu XT, Liu TT, Xu HL, Chen QX, Wang Q.
Int J Biol Macromol. 2020 Nov 15;163:1719-1728. doi: 10.1016/j.ijbiomac.2020.09.127. Epub 2020 Sep 21.
 
Highly oxygenated lanostane triterpenoids from Ganoderma applanatum as a class of agents for inhibiting lipid accumulation in adipocytes.
Su HG, Wang Q, Zhou L, Peng XR, Xiong WY, Qiu MH.
Bioorg Chem. 2020 Nov;104:104263. doi: 10.1016/j.bioorg.2020.104263. Epub 2020 Sep 3.
 
Amelioration of the Lipogenesis, Oxidative Stress and Apoptosis of Hepatocytes by a Novel Proteoglycan from Ganoderma lucidum.
Yuan S, Pan Y, Zhang Z, He Y, Teng Y, Liang H, Wu X, Yang H, Zhou P.
Biol Pharm Bull. 2020 Oct 1;43(10):1542-1550. doi: 10.1248/bpb.b20-00358. Epub 2020 Aug 5.
 
Recombinant Lactococcus lactis Expressing Ling Zhi 8 Protein Ameliorates Nonalcoholic Fatty Liver and Early Atherogenesis in Cholesterol-Fed Rabbits.
Lee MF, Chiang CH, Lin SJ, Song PP, Liu HC, Wu TJ, Lin WW.
Biomed Res Int. 2020 Jan 27;2020:3495682. doi: 10.1155/2020/3495682. eCollection 2020.
 
Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes) Ameliorates Spatial Learning and Memory Deficits in Rats with Hypercholesterolemia and Alzheimer's Disease.
Rahman MA, Hossain S, Abdullah N, Aminudin N.
Int J Med Mushrooms. 2020;22(1):93-103. doi: 10.1615/IntJMedMushrooms.2020033383.
 
Ganoderma polysaccharide and chitosan synergistically ameliorate lipid metabolic disorders and modulate gut microbiota composition in high fat diet-fed golden hamsters.
Tong AJ, Hu RK, Wu LX, Lv XC, Li X, Zhao LN, Liu B.
J Food Biochem. 2020 Jan;44(1):e13109. doi: 10.1111/jfbc.13109. Epub 2019 Dec 3.
 
Characterization, hypolipidemic and antioxidant activities of degraded polysaccharides from Ganoderma lucidum.
Xu Y, Zhang X, Yan XH, Zhang JL, Wang LY, Xue H, Jiang GC, Ma XT, Liu XJ.
Int J Biol Macromol. 2019 Aug 15;135:706-716. doi: 10.1016/j.ijbiomac.2019.05.166. Epub 2019 May 23.
 
Decreasing angiogenesis vasa vasorum through Lp-PLA2 and H2O2 inhibition by PSP from Ganoderma lucidum in atherosclerosis: in vivo diabetes mellitus type 2.
Wihastuti TA, Amiruddin R, Cesa FY, Alkaf AI, Setiawan M, Heriansyah T.
J Basic Clin Physiol Pharmacol. 2020 Feb 7;30(6). pii: /j/jbcpp.2019.30.issue-6/jbcpp-2019-0349/jbcpp-2019-0349.xml. doi: 10.1515/jbcpp-2019-0349.
 
Protective Effect of Ganoderma (Lingzhi) on Cardiovascular System.
Meng J, Yang B.
Adv Exp Med Biol. 2019;1182:181-199. doi: 10.1007/978-981-32-9421-9_7. Review.
 
Polysaccharide peptide (PsP) Ganoderma lucidum: a potential inducer for vascular repair in type 2 diabetes mellitus model.
Heriansyah T, Nurwidyaningtyas W, Sargowo D, Tjahjono CT, Wihastuti TA.
Vasc Health Risk Manag. 2019 Oct 3;15:419-427. doi: 10.2147/VHRM.S205996. eCollection 2019. Erratum in: Vasc Health Risk Manag. 2019 Nov 05;15:517.
 
