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Structure-activity relationship of synthesized glucans from Ganoderma lucidum with in vitro hypoglycemic activity.
Yang L, Huang J, Huang N, Qin S, Chen Z, Xiao G, Shao H, Zi C, Hu JM.
Int J Biol Macromol. 2025 Feb;288:138586. doi: 10.1016/j.ijbiomac.2024.138586. Epub 2024 Dec 15.
 
Ganoderma lucidum: Multifaceted mechanisms to combat diabetes through polysaccharides and triterpenoids: A comprehensive review.
Ahmad MF, Ahmad FA, Hasan N, Alsayegh AA, Hakami O, Bantun F, Tasneem S, Alamier WM, Babalghith AO, Aldairi AF, Kambal N, Elbendary EY.
Int J Biol Macromol. 2024 May;268(Pt 1):131644. doi: 10.1016/j.ijbiomac.2024.131644. Epub 2024 Apr 18.
 
A review of polysaccharides from Ganoderma lucidum: Preparation methods, structural characteristics, bioactivities, structure-activity relationships and potential applications.
Yang M, Qin X, Liu X.
Int J Biol Macromol. 2025 Apr;303:140645. doi: 10.1016/j.ijbiomac.2025.140645. Epub 2025 Feb 3.
 
The role of selected nutraceuticals in management of prediabetes and diabetes: An updated review of the literature. Part II.
Derosa G, D'Angelo A, Maffioli P.
Phytother Res. 2024 Nov;38(11):5490-5532. doi: 10.1002/ptr.8312. Epub 2024 Oct 3.
 
The Artist's Conk Medicinal Mushroom Ganoderma applanatum (Agaricomycetes): Mycological, Mycochemical, and Pharmacological Properties: A Review.
Cheng M, Zhang L, Wang J, Sun X, Qi Y, Chen L, Han C.
Int J Med Mushrooms. 2024;26(7):13-66. doi: 10.1615/IntJMedMushrooms.2024053900.
 
Extraction Optimization and Bioactivity of Polysaccharides from Ganoderma leucocontextum Spores.
Peng S, Ou Y, Zhang Y, Yao H, Chen WH
Pharmaceuticals (Basel). 2025 Feb 11;18(2):241. doi: 10.3390/ph18020241.
 
Neuroprotective and antidiabetic lanostane-type triterpenoids from the fruiting bodies of Ganoderma theaecolum.
Guo J, Yang L, Dai L, Ma Q, Yan J, Xie Q, Wu Y, Dai H, Zhao Y.
Chin J Nat Med. 2025 Feb;23(2):245-256. doi: 10.1016/S1875-5364(25)60828-4.
 
Potential Medicinal Fungi from Freshwater Environments as Resources of Bioactive Compounds.
Cicero I, Mirabile G, Venturella G.
J Fungi (Basel). 2025 Jan 10;11(1):54. doi: 10.3390/jof11010054.
 
Identification of Selected Flavonoids Extracted from Cap and Stem of Wild and Cultivated Ganoderma Species (Agaricomycetes) and Bioactivities.
Liu Y, Xia C, Chen BJ, Li X, Wu X, Ismail A, Dong X, Khoo HE.
Int J Med Mushrooms. 2025;27(6):61-79. doi: 10.1615/IntJMedMushrooms.2025058111.
 
Resinacein S ameliorates the obesity in mice via activating the brown adipose tissue.
Chen X, Zou L, Li Y, Peng L, Wang X, Xi Q, Sun F, Ma J.
Pak J Pharm Sci. 2024 Nov-Dec;37(6):1429-1441.
 
Research progress of Ganoderma lucidum polysaccharide in prevention and treatment of Atherosclerosis.
Ma Y, Han J, Wang K, Han H, Hu Y, Li H, Wu S, Zhang L.
Heliyon. 2024 Jun 19;10(12):e33307. doi: 10.1016/j.heliyon.2024.e33307. eCollection 2024 Jun 30.
 
A nanozyme multifunctional platform based on iron doped carbon dots derived from Tibetan Ganoderma lucidum waste for glucose sensing, anti-counterfeiting applications, and anticancer cell effect.
Wang L, Zheng S, Liu Y, Ji Y, Liu X, Wang F, Li C.
Talanta. 2024 Aug 15;276:126262. doi: 10.1016/j.talanta.2024.126262. Epub 2024 May 15.
 
Systems Pharmacology-based Drug Discovery and Active Mechanism of Ganoderma lucidum Triterpenoids for Type 2 Diabetes Mellitus by Integrating Network Pharmacology and Molecular Docking.
Shi J, Chen J, Cheng C, Li W, Li M, Ye S, Liu Z, Ding Y.
Curr Pharm Des. 2025 Feb 13. doi: 10.2174/0113816128365423250126035306. Online ahead of print.
 
Use of Herbal Drugs in Cardiovascular Disease- A Review.
Kaur A, Kumar R.
Curr Cardiol Rev. 2025;21(1):e1573403X323724. doi: 10.2174/011573403X323724240830075719.
 
Extraction, purification, structural characterization, biological activity, mechanism of action and application of polysaccharides from Ganoderma lucidum: A review.
Ding L, Shangguan H, Wang X, Liu J, Shi Y, Xu X, Xie Y.
Int J Biol Macromol. 2025 Feb;288:138575. doi: 10.1016/j.ijbiomac.2024.138575. Epub 2024 Dec 9.
 
Ganoderma tsuage promotes pain sensitivity in aging mice.
Yang KN, Lin CY, Li WN, Tang CM, Pradhan J, Chao MW, Tseng CY.
Sci Rep. 2024 May 21;14(1):11536. doi: 10.1038/s41598-024-61499-0.
 
Ganoderic Acid A Prevented Osteoporosis by Modulating the PIK3CA/p-Akt/TWIST1 Signaling Pathway.
Zhao J, Fan Y, Li H, Wang C, Fan S, Sun H, Liu M.
Food Sci Nutr. 2025 Apr 14;13(4):e70177. doi: 10.1002/fsn3.70177. eCollection 2025 Apr.
 
Lingzhi, Reishi.
[No authors listed]
2024 Oct 5. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–.
 
Ganoderma Microsporum Immunomodulatory Protein Alleviates Inflammaging and Oxidative Stress in Diabetes-Associated Periodontitis via Nrf2 Signaling Activation: An In Vitro Study.
Su NY, Ng MY, Liao HY, Liao YW, Wu M, Chao SC, Yu CC, Chang YC.
Antioxidants (Basel). 2024 Jul 8;13(7):817. doi: 10.3390/antiox13070817.
 
Ganoderma lucidum triterpenoids investigating their role in medicinal applications and genomic protection.
Raza SHA, Zhong R, Li X, Pant SD, Shen X, BinMowyna MN, Luo L, Lei H.
J Pharm Pharmacol. 2024 Dec 2;76(12):1535-1551. doi: 10.1093/jpp/rgae133.
 
Integrating transcriptomics, metabolomics, and network pharmacology to investigate multi-target effects of sporoderm-broken spores of Ganoderma lucidum on improving HFD-induced diabetic nephropathy rats.
Hu L, Yu L, Cao Z, Wang Y, Zhu C, Li Y, Yin J, Ma Z, He X, Zhang Y, Huang W, Guan Y, Chen Y, Li X, Chen X.
J Pharm Anal. 2024 Dec;14(12):101105. doi: 10.1016/j.jpha.2024.101105. Epub 2024 Sep 19.
 
Ganoderma pfeifferi Bres. and Ganoderma resinaceum Boud. as Potential Therapeutic Agents: A Comparative Study on Antiproliferative and Lipid-Lowering Properties.
Rašeta M, Kebert M, Mišković J, Kostić S, Kaišarević S, Stilinović N, Vukmirović S, Karaman M.
J Fungi (Basel). 2024 Jul 19;10(7):501. doi: 10.3390/jof10070501.
 
The acetylation of Ganoderma applanatum polysaccharides on ameliorating T2DM-induced hepatic and colonic injuries by modulating the Nrf2/keap1-TLR4/NFkappaB-Bax/Bcl-2 pathways.
Zhang Y, Li X, Xu S, Li J, Shi L, Wang Z, Chen P, Jia L, Zhang J.
Int J Biol Macromol. 2025 Mar;294:140055. doi: 10.1016/j.ijbiomac.2025.140055. Epub 2025 Jan 17.
 
Influence and underlying mechanism of soluble dietary fiber derived from Ganoderma Lucidum-fermented sweet potato residue on the physicochemical-digestive characteristics of wheat starch.
Cen Q, Fan J, Hui F, Hu W, Yu S, Liu M, Shi T, Ren Y, Zeng X, Qin L.
Int J Biol Macromol. 2025 Apr 2;309(Pt 4):142801. doi: 10.1016/j.ijbiomac.2025.142801. Online ahead of print.
 
Ultrasound combined mechanical wall-breaking extraction of new Ganoderma leucocontextum polysaccharides and their application as a structural and functional improver in set fat-free goat yogurt production.
Li J, Miao Y, Guo C, Tang Y, Xin S, Fan Z, Su Y, Li Q.
Food Chem. 2025 Mar 15;468:142374. doi: 10.1016/j.foodchem.2024.142374. Epub 2024 Dec 6.
 
Resinacein S, a novel triterpenoid from functional mushroom Ganoderma resinaceum, curbs obesity by regulating thermogenesis and energy metabolism.
Wei G, Shen FJ, Liu JL, Zhao JH, Xie RR, Lu J, Zhang CY, Wang Y, Shi TT, Yang FY, Chen SQ, Huang YJ, Yang JK.
J Food Sci. 2025 Apr;90(4):e70161. doi: 10.1111/1750-3841.70161.

A Comprehensive Review on the Chemical Composition, Pharmacology and Clinical Applications of Ganoderma.
Liu C, Song X, Li Y, Ding C, Li X, Dan L, Xu H, Zhang D.
Am J Chin Med. 2023;51(8):1983-2040. doi: 10.1142/S0192415X23500878. Epub 2023 Oct 31.
 
The Medicinal Mushroom Ganoderma neo-japonicum (Agaricomycetes) Polysaccharide Extract Prevents Obesity-Induced Diabetes in C57BL/6J Mice.
Subramaniam S, Ong KC, Sabaratnam V, Chua KH, Kuppusamy UR.
Int J Med Mushrooms. 2023;25(4):27-42. doi: 10.1615/IntJMedMushrooms.2023047595.
 
Exploring Edible Mushrooms for Diabetes: Unveiling Their Role in Prevention and Treatment.
Shamim MZ, Mishra AK, Kausar T, Mahanta S, Sarma B, Kumar V, Mishra PK, Panda J, Baek KH, Mohanta YK.
Molecules. 2023 Mar 21;28(6):2837. doi: 10.3390/molecules28062837.
 
Toxicogenic effects of the mushroom Ganoderma lucidum on human liver and kidney tumor cells and peripheral blood lymphocytes.
Antunes de Mendonça DE, Franco de Godoy MA, Lucredi NC, Comar JF, Almeida IV, Pimenta Vicentini VE.
J Ethnopharmacol. 2023 May 10;307:116226. doi: 10.1016/j.jep.2023.116226. Epub 2023 Feb 4.
 
The chemical profiling and assessment of antioxidative, antidiabetic and antineurodegenerative potential of Kombucha fermented Camellia sinensis, Coffea arabica and Ganoderma lucidum extracts.
Pavlović MO, Stajić M, Gašić U, Duletić-Laušević S, Ćilerdžić J.
Food Funct. 2023 Jan 3;14(1):262-276. doi: 10.1039/d2fo02979k.
 
A Ganoderma lucidum polysaccharide F31 alleviates hyperglycemia through kidney protection and adipocyte apoptosis.
Jiao J, Yong T, Huang L, Chen S, Xiao C, Wu Q, Hu H, Xie Y, Li X, Liu Y, Cai M, Zhang R, Xie T, Liu R.
Int J Biol Macromol. 2023 Jan 31;226:1178-1191. doi: 10.1016/j.ijbiomac.2022.11.231. Epub 2022 Nov 25.
 
Christensenella regulated by Huang-Qi-Ling-Hua-San is a key factor by which to improve type 2 diabetes.
Pan T, Zheng S, Zheng W, Shi C, Ning K, Zhang Q, Xie Y, Xiang H, Xie Q.
Front Microbiol. 2022 Oct 12;13:1022403. doi: 10.3389/fmicb.2022.1022403. eCollection 2022.
 
Bioactive Compounds from Medicinal Mushrooms.
Zhang J, Feng N, Liu Y, Zhang H, Yang Y, Liu L, Feng J.
Adv Biochem Eng Biotechnol. 2023;184:219-268. doi: 10.1007/10_2022_202.
 
Ganoderma lucidum: Unutilized natural medicine and promising future solution to emerging diseases in Africa.
Oke MA, Afolabi FJ, Oyeleke OO, Kilani TA, Adeosun AR, Olanbiwoninu AA, Adebayo EA.
Front Pharmacol. 2022 Aug 22;13:952027. doi: 10.3389/fphar.2022.952027. eCollection 2022.
 
Antidiabetic lanostane triterpenoids from the fruiting bodies of Ganoderma weberianum.
Yang L, Kong DX, Xiao N, Ma QY, Xie QY, Guo JC, Ying Deng C, Ma HX, Hua Y, Dai HF, Zhao YX.
Bioorg Chem. 2022 Oct;127:106025. doi: 10.1016/j.bioorg.2022.106025. Epub 2022 Jul 13.
 
Biosynthesis, Gene Expression, and Pharmacological Properties of Triterpenoids of Ganoderma Species (Agaricomycetes): A Review.
Angulo-Sanchez LT, López-Peña D, Torres-Moreno H, Gutiérrez A, Gaitán-Hernández R, Esqueda M.
Int J Med Mushrooms. 2022;24(6):1-17. doi: 10.1615/IntJMedMushrooms.2022044016.
 
Balancing adipocyte production and lipid metabolism to treat obesity-induced diabetes with a novel proteoglycan from Ganoderma lucidum.
Wang Y, Yu F, Zheng X, Li J, Zhang Z, Zhang Q, Chen J, He Y, Yang H, Zhou P.
Lipids Health Dis. 2023 Aug 8;22(1):120. doi: 10.1186/s12944-023-01880-6.
 
Effect of the Lingzi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) on Hyperglycemia and Dyslipidemia with Experimental Metabolic Syndrome.
Petryn TS, Nagalievska MR, Wasser SP, Sybirna NO.
Int J Med Mushrooms. 2023;25(5):17-30. doi: 10.1615/IntJMedMushrooms.2023047834.
 