Pharmacological effects of Ganoderma lucidum extract against high-altitude stressors and its subchronic toxicity assessment.
Sharma P, Tulsawani R, Agrawal U.
J Food Biochem. 2019 Dec;43(12):e13081. doi: 10.1111/jfbc.13081. Epub 2019 Oct 14.
 
Preparation of Ganoderma lucidum polysaccharide‑chromium (III) complex and its hypoglycemic and hypolipidemic activities in high-fat and high-fructose diet-induced pre-diabetic mice.
Li L, Xu JX, Cao YJ, Lin YC, Guo WL, Liu JY, Bai WD, Zhang YY, Ni L, Liu B, Rao PF, Lv XC.
Int J Biol Macromol. 2019 Nov 1;140:782-793. doi: 10.1016/j.ijbiomac.2019.08.072. Epub 2019 Aug 8.
 
Determination of genotoxic and antigenotoxic effects of wild-grown Reishi mushroom (Ganoderma lucidum) using the hen's egg test for analysis of micronucleus induction.
Çelik B, Özparlak H.
Biotech Histochem. 2019 Nov;94(8):628-636. doi: 10.1080/10520295.2019.1622784. Epub 2019 Jul 8.
 
Enhanced Ganoderic Acids Accumulation and Transcriptional Responses of Biosynthetic Genes in Ganoderma lucidum Fruiting Bodies by Elicitation Supplementation.
Meng L, Bai X, Zhang S, Zhang M, Zhou S, Mukhtar I, Wang L, Li Z, Wang W.
Int J Mol Sci. 2019 Jun 10;20(11). pii: E2830. doi: 10.3390/ijms20112830.
 
Characterization, hypolipidemic and antioxidant activities of degraded polysaccharides from Ganoderma lucidum.
Xu Y, Zhang X, Yan XH, Zhang JL, Wang LY, Xue H, Jiang GC, Ma XT, Liu XJ.
Int J Biol Macromol. 2019 Aug 15;135:706-716. doi: 10.1016/j.ijbiomac.2019.05.166. Epub 2019 May 23.
 
Effects of Concurrently Administered Aqueous Extract of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), and Lead Acetate in Rats.
Sobowale MT, Ozolua RI, Uwaya DO, Ayinde BA.
Int J Med Mushrooms. 2019;21(2):143-154. doi: 10.1615/IntJMedMushrooms.2019029766.
 
Anti-Inflammatory and Hepatoprotective Effects of Ganoderma lucidum Polysaccharides against Carbon Tetrachloride-Induced Liver Injury in Kunming Mice.
Chen YS, Chen QZ, Wang ZJ, Hua C.
Pharmacology. 2019;103(3-4):143-150. doi: 10.1159/000493896. Epub 2019 Jan 23.
 
Ganoderma lucidum-derived polysaccharide enhances coix oil-based microemulsion on stability and lung cancer-targeted therapy.
Guo J, Yuan C, Huang M, Liu Y, Chen Y, Liu C, Chen Y.
Drug Deliv. 2018 Nov;25(1):1802-1810. doi: 10.1080/10717544.2018.1516006.
 
Hepatoprotective activity of Ganoderma lucidum triterpenoids in alcohol-induced liver injury in mice, an iTRAQ-based proteomic analysis.
Zhao C, Fan J, Liu Y, Guo W, Cao H, Xiao J, Wang Y, Liu B.
Food Chem. 2019 Jan 15;271:148-156. doi: 10.1016/j.foodchem.2018.07.115. Epub 2018 Jul 18.
 
Hypolipidemic, Antioxidant, and Antiapoptotic Effects of Polysaccharides Extracted from Reishi Mushroom, Ganoderma lucidum (Leysser: Fr) Karst, in Mice Fed a High-Fat Diet.
Liang Z, Yuan Z, Li G, Fu F, Shan Y.
J Med Food. 2018 Dec;21(12):1218-1227. doi: 10.1089/jmf.2018.4182. Epub 2018 Sep 5.
 