Exploring the Potential Medicinal Benefits of Ganoderma lucidum: From Metabolic Disorders to Coronavirus Infections.
Ekiz E, Oz E, Abd El-Aty AM, Proestos C, Brennan C, Zeng M, Tomasevic I, Elobeid T, Çadırcı K, Bayrak M, Oz F.
Foods. 2023 Apr 3;12(7):1512. doi: 10.3390/foods12071512.
 
A proteoglycan isolated from Ganoderma lucidum attenuates diabetic kidney disease by inhibiting oxidative stress-induced renal fibrosis both in vitro and in vivo.
Pan Y, Zhang Y, Li J, Zhang Z, He Y, Zhao Q, Yang H, Zhou P.
J Ethnopharmacol. 2023 Jun 28;310:116405. doi: 10.1016/j.jep.2023.116405. Epub 2023 Mar 24.
 
Ganoderma lucidum polysaccharide peptide alleviates hyperuricemia by regulating adenosine deaminase and urate transporters.
Lin S, Meng J, Li F, Yu H, Lin D, Lin S, Li M, Zhou H, Yang B.
Food Funct. 2022 Dec 13;13(24):12619-12631. doi: 10.1039/d2fo02431d.
 
Bioreactor-grown exo- and endo-beta-glucan from Malaysian Ganoderma lucidum: An in vitro and in vivo study for potential antidiabetic treatment.
Abdullah NR, Mohd Nasir MH, Azizan NH, Wan-Mohtar WAAQI, Sharif F.
Front Bioeng Biotechnol. 2022 Aug 25;10:960320. doi: 10.3389/fbioe.2022.960320. eCollection 2022.
 
Organic chromium derived from the chelation of Ganoderma lucidum polysaccharide and chromium (III) alleviates metabolic syndromes and intestinal microbiota dysbiosis induced by high-fat and high-fructose diet.
Lv XC, Wu Q, Yuan YJ, Li L, Guo WL, Lin XB, Huang ZR, Rao PF, Ai LZ, Ni L.
Int J Biol Macromol. 2022 Oct 31;219:964-979. doi: 10.1016/j.ijbiomac.2022.07.211. Epub 2022 Aug 6.
 
The Gut Mycobiome Characterization of Gestational Diabetes Mellitus and Its Association With Dietary Intervention.
Wu N, Mo H, Mu Q, Liu P, Liu G, Yu W.
Front Microbiol. 2022 Jun 15;13:892859. doi: 10.3389/fmicb.2022.892859. eCollection 2022.
 
Ganoderma lucidum Modulates Glucose, Lipid Peroxidation and Hepatic Metabolism in Streptozotocin-Induced Diabetic Pregnant Rats.
Viroel FJM, Laurino LF, Caetano ÉLA, Jozala AF, Spim SRV, Pickler TB, Sercundes MK, Gomes MC, Hataka A, Grotto D, Gerenutti M.
Antioxidants (Basel). 2022 May 24;11(6):1035. doi: 10.3390/antiox11061035.
 
UPLC-ESI-MS/MS-based widely targeted metabolomics reveals differences in metabolite composition among four Ganoderma species.
Wei-Ye L, Hong-Bo G, Rui-Heng Y, Ai-Guo X, Jia-Chen Z, Zhao-Qian Y, Wen-Jun H, Xiao-Dan Y.
Front Nutr. 2024 Mar 18;11:1335538. doi: 10.3389/fnut.2024.1335538. eCollection 2024.
 
Role of Qufeng Tongqiao Prescription in the protection of cerebral ischemia and associated molecular network mechanism.
Bai X, Wang S, Li N, Xu M, Chen JL, Qian YP, Wang TH.
Chem Biol Drug Des. 2024 Mar;103(3):e14475. doi: 10.1111/cbdd.14475.
 
Ganoderma lucidum: Insight into antimicrobial and antioxidant properties with development of secondary metabolites.
Ahmad MF, A Alsayegh A, Ahmad FA, Akhtar MS, Alavudeen SS, Bantun F, Wahab S, Ahmed A, Ali M, Elbendary EY, Raposo A, Kambal N, H Abdelrahman M.
Heliyon. 2024 Feb 4;10(3):e25607. doi: 10.1016/j.heliyon.2024.e25607. eCollection 2024 Feb 15.
 
Ganoderma lucidum polysaccharide hydrogel accelerates diabetic wound healing by regulating macrophage polarization.
Li F, Liu T, Liu X, Han C, Li L, Zhang Q, Sui X.
Int J Biol Macromol. 2024 Mar;260(Pt 2):129682. doi: 10.1016/j.ijbiomac.2024.129682. Epub 2024 Jan 22.
 
Pharmacological Activities and Safety of Ganoderma lucidum Spores: A Systematic Review.
Thuy NHL, Tu VL, Thu LNA, Giang TT, Huyen DTK, Loc DH, Tam DNH, Phat NT, Huynh HH, Truyen TTTT, Nguyen QH, Do U, Nguyen D, Dat TV, Minh LHN.
Cureus. 2023 Sep 2;15(9):e44574. doi: 10.7759/cureus.44574. eCollection 2023 Sep.
 
Proteoglycan Extracted from Ganoderma lucidum Ameliorated Diabetes-Induced Muscle Atrophy via the AMPK/SIRT1 Pathway In Vivo and In Vitro.
Li J, Zhang Y, Yu F, Pan Y, Zhang Z, He Y, Yang H, Zhou P.
ACS Omega. 2023 Aug 8;8(33):30359-30373. doi: 10.1021/acsomega.3c03513. eCollection 2023 Aug 22.
 
Mushroom-Related Ethnomycological, Ethnomedical, and Socio-Economic Practices in Nigeria.
Ndifon EM, Emeka CPO, Inyang P.
Int J Med Mushrooms. 2023;25(8):33-42. doi: 10.1615/IntJMedMushrooms.2023049043.
 
Effects of a Ganoderma lucidum Proteoglycan on Type 2 Diabetic Rats and the Recovery of Rat Pancreatic Islets.
Yu F, Teng Y, Li J, Yang S, Zhang Z, He Y, Yang H, Ding CF, Zhou P.
ACS Omega. 2023 May 5;8(19):17304-17316. doi: 10.1021/acsomega.3c02200. eCollection 2023 May 16.
 
LC/MS analysis of mushrooms provided new insights into dietary management of diabetes mellitus in rats.
Hussein A, Ghonimy A, Jiang H, Qin G, El-Ashram S, Hussein S, Abd El-Razek I, El-Afifi T, Farouk MH.
Food Sci Nutr. 2023 Jan 27;11(5):2321-2335. doi: 10.1002/fsn3.3236. eCollection 2023 May.
 
Spore Oil-Functionalized Selenium Nanoparticles Protect Pancreatic Beta Cells from Palmitic Acid-Induced Apoptosis via Inhibition of Oxidative Stress-Mediated Apoptotic Pathways.
Zhou S, Zhu H, Xiong P, Shi L, Bai W, Li X.
Antioxidants (Basel). 2023 Mar 30;12(4):840. doi: 10.3390/antiox12040840.
 
Novel Ganoderma triterpenoid saponins from the biotransformation-guided purification of a commercial Ganoderma extract.
Ding HY, Wang TY, Wu JY, Zhang YR, Chang TS.
J Biosci Bioeng. 2023 May;135(5):402-410. doi: 10.1016/j.jbiosc.2023.02.004. Epub 2023 Mar 6.
 
Network pharmacology-based analysis of Resinacein S against non-alcoholic fatty liver disease by modulating lipid metabolism.
Mao FF, Gao SS, Huang YJ, Zhou N, Feng JK, Liu ZH, Zhang YQ, Yuan LY, Wei G, Cheng SQ.
Front Nutr. 2023 Feb 14;10:1076569. doi: 10.3389/fnut.2023.1076569. eCollection 2023.
 
A Review on the Sources, Structures, and Pharmacological Activities of Lucidenic Acids.
Zheng C, Rangsinth P, Shiu PHT, Wang W, Li R, Li J, Kwan YW, Leung GPH.
Molecules. 2023 Feb 12;28(4):1756. doi: 10.3390/molecules28041756.
 
Inhibitory effect of plant essential oils on α-glucosidase.
You Z, Li Y, Zhang K, Zheng X, Wong VKW, Liu W.
Food Sci Biotechnol. 2022 Aug 9;31(12):1593-1602. doi: 10.1007/s10068-022-01145-5. eCollection 2022 Nov.
 
Activity fingerprinting of polysaccharides on oral, gut, pancreas and lung microbiota in diabetic rats.
Wu RT, Wang LF, Yao YF, Sang T, Wu QL, Fu WW, Wan M, Li WJ.
Biomed Pharmacother. 2022 Nov;155:113681. doi: 10.1016/j.biopha.2022.113681. Epub 2022 Sep 12.
 
Ganoderma spp. polysaccharides are potential prebiotics: a review.
Zheng M, Pi X, Li H, Cheng S, Su Y, Zhang Y, Man C, Jiang Y.
Crit Rev Food Sci Nutr. 2024;64(4):909-927. doi: 10.1080/10408398.2022.2110035. Epub 2022 Aug 18.
 
Ganoderma lucidum polysaccharide ameliorated diabetes mellitus-induced erectile dysfunction in rats by regulating fibrosis and the NOS/ERK/JNK pathway.
Yao X, Yuan Y, Jing T, Ye S, Wang S, Xia D.
Transl Androl Urol. 2022 Jul;11(7):982-995. doi: 10.21037/tau-22-428.
 
Mushrooms as Potential Sources of Active Metabolites and Medicines.
Bhambri A, Srivastava M, Mahale VG, Mahale S, Karn SK.
Front Microbiol. 2022 Apr 26;13:837266. doi: 10.3389/fmicb.2022.837266. eCollection 2022.

The Pharmacological Rationales and Molecular Mechanisms of Ganoderma lucidum Polysaccharides for the Therapeutic Applications of Multiple Diseases.
Luo H, Tan D, Peng B, Zhang S, Vong CT, Yang Z, Wang Y, Lin Z.
Am J Chin Med. 2022;50(1):53-90. doi: 10.1142/S0192415X22500033. Epub 2021 Dec 28.
 
A polysaccharide isolated from Ganoderma lucidum ameliorates hyperglycemia through modulating gut microbiota in type 2 diabetic mice.
Shao W, Xiao C, Yong T, Zhang Y, Hu H, Xie T, Liu R, Huang L, Li X, Xie Y, Zhang J, Chen S, Cai M, Chen D, Liu Y, Gao X, Wu Q.
Int J Biol Macromol. 2022 Feb 1;197:23-38. doi: 10.1016/j.ijbiomac.2021.12.034. Epub 2021 Dec 15.
 
The thermodynamic and kinetic mechanisms of a Ganoderma lucidum proteoglycan inhibiting hIAPP amyloidosis.
Yu F, Teng Y, Yang S, He Y, Zhang Z, Yang H, Ding CF, Zhou P.
Biophys Chem. 2022 Jan;280:106702. doi: 10.1016/j.bpc.2021.106702. Epub 2021 Oct 30.
 
Triterpenoids and meroterpenoids with α-glucosidase inhibitory activities from the fruiting bodies of Ganoderma australe.
Guo JC, Yang L, Ma QY, Ge YZ, Kong FD, Zhou LM, Fei Zhang, Xie QY, Yu ZF, Dai HF, Zhao YX.
Bioorg Chem. 2021 Dec;117:105448. doi: 10.1016/j.bioorg.2021.105448. Epub 2021 Oct 22.
 
The beneficial effects of Ganoderma lucidum on cardiovascular and metabolic disease risk.
Chan SW, Tomlinson B, Chan P, Lam CWK.
Pharm Biol. 2021 Dec;59(1):1161-1171. doi: 10.1080/13880209.2021.1969413.
 
Health-Promoting of Polysaccharides Extracted from Ganoderma lucidum.
Seweryn E, Ziała A, Gamian A.
Nutrients. 2021 Aug 7;13(8):2725. doi: 10.3390/nu13082725.
 
Manipulations of glucose/lipid metabolism and gut microbiota of resistant starch encapsulated Ganoderma lucidum spores in T2DM rats.
Jiang Y, Zhang N, Zhou Y, Zhou Z, Bai Y, Strappe P, Blanchard C.
Food Sci Biotechnol. 2021 Apr 24;30(5):755-764. doi: 10.1007/s10068-021-00908-w. eCollection 2021 May.
 
Evaluation of the hypoglycaemic and antioxidant effects of submerged Ganoderma lucidum cultures in type 2 diabetic rats.
Huang CH, Lin WK, Chang SH, Tsai GJ.
Mycology. 2020 Mar 1;12(2):82-93. doi: 10.1080/21501203.2020.1733119.
 
Effects and Mechanism of Ganoderma lucidum Polysaccharides in the Treatment of Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats.
Hu Y, Wang SX, Wu FY, Wu KJ, Shi RP, Qin LH, Lu CF, Wang SQ, Wang FF, Zhou S.
Biomed Res Int. 2022 Mar 8;2022:4314415. doi: 10.1155/2022/4314415. eCollection 2022.
 
Antioxidation of a proteoglycan from Ganoderma lucidum protects pancreatic β-cells against oxidative stress-induced apoptosis in vitro and in vivo.
Pan Y, Yuan S, Teng Y, Zhang Z, He Y, Zhang Y, Liang H, Wu X, Li J, Yang H, Zhou P.
Int J Biol Macromol. 2022 Mar 1;200:470-486. doi: 10.1016/j.ijbiomac.2022.01.044. Epub 2022 Jan 19.
 
Self-nanoemulsifying composition containing curcumin, quercetin, Ganoderma lucidum extract powder and probiotics for effective treatment of type 2 diabetes mellitus in streptozotocin induced rats.
Khursheed R, Singh SK, Kumar B, Wadhwa S, Gulati M, A A, Awasthi A, Vishwas S, Kaur J, Corrie L, K R A, Kumar R, Jha NK, Gupta PK, Zacconi F, Dua K, Chitranshi N, Mustafa G, Kumar A.
Int J Pharm. 2022 Jan 25;612:121306. doi: 10.1016/j.ijpharm.2021.121306. Epub 2021 Nov 20.
 
Ganoderma applanatum mushroom provides new insights into the management of diabetes mellitus, hyperlipidemia, and hepatic degeneration: A comprehensive analysis.
Hossain MS, Barua A, Tanim MAH, Hasan MS, Islam MJ, Hossain MR, Emon NU, Hossen SMM.
Food Sci Nutr. 2021 Jun 24;9(8):4364-4374. doi: 10.1002/fsn3.2407. eCollection 2021 Aug.
 
Significant effects of Ganoderma lucidum polysaccharide on lipid metabolism in diabetes may be associated with the activation of the FAM3C-HSF1-CAM signaling pathway.
Pan R, Lou J, Wei L.
Exp Ther Med. 2021 Aug;22(2):820. doi: 10.3892/etm.2021.10252. Epub 2021 Jun 2.
 