Hypolipidaemic and anti-lipidperoxidant activities of Ganoderma lucidum polysaccharide.
Wu S.
Int J Biol Macromol. 2018 Oct 15;118(Pt B):2001-2005. doi: 10.1016/j.ijbiomac.2018.07.082. Epub 2018 Jul 22.
 
Ganoderma lucidum Ameliorates Non-Alcoholic Steatosis by Upregulating Energy Metabolizing Enzymes in the Liver.
Jung S, Son H, Hwang CE, Cho KM, Park SW, Kim HJ.
J Clin Med. 2018 Jun 15;7(6). pii: E152. doi: 10.3390/jcm7060152.
 
Ethanol extract of Ganoderma lucidum ameliorates lipid metabolic disorders and modulates the gut microbiota composition in high-fat diet fed rats.
Guo WL, Pan YY, Li L, Li TT, Liu B, Lv XC.
Food Funct. 2018 Jun 20;9(6):3419-3431. doi: 10.1039/c8fo00836a.
 
Evaluation of the Antioxidative and Hypo-cholesterolemic Effects of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Ameliorating Cardiovascular Disease.
Rahman MA, Abdullah N, Aminudin N.
Int J Med Mushrooms. 2018;20(10):961-969. doi: 10.1615/IntJMedMushrooms.2018028370.
 
Ganoderma terpenoid extract exhibited anti-plasmodial activity by a mechanism involving reduction in erythrocyte and hepatic lipids in Plasmodium berghei infected mice.
Oluba OM.
Lipids Health Dis. 2019 Jan 12;18(1):12. doi: 10.1186/s12944-018-0951-x.
 
Ganoderma Lucidum Polysaccharide Peptide Alleviates Hepatoteatosis via Modulating Bile Acid Metabolism Dependent on FXR-SHP/FGF.
Zhong D, Xie Z, Huang B, Zhu S, Wang G, Zhou H, Lin S, Lin Z, Yang B.
Cell Physiol Biochem. 2018;49(3):1163-1179. doi: 10.1159/000493297. Epub 2018 Sep 7.
 
OS 10-03 THE DISTINCTIVE EFFECT OF POLYSACCHARIDE PEPTIDES GANODERMA LUCIDUM AS ANTI ATHEROGENESIS IN STABLE ANGINA PATIENTS.
Ubaidillah N, Sargowo D, Widya A, Jakfar V, Proboretno KS, Failasufi M, Warahugraha Y, Ramadhan F, Wulandari H, Putri DH.
J Hypertens. 2016 Sep;34 Suppl 1 - ISH 2016 Abstract Book:e72.
 
Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors.
Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A.
Cochrane Database Syst Rev. 2015 Feb 17;2:CD007259. doi: 10.1002/14651858.CD007259.pub2.
 
Development of liposomal Ganoderma lucidum polysaccharide: formulation optimization and evaluation of its immunological activity.
Liu Z, Ma X, Deng B, Huang Y, Bo R, Gao Z, Yu Y, Hu Y, Liu J, Wu Y, Wang D.
Carbohydr Polym. 2015 Mar 6;117:510-7. doi: 10.1016/j.carbpol.2014.09.093. Epub 2014 Oct 15.
 
Exopolysaccharide from Ganoderma applanatum as a promising bioactive compound with cytostatic and antibacterial properties.
Osińska-Jaroszuk M, Jaszek M, Mizerska-Dudka M, Błachowicz A, Rejczak TP, Janusz G, Wydrych J, Polak J, Jarosz-Wilkołazka A, Kandefer-Szerszeń M.
Biomed Res Int. 2014;2014:743812. doi: 10.1155/2014/743812. Epub 2014 Jul 10.
 
Evaluation of a crataegus-based multiherb formula for dyslipidemia: a randomized, double-blind, placebo-controlled clinical trial.
Hu M, Zeng W, Tomlinson B.
Evid Based Complement Alternat Med. 2014;2014:365742. doi: 10.1155/2014/365742. Epub 2014 Apr 16.