Anti-diabetic Effects of Macronutrients via Modulation of Angiogenesis: A Comprehensive Review on Carbohydrates and Proteins.
Khosravifar M, Sajadimajd S, Bahramic G.
Curr Mol Med. 2022 Mar 21. doi: 10.2174/1566524022666220321125548. Online ahead of print.
 
Inhibition on α-Glucosidase Activity and Non-Enzymatic Glycation by an Anti-Oxidative Proteoglycan from Ganoderma lucidum.
Zhang Y, Pan Y, Li J, Zhang Z, He Y, Yang H, Zhou P.
Molecules. 2022 Feb 22;27(5):1457. doi: 10.3390/molecules27051457.
 
Sexual Crossing, Chromosome-Level Genome Sequences, and Comparative Genomic Analyses for the Medicinal Mushroom Taiwanofungus Camphoratus (Syn. Antrodia Cinnamomea, Antrodia Camphorata).
Chen CL, Li WC, Chuang YC, Liu HC, Huang CH, Lo KY, Chen CY, Chang FM, Chang GA, Lin YL, Yang WD, Su CH, Yeh TM, Wang TF.
Microbiol Spectr. 2022 Feb 23;10(1):e0203221. doi: 10.1128/spectrum.02032-21. Epub 2022 Feb 23.
 
Meroterpenoids From Ganoderma lucidum Mushrooms and Their Biological Roles in Insulin Resistance and Triple-Negative Breast Cancer.
Zhang JJ, Wang DW, Cai D, Lu Q, Cheng YX.
Front Chem. 2021 Nov 3;9:772740. doi: 10.3389/fchem.2021.772740. eCollection 2021.
 
Interaction and Inhibition of a Ganoderma lucidum Proteoglycan on PTP1B Activity for Anti-diabetes.
Yu F, Wang Y, Teng Y, Yang S, He Y, Zhang Z, Yang H, Ding CF, Zhou P.
ACS Omega. 2021 Oct 27;6(44):29804-29813. doi: 10.1021/acsomega.1c04244. eCollection 2021 Nov 9.
 
Study of the Lipolysis Effect of Nanoliposome-Encapsulated Ganoderma lucidum Protein Hydrolysates on Adipocyte Cells Using Proteomics Approach.
Krobthong S, Yingchutrakul Y, Visessanguan W, Mahatnirunkul T, Samutrtai P, Chaichana C, Papan P, Choowongkomon K.
Foods. 2021 Sep 12;10(9):2157. doi: 10.3390/foods10092157.
 
Antidyslipidemic Potential of Water-Soluble Polysaccharides of Ganoderma applanatum in MACAPOS-2-Induced Obese Rats.
Mfopa A, Mediesse FK, Mvongo C, Nkoubatchoundjwen S, Lum AA, Sobngwi E, Kamgang R, Boudjeko T.
Evid Based Complement Alternat Med. 2021 Aug 18;2021:2452057. doi: 10.1155/2021/2452057. eCollection 2021.
 
Ganoderma lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties.
Ahmad R, Riaz M, Khan A, Aljamea A, Algheryafi M, Sewaket D, Alqathama A.
Phytother Res. 2021 Nov;35(11):6030-6062. doi: 10.1002/ptr.7215. Epub 2021 Aug 19.
 
A network pharmacology analysis on drug-like compounds from Ganoderma lucidum for alleviation of atherosclerosis.
Oh KK, Adnan M, Cho DH.
J Food Biochem. 2021 Sep;45(9):e13906. doi: 10.1111/jfbc.13906. Epub 2021 Aug 18.
 
Ganoderma lucidum ameliorates the diabetic nephropathy via down-regulatory effect on TGFβ-1 and TLR-4/NFκB signalling pathways.
Hassan HM, Mahran YF, Ghanim AMH.
J Pharm Pharmacol. 2021 Aug 12;73(9):1250-1261. doi: 10.1093/jpp/rgab058.
 
In vitro and in silico anticancer evaluation of a medicinal mushroom, Ganoderma neo-japonicum Imazeki, against human colonic carcinoma cells.
Lau MF, Chua KH, Sabaratnam V, Kuppusamy UR.
Biotechnol Appl Biochem. 2021 Aug;68(4):902-917. doi: 10.1002/bab.2013. Epub 2020 Sep 13.
 
Ganoderma lucidum Extract Reduces Insulin Resistance by Enhancing AMPK Activation in High-Fat Diet-Induced Obese Mice.
Lee HA, Cho JH, Afinanisa Q, An GH, Han JG, Kang HJ, Choi SH, Seong HA.
Nutrients. 2020 Oct 30;12(11):3338. doi: 10.3390/nu12113338.
 
Optimization of antioxidant, anti-diabetic, and anti-inflammatory activities and ganoderic acid content of differentially dried Ganoderma lucidum using response surface methodology.
Ryu DH, Cho JY, Sadiq NB, Kim JC, Lee B, Hamayun M, Lee TS, Kim HS, Park SH, Nho CW, Kim HY.
Food Chem. 2021 Jan 15;335:127645. doi: 10.1016/j.foodchem.2020.127645. Epub 2020 Jul 25.
 
Molecular mechanisms of bioactive polysaccharides from Ganoderma lucidum (Lingzhi), a review.
Lu J, He R, Sun P, Zhang F, Linhardt RJ, Zhang A.
Int J Biol Macromol. 2020 May 1;150:765-774. doi: 10.1016/j.ijbiomac.2020.02.035. Epub 2020 Feb 6.
 
Kinetics Analysis of the Inhibitory Effects of Alpha-Glucosidase and Identification of Compounds from Ganoderma lipsiense Mycelium.
Costa TM, Mayer DA, Siebert DA, Micke GA, Alberton MD, Tavares LBB, de Oliveira D.
Appl Biochem Biotechnol. 2020 Jul;191(3):996-1009. doi: 10.1007/s12010-020-03239-4. Epub 2020 Jan 17.
 
Effect of Cultured Substrates on the Chemical Composition and Biological Activities of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes).
Song T, Zhang Z, Liu S, Chen J, Cai W.
Int J Med Mushrooms. 2020;22(12):1183-1190. doi: 10.1615/IntJMedMushrooms.2020037133.
 
Medicinal Mushrooms for Treatment of Type 2 Diabetes: An Update on Clinical Trials.
Lindequist U, Haertel B.
Int J Med Mushrooms. 2020;22(9):845-854. doi: 10.1615/IntJMedMushrooms.2020035863.
 
The Medicinal Mushroom Ganoderma neo-japonicum (Agaricomycetes) from Malaysia: Nutritional Composition and Potentiation of Insulin-Like Activity in 3T3-L1 Cells.
Subramaniam S, Sabaratnam V, Heng CK, Kuppusamy UR.
Int J Med Mushrooms. 2020;22(1):65-78. doi: 10.1615/IntJMedMushrooms.2020033250.
 
Intake of Ganoderma lucidum polysaccharides reverses the disturbed gut microbiota and metabolism in type 2 diabetic rats.
Chen M, Xiao D, Liu W, Song Y, Zou B, Li L, Li P, Cai Y, Liu D, Liao Q, Xie Z.
Int J Biol Macromol. 2020 Jul 15;155:890-902. doi: 10.1016/j.ijbiomac.2019.11.047. Epub 2019 Nov 9.
 
Effects of Ganoderma lucidum and Ceratonia siliqua on blood glucose, lipid profile, and body composition in women with fibromyalgia.
Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MÁ, Gusi N, Collado-Mateo D.
Nutr Hosp. 2021 Feb 23;38(1):139-145. doi: 10.20960/nh.03190.
 
Effects of redox interference on the pancreatic mitochondria and the abnormal blood glucose.
Xie F, Wu M, Lai B, Halim M, Liu S, Shi D.
Free Radic Res. 2021 Jan 4:1-12. doi: 10.1080/10715762.2020.1866180. Online ahead of print.
 
Effect and Mechanism of Ganoderma lucidum Spores on Alleviation of Diabetic Cardiomyopathy in a Pilot in vivo Study.
Shaher F, Wang S, Qiu H, Hu Y, Zhang Y, Wang W, Al-Ward H, Abdulghani MAM, Baldi S, Zhou S.
Diabetes Metab Syndr Obes. 2020 Dec 7;13:4809-4822. doi: 10.2147/DMSO.S281527. eCollection 2020.
 
Recombinant ling zhi-8 enhances Tregs function to restore glycemic control in streptozocin-induced diabetic rats.
Xiao H, Fang Z, He X, Ding P, Cao Y, Chan S, Hou S, Liang J.
J Pharm Pharmacol. 2020 Dec;72(12):1946-1955. doi: 10.1111/jphp.13360. Epub 2020 Aug 17.
 
Meroterpenoids With Protein Tyrosine Phosphatase 1B Inhibitory Activities From the Fruiting Bodies of Ganoderma ahmadii.
Guo J, Kong F, Ma Q, Xie Q, Zhang R, Dai H, Wu Y, Zhao Y.
Front Chem. 2020 Apr 16;8:279. doi: 10.3389/fchem.2020.00279. eCollection 2020.
 
Ganoderma lucidum ameliorates the diabetic nephropathy via down-regulatory effect on TGFbeta-1 and TLR-4/NFkappaB signalling pathways.
Hassan HM, Mahran YF, Ghanim AMH.
J Pharm Pharmacol. 2021 Apr 13:rgab058. doi: 10.1093/jpp/rgab058. Online ahead of print.
 
Pancreatic cancer cell apoptosis is induced by a proteoglycan extracted from Ganoderma lucidum.
Wu X, Jiang L, Zhang Z, He Y, Teng Y, Li J, Yuan S, Pan Y, Liang H, Yang H, Zhou P.
Oncol Lett. 2021 Jan;21(1):34. doi: 10.3892/ol.2020.12295. Epub 2020 Nov 12.
 
In vitro and in silico anticancer evaluation of a medicinal mushroom, Ganoderma neo-japonicum Imazeki, against human colonic carcinoma cells.
Lau MF, Chua KH, Sabaratnam V, Kuppusamy UR.
Biotechnol Appl Biochem. 2020 Aug 28. doi: 10.1002/bab.2013. Online ahead of print.
 
A proteoglycan extract from Ganoderma Lucidum protects pancreatic beta-cells against STZ-induced apoptosis.
Liang H, Pan Y, Teng Y, Yuan S, Wu X, Yang H, Zhou P.
Biosci Biotechnol Biochem. 2020 Dec;84(12):2491-2498. doi: 10.1080/09168451.2020.1805718. Epub 2020 Aug 16.
 
Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review.
Shaher F, Qiu H, Wang S, Hu Y, Wang W, Zhang Y, Wei Y, Al-Ward H, Abdulghani MAM, Alenezi SK, Baldi S, Zhou S.
Biomed Res Int. 2020 Jul 25;2020:7136075. doi: 10.1155/2020/7136075. eCollection 2020.
 
Triterpenoids from functional mushroom Ganoderma resinaceum and the novel role of Resinacein S in enhancing the activity of brown/beige adipocytes.
Huang Y, Wei G, Peng X, Hu G, Su H, Liu J, Chen X, Qiu M.
Food Res Int. 2020 Oct;136:109303. doi: 10.1016/j.foodres.2020.109303. Epub 2020 May 11.
 
Recombinant Lactococcus lactis Expressing Ling Zhi 8 Protein Ameliorates Nonalcoholic Fatty Liver and Early Atherogenesis in Cholesterol-Fed Rabbits.
Lee MF, Chiang CH, Lin SJ, Song PP, Liu HC, Wu TJ, Lin WW.
Biomed Res Int. 2020 Jan 27;2020:3495682. doi: 10.1155/2020/3495682. eCollection 2020.
 
Medicinal Mushrooms for Treatment of Type 2 Diabetes: An Update on Clinical Trials.
Lindequist U, Haertel B.
Int J Med Mushrooms. 2020;22(9):845-854. doi: 10.1615/IntJMedMushrooms.2020035863.
 
Preventive and therapeutic effect of Ganoderma lucidum on kidney injuries and diseases.
Geng X, Zhong D, Su L, Lin Z, Yang B.
Adv Pharmacol. 2020;87:257-276. doi: 10.1016/bs.apha.2019.10.003. Epub 2019 Nov 20.
 
Submerged cultivation of medicinal mushroom in hydrolysate of ligno-cellulosic material.
Kausar S, Zia S, Khan FS, Nadeem Z.
Pak J Pharm Sci. 2019 Nov;32(6(Supplementary)):2835-2841.
 
Antioxidative and Free Radical Scavenging Activity of Ganoderma (Lingzhi).
Lin Z, Deng A.
Adv Exp Med Biol. 2019;1182:271-297. doi: 10.1007/978-981-32-9421-9_12. Review.
 
Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Diabetes.
Liu Q, Tie L.
Adv Exp Med Biol. 2019;1182:201-215. doi: 10.1007/978-981-32-9421-9_8. Review.
 
Inhibitory Effect of Five Ganoderma Species (Agaricomycetes) against Key Digestive Enzymes Related to Type 2 Diabetes Mellitus.
Chen SD, Yong TQ, Zhang YF, Hu HP, Xie YZ.
Int J Med Mushrooms. 2019;21(7):703-711. doi: 10.1615/IntJMedMushrooms.v21.i7.70.
 
Effects of a Ganoderma atrum polysaccharide against pancreatic damage in streptozotocin-induced diabetic mice.
Li L, Li RC, Song YH, Wu WY, Yin SH, Fu WW, Wu RT, Li W.
Food Funct. 2019 Nov 1;10(11):7227-7238. doi: 10.1039/c9fo01990a. Epub 2019 Oct 16.
 
Preparation of Ganoderma lucidum polysaccharide‑chromium (III) complex and its hypoglycemic and hypolipidemic activities in high-fat and high-fructose diet-induced pre-diabetic mice.
Li L, Xu JX, Cao YJ, Lin YC, Guo WL, Liu JY, Bai WD, Zhang YY, Ni L, Liu B, Rao PF, Lv XC.
Int J Biol Macromol. 2019 Nov 1;140:782-793. doi: 10.1016/j.ijbiomac.2019.08.072. Epub 2019 Aug 8.
 
Mass Spectrometry-Based Untargeted Metabolomics and α-Glucosidase Inhibitory Activity of Lingzhi (Ganoderma lingzhi) During the Developmental Stages.
Satria D, Tamrakar S, Suhara H, Kaneko S, Shimizu K.
Molecules. 2019 May 29;24(11). pii: E2044. doi: 10.3390/molecules24112044.
 
Ganoderma lucidum polysaccharide used for treating physical frailty in China.
Zeng P, Chen Y, Zhang L, Xing M.
Prog Mol Biol Transl Sci. 2019;163:179-219. doi: 10.1016/bs.pmbts.2019.02.009. Epub 2019 Mar 26. Review.
 
[Study on chemical constituents from fruiting bodies of Ganoderma australe].
Ge YZ, Ma QY, Kong FD, Xie QY, An CL, Yu ZF, Zhao YX.
Zhongguo Zhong Yao Za Zhi. 2019 Feb;44(3):489-494. doi: 10.19540/j.cnki.cjcmm.20181121.004. Chinese. 
 
Ganoderma Lucidum Polysaccharides Ameliorates Hepatic Steatosis and Oxidative Stress in db/db Mice via Targeting Nuclear Factor E2 (Erythroid-Derived 2)-Related Factor-2/Heme Oxygenase-1 (HO-1) Pathway.
Li HN, Zhao LL, Zhou DY, Chen DQ.
Med Sci Monit. 2020 Apr 4;26:e921905. doi: 10.12659/MSM.921905.
 
Kinetics Analysis of the Inhibitory Effects of Alpha-Glucosidase and Identification of Compounds from Ganoderma lipsiense Mycelium.
Costa TM, Mayer DA, Siebert DA, Micke GA, Alberton MD, Tavares LBB, de Oliveira D.
Appl Biochem Biotechnol. 2020 Jan 17. doi: 10.1007/s12010-020-03239-4. [Epub ahead of print]
 
Biotransformation of mogrosides from Siraitia grosvenorii by Ganoderma lucidum mycelium and the purification of mogroside III E by macroporous resins.
Chiu CH, Wang R, Zhuang S, Lin PY, Lo YC, Lu TJ.
J Food Drug Anal. 2020 Jan;28(1):74-83. doi: 10.1016/j.jfda.2019.05.001. Epub 2019 May 29.
 
Intake of Ganoderma lucidum polysaccharides reverses the disturbed gut microbiota and metabolism in type 2 diabetic rats.
Chen M, Xiao D, Liu W, Song Y, Zou B, Li L, Li P, Cai Y, Liu D, Liao Q, Xie Z.
Int J Biol Macromol. 2019 Nov 9. pii: S0141-8130(19)34451-4. doi: 10.1016/j.ijbiomac.2019.11.047. 
 
Polysaccharide peptide (PsP) Ganoderma lucidum: a potential inducer for vascular repair in type 2 diabetes mellitus model.
Heriansyah T, Nurwidyaningtyas W, Sargowo D, Tjahjono CT, Wihastuti TA.
Vasc Health Risk Manag. 2019 Oct 3;15:419-427. doi: 10.2147/VHRM.S205996. eCollection 2019. Erratum in: Vasc Health Risk Manag. 2019 Nov 05;15:517. 
 
Pharmacological effects of Ganoderma lucidum extract against high-altitude stressors and its subchronic toxicity assessment.
Sharma P, Tulsawani R, Agrawal U.
J Food Biochem. 2019 Dec;43(12):e13081. doi: 10.1111/jfbc.13081. Epub 2019 Oct 14.
 
Molecular mechanisms of bioactive polysaccharides from Ganoderma lucidum (Lingzhi), a review.
Lu J, He R, Sun P, Zhang F, Linhardt RJ, Zhang A.
Int J Biol Macromol. 2020 May 1;150:765-774. doi: 10.1016/j.ijbiomac.2020.02.035. Epub 2020 Feb 6. Review.
 
Decreasing angiogenesis vasa vasorum through Lp-PLA2 and H2O2 inhibition by PSP from Ganoderma lucidum in atherosclerosis: in vivo diabetes mellitus type 2.
Wihastuti TA, Amiruddin R, Cesa FY, Alkaf AI, Setiawan M, Heriansyah T.
J Basic Clin Physiol Pharmacol. 2020 Feb 7;30(6). pii: /j/jbcpp.2019.30.issue-6/jbcpp-2019-0349/jbcpp-2019-0349.xml. doi: 10.1515/jbcpp-2019-0349.
 
Steroid sulfatase inhibiting lanostane triterpenes - Structure activity relationship and in silico insights.
Grienke U, Kaserer T, Kirchweger B, Lambrinidis G, Kandel RT, Foster PA, Schuster D, Mikros E, Rollinger JM.
Bioorg Chem. 2020 Jan;95:103495. doi: 10.1016/j.bioorg.2019.103495. Epub 2019 Dec 9.
 
Erratum: Polysaccharide Peptide (PsP) Ganoderma lucidum: A Potential Inducer For Vascular Repair In Type 2 Diabetes Mellitus Model [Corrigendum].
[No authors listed]
Vasc Health Risk Manag. 2019 Nov 5;15:517. doi: 10.2147/VHRM.S234754. eCollection 2019.
 
Production of triterpenoid compounds from Ganoderma lucidum spore powder using ultrasound-assisted extraction.
Shen SF, Zhu LF, Wu Z, Wang G, Ahmad Z, Chang MW.
Prep Biochem Biotechnol. 2020;50(3):302-315. doi: 10.1080/10826068.2019.1692218. Epub 2019 Nov 22.
 
Mushrooms of the Genus Ganoderma Used to Treat Diabetes and Insulin Resistance.
Mushrooms of the Genus Ganoderma Used to Treat Diabetes and Insulin Resistance.
Molecules. 2019 Nov 11;24(22). pii: E4075. doi: 10.3390/molecules24224075. Review.
 
Inhibitory Effect of Five Ganoderma Species (Agaricomycetes) against Key Digestive Enzymes Related to Type 2 Diabetes Mellitus.
Chen SD, Yong TQ, Zhang YF, Hu HP, Xie YZ.
nt J Med Mushrooms. 2019;21(7):703-711. doi: 10.1615/IntJMedMushrooms.v21.i7.70.
 
Determination of genotoxic and antigenotoxic effects of wild-grown Reishi mushroom (Ganoderma lucidum) using the hen's egg test for analysis of micronucleus induction.
Çelik B, Özparlak H.
Biotech Histochem. 2019 Nov;94(8):628-636. doi: 10.1080/10520295.2019.1622784. Epub 2019 Jul 8.
 
[Pharmacokinetics of ganoderic acids].
Zhang FF, Liu RM.
Zhongguo Zhong Yao Za Zhi. 2019 Mar;44(5):905-911. doi: 10.19540/j.cnki.cjcmm.20181213.002. Review. Chinese. 
 
Hypoglycemic mechanisms of Ganoderma lucidum polysaccharides F31 in db/db mice via RNA-seq and iTRAQ.
Xiao C, Wu Q, Xie Y, Tan J, Ding Y, Bai L.
Food Funct. 2018 Dec 13;9(12):6495-6507. doi: 10.1039/c8fo01656a.
 
Hypoglicemic and Hypolipedimic Effects of Ganoderma lucidum in Streptozotocin-Induced Diabetic Rats.
Bach EE, Hi EMB, Martins AMC, Nascimento PAM, Wadt NSY.
Medicines (Basel). 2018 Jul 28;5(3). pii: E78. doi: 10.3390/medicines5030078.
 
Isolation, Structural Elucidation, and α-Glucosidase Inhibitory Activities of Triterpenoid Lactones and Their Relevant Biogenetic Constituents from Ganoderma resinaceum.
Chen XQ, Lin LG, Zhao J, Chen LX, Tang YP, Luo DL, Li SP.
Molecules. 2018 Jun 8;23(6). pii: E1391. doi: 10.3390/molecules23061391.
 
Ganoderma lucidum Ameliorates Non-Alcoholic Steatosis by Upregulating Energy Metabolizing Enzymes in the Liver.
Jung S, Son H, Hwang CE, Cho KM, Park SW, Kim HJ.
J Clin Med. 2018 Jun 15;7(6). pii: E152. doi: 10.3390/jcm7060152.
 
Hypouricemic Effect of 2,5-Dihydroxyacetophenone, a Computational Screened Bioactive Compound from Ganoderma applanatum, on Hyperuricemic Mice.
Liang D, Yong T, Chen S, Xie Y, Chen D, Zhou X, Li D, Li M, Su L, Zuo D.
Int J Mol Sci. 2018 May 7;19(5). pii: E1394. doi: 10.3390/ijms19051394.
 
Effect of Ganoderma lucidum Powder on Oxidative Stability, Microbial and Sensory Properties of Emulsion Type Sausage.
Ghobadi R, Mohammadi R, Chabavizade J, Sami M.
Adv Biomed Res. 2018 Feb 16;7:24. doi: 10.4103/2277-9175.225595. eCollection 2018.
 
Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against α-glucosidase.
Chen XQ, Zhao J, Chen LX, Wang SF, Wang Y, Li SP.
Phytochemistry. 2018 May;149:103-115. doi: 10.1016/j.phytochem.2018.01.007. Epub 2018 Feb 25.
 
Hypoglycemic mechanism of a novel proteoglycan, extracted from Ganoderma lucidum, in hepatocytes.
Yang Z, Chen C, Zhao J, Xu W, He Y, Yang H, Zhou P.
Eur J Pharmacol. 2018 Feb 5;820:77-85. doi: 10.1016/j.ejphar.2017.12.020. Epub 2017 Dec 9.
 
A novel PTP1B inhibitor extracted from Ganoderma lucidum ameliorates insulin resistance by regulating IRS1-GLUT4 cascades in the insulin signaling pathway.
Yang Z, Wu F, He Y, Zhang Q, Zhang Y, Zhou G, Yang H, Zhou P.
Food Funct. 2018 Jan 24;9(1):397-406. doi: 10.1039/c7fo01489a.
 
Enzyme inhibitory, Antifungal, Antibacterial and hemolytic potential of various fractions of Colebrookia oppositifolia.
Riaz T, Abbasi MA, Rehman A, Siddiqui SZ, Shahid M, Fatima H, Ashraf M, Ejaz SA, Rasool ZG, Abbasi GH.
Pak J Pharm Sci. 2017 Jan;30(1):105-112.
 
Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus.
Vitak T, Yurkiv B, Wasser S, Nevo E, Sybirna N.
World J Diabetes. 2017 May 15;8(5):187-201. doi: 10.4239/wjd.v8.i5.187. Review.
 
Enzymatic System of Antioxidant Protection of Erythrocytes in Diabetic Rats Treated with Medicinal Mushrooms Agaricus brasiliensis and Ganoderma lucidum (Agaricomycetes).
Vitak TY, Wasser SP, Nevo E, Sybirna NO.
Int J Med Mushrooms. 2017;19(8):697-708. doi: 10.1615/IntJMedMushrooms.2017021305.
 
Functional Properties of Partially Characterized Polysaccharide from the Medicinal Mushroom Ganoderma neo-japonicum (Agaricomycetes).
Subramaniam S, Raman J, Sabaratnam V, Heng CK, Kuppusamy UR.
Int J Med Mushrooms. 2017;19(10):849-859. doi: 10.1615/IntJMedMushrooms.2017024355.
 
Partial contribution of Rho-kinase inhibition to the bioactivity of Ganoderma lingzhi and its isolated compounds: insights on discovery of natural Rho-kinase inhibitors.
Amen Y, Zhu Q, Tran HB, Afifi MS, Halim AF, Ashour A, Shimizu K.
J Nat Med. 2017 Apr;71(2):380-388. doi: 10.1007/s11418-016-1069-y. Epub 2017 Jan 10.
 
Antidiabetic activity of Ganoderma lucidum polysaccharides F31 down-regulated hepatic glucose regulatory enzymes in diabetic mice.
Xiao C, Wu Q, Zhang J, Xie Y, Cai W, Tan J.
J Ethnopharmacol. 2017 Jan 20;196:47-57. doi: 10.1016/j.jep.2016.11.044. Epub 2016 Nov 27.
 
A novel class of α-glucosidase and HMG-CoA reductase inhibitors from Ganoderma leucocontextum and the anti-diabetic properties of ganomycin I in KK-Aymice.
Wang K, Bao L, Ma K, Zhang J, Chen B, Han J, Ren J, Luo H, Liu H.
Eur J Med Chem. 2017 Feb 15;127:1035-1046. doi: 10.1016/j.ejmech.2016.11.015. Epub 2016 Nov 9.
 
Comparison of the Chemical Profiles and Antioxidant and Antidiabetic Activities of Extracts from Two Ganoderma Species (Agaricomycetes).
Tang X, Cai W, Xu B.
Int J Med Mushrooms. 2016;18(7):609-20.
 
A double-blind, randomised, placebo-controlled trial of Ganoderma lucidum for the treatment of cardiovascular risk factors of metabolic syndrome.
Klupp NL, Kiat H, Bensoussan A, Steiner GZ, Chang DH.
Sci Rep. 2016 Aug 11;6:29540. doi: 10.1038/srep29540.
 
A Polysaccharide from Ganoderma atrum Improves Liver Function in Type 2 Diabetic Rats via Antioxidant Action and Short-Chain Fatty Acids Excretion.
Zhu KX, Nie SP, Tan LH, Li C, Gong DM, Xie MY.
J Agric Food Chem. 2016 Mar 9;64(9):1938-44. doi: 10.1021/acs.jafc.5b06103. Epub 2016 Feb 29.
 
Three kinds of Ganoderma lucidum polysaccharides attenuate DDC-induced chronic pancreatitis in mice.
Li K, Yu M, Hu Y, Ren G, Zang T, Xu X, Qu J.
hem Biol Interact. 2016 Mar 5;247:30-8. doi: 10.1016/j.cbi.2016.01.013. Epub 2016 Jan 27.
 
Bioconversion of ginsenosides in the american ginseng ( xī yáng shēn) extraction residue by fermentation with lingzhi ( líng zhī, ganoderma lucidum).
Yang Hsu B, Hui Chen C, Jang Lu T, Sun Hwang L.
J Tradit Complement Med. 2013 Apr;3(2):95-101. doi: 10.4103/2225-4110.110416.
 
Structure-activity relationships of lanostane-type triterpenoids from Ganoderma lingzhi as α-glucosidase inhibitors.
Fatmawati S, Kondo R, Shimizu K.
Bioorg Med Chem Lett. 2013 Nov 1;23(21):5900-3. doi: 10.1016/j.bmcl.2013.08.084. Epub 2013 Sep 5.
 
Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors.
Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A.
Cochrane Database Syst Rev. 2015 Feb 17;2:CD007259. doi: 10.1002/14651858.CD007259.pub2.
 
Modulatory effect of crude aqueous extract of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes), on hematological and antioxidant indices in Plasmodium berghei-infected mice.
Oluba OM, Adebisi KE, Eidangbe GO, Odutuga AA, Onyeneke EC.
Int J Med Mushrooms. 2014;16(5):499-506.
 
Isolation and characterization of a hyperbranched proteoglycan from Ganoderma lucidum for anti-diabetes.
